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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PPP4R3A

Summary for PPP4R3A

Gene information	Gene symbol	PPP4R3A
	Ensembl ID	ENSG00000100796
	Entrez ID	55671
	Gene name	protein phosphatase 4 regulatory subunit 3A
	Synonyms	FLFL1\|FLJ20707\|KIAA2010\|MSTP033\|PP4R3\|SMEK1\|smk-1\|smk1
	Gene type	protein_coding
	UniProtAcc	Q6IN85

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Dataset with differentially expressed gene: PPP4R3A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.266866	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.309246	5.82e-11
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.26557	1.96e-09
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.408988	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.417159	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.346932	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.301787	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.526206	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.259046	6.48e-07

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Expression of PPP4R3A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PPP4R3A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PPP4R3A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PPP4R3A	hsa-miR-4319	99.0159	NM_001284280
PPP4R3A	hsa-miR-125b-5p	98.8242	NM_001284280
PPP4R3A	hsa-miR-125a-5p	98.8242	NM_001284280
PPP4R3A	hsa-miR-3613-3p	97.9649	NM_001284281
PPP4R3A	hsa-miR-345-3p	97.9261	NM_001284280
PPP4R3A	hsa-miR-6825-5p	97.7031	NM_001284281
PPP4R3A	hsa-miR-3140-3p	97.326	NM_001284281
PPP4R3A	hsa-miR-670-5p	96.8441	NM_001284280
PPP4R3A	hsa-miR-1271-5p	95.7048	NM_001284280
PPP4R3A	hsa-miR-96-5p	95.7048	NM_001284280
PPP4R3A	hsa-miR-12133	95.7048	NM_001284280
PPP4R3A	hsa-miR-4732-3p	95.3044	NM_001284280
PPP4R3A	hsa-miR-3163	94.3368	NM_001284280
PPP4R3A	hsa-miR-7-2-3p	93.7861	NM_001284280
PPP4R3A	hsa-miR-7-1-