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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: RAB11A

Summary for RAB11A

Gene information	Gene symbol	RAB11A
	Ensembl ID	ENSG00000103769
	Entrez ID	8766
	Gene name	RAB11A, member RAS oncogene family
	Synonyms	YL8
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: RAB11A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.371163	7.97e-20
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	-0.251008	9.99e-05
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.258886	1.11e-11
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.477449	4.08e-28
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.253362	1.40e-45
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.352299	6.24e-18
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.417573	2.93e-16
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.271777	2.01e-08
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.612713	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.562884	0.00e+00

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Expression of RAB11A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RAB11A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RAB11A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RAB11A	hsa-miR-524-5p	99.4827	NM_001206836
RAB11A	hsa-miR-520d-5p	99.4827	NM_001206836
RAB11A	hsa-miR-551b-5p	97.5811	NM_001206836
RAB11A	hsa-miR-548av-5p	95.7414	NM_004663
RAB11A	hsa-miR-8054	95.7414	NM_004663
RAB11A	hsa-miR-548k	95.7414	NM_004663
RAB11A	hsa-miR-4768-3p	95.6863	NM_004663
RAB11A	hsa-miR-373-5p	95.2606	NM_001206836
RAB11A	hsa-miR-616-5p	95.2606	NM_001206836
RAB11A	hsa-miR-371b-5p	95.2606	NM_001206836
RAB11A	hsa-miR-532-5p	94.8075	NM_001206836
RAB11A	hsa-miR-153-5p	93.9164	NM_001206836
RAB11A	hsa-miR-198	93.7243	NM_001206836
RAB11A	hsa-miR-450b-5p	93.4253	NM_004663
RAB11A	hsa-miR-4802-3p	93.3518	NM_001206836
RAB11A	hsa-miR-340-5p	91.5753	NM_001206836
RAB11A	hsa-miR-17-3p	91.3144	NM_001206836
RAB11A	hsa-miR-3148	91.1451	NM_004663
RAB11A	hsa-miR-4263	90.4457	NM_004663
RAB11A	hsa-miR-3910	89.2859	NM_004663
RAB11A	hsa-miR-302e	88.9744	NM_001206836
RAB11A	hsa-miR-520a-3p	87.9384	NM_001206836
RAB11A	hsa-miR-4526	87.8238	NM_001206836
RAB11A	hsa-miR-3660	87.8238	NM_001206836
RAB11A	hsa-miR-4287	87.395	NM_004663
RAB11A	hsa-miR-4685-3p	87.395	NM_004663
RAB11A	hsa-miR-4703-5p	87.238	NM_001206836
RAB11A	hsa-miR-1279	86.5402	NM_004663
RAB11A	hsa-miR-520b-3p	86.395	NM_001206836
RAB11A	hsa-miR-520e-3p	86.395	NM_001206836
RAB11A	hsa-miR-520d-3p	86.395	NM_001206836
RAB11A	hsa-miR-372-3p	86.395	NM_001206836
RAB11A	hsa-miR-373-3p	86.395	NM_001206836
RAB11A	hsa-miR-520c-3p	86.395	NM_001206836
RAB11A	hsa-miR-4424	86.1819	NM_004663
RAB11A	hsa-miR-2467-5p	86.113	NM_004663
RAB11A	hsa-miR-520f-3p	85.8461	NM_001206836
RAB11A	hsa-miR-3942-5p	85.7743	NM_001206836
RAB11A	hsa-miR-1250-3p	85.6214	NM_001206836
RAB11A	hsa-miR-4760-3p	85.5987	NM_004663
RAB11A	hsa-miR-302d-3p	85.4773	NM_001206836
RAB11A	hsa-miR-302c-3p	85.4773	NM_001206836
RAB11A	hsa-miR-302b-3p	85.4773	NM_001206836
RAB11A	hsa-miR-302a-3p	85.4773	NM_001206836
RAB11A	hsa-miR-5579-5p	85.4011	NM_004663
RAB11A	hsa-miR-10397-3p	85.2334	NM_004663
RAB11A	hsa-miR-95-5p	85.0759	NM_001206836
RAB11A	hsa-miR-3163	84.4377	NM_001206836
RAB11A	hsa-miR-4709-3p	84.2408	NM_004663
RAB11A	hsa-miR-6501-3p	84.177	NM_004663

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Motifs and transcription factors (TFs) regulating RAB11A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RAB11A	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
RAB11A	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
RAB11A	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
RAB11A	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
RAB11A	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
RAB11A	swissregulon__hs__ELF2	ELF2 (directAnnotation).
RAB11A	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
RAB11A	hdpi__ETV4	ETV4 (directAnnotation).
RAB11A	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
RAB11A	taipale_tf_pairs__ELK1_TEF_NSCGGAWNTTACGTAAN_CAP	ELK1; TEF (directAnnotation).
RAB11A	cisbp__M02645	ETS1 (directAnnotation).
RAB11A	taipale_tf_pairs__ETV2_HOXA2_NCCGGAAGTMATTA_CAP_repr	ETV2; HOXA2 (directAnnotation).
RAB11A	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
RAB11A	taipale_tf_pairs__ETV5_EOMES_TNRCACCGGAWN_CAP	EOMES; ETV5 (directAnnotation).
RAB11A	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
RAB11A	taipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAP	ELK3; HOXB2 (directAnnotation).
RAB11A	taipale_tf_pairs__ELK1_HOXA3_RSCGGTAATKR_CAP_repr	ELK1; HOXA3 (directAnnotation).
RAB11A	jaspar__MA1483.2	ELF2 (directAnnotation).
RAB11A	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
RAB11A	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
RAB11A	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
RAB11A	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
RAB11A	taipale_tf_pairs__HOXB2_ELF1_SMGGAAGTMRTTA_CAP	ELF1; HOXB2 (directAnnotation).
RAB11A	cisbp__M08198	ELF1 (directAnnotation).
RAB11A	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
RAB11A	hdpi__TP73	TP73 (directAnnotation).
RAB11A	taipale_tf_pairs__ERF_HES7_NCCGGAANNNNNNCACGYGNN_CAP_repr	ERF; HES7 (directAnnotation).
RAB11A	hdpi__FLI1	FLI1 (directAnnotation).
RAB11A	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
RAB11A	jaspar__MA1957.1	ELK1 (directAnnotation).
RAB11A	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
RAB11A	taipale_tf_pairs__TEAD4_ETV4_RCCGGAAATRCC_CAP	ETV4; TEAD4 (directAnnotation).
RAB11A	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
RAB11A	transfac_pro__M04826	EP300 (directAnnotation).
RAB11A	taipale_tf_pairs__TEAD4_ETV1_RSCGGAAATRCM_CAP	ETV1; TEAD4 (directAnnotation).
RAB11A	taipale_tf_pairs__ETV5_EVX1_RSCGGWAATKR_CAP	ETV5; EVX1 (directAnnotation).
RAB11A	jaspar__MA1708.1	ETV7 (directAnnotation).
RAB11A	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP	ERG; TEAD4 (directAnnotation).
RAB11A	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP_repr	ERG; TEAD4 (directAnnotation).
RAB11A	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
RAB11A	taipale_tf_pairs__FLI1_FOXI1_RCCGGATGTTKWY_CAP	FLI1; FOXI1 (directAnnotation).
RAB11A	taipale_tf_pairs__ERF_FOXI1_TGTTKMCGGAWRN_CAP_repr	ERF; FOXI1 (directAnnotation).
RAB11A	metacluster_135.11	NR2C2 (directAnnotation).
RAB11A	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
RAB11A	metacluster_160.20	JUND; PRDM15 (directAnnotation).
RAB11A	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
RAB11A	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
RAB11A	cisbp__M00788	ZFY (inferredBy_Orthology).
RAB11A	hdpi__ZNF304	ZNF304 (directAnnotation).
RAB11A	transfac_pro__M02844	BCL6B (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
RAB11A	"5'-Guanosine-Diphosphate-Monothiophosphate"	DB01864	small molecule
RAB11A	"Guanosine-5'-Diphosphate"	DB04315	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."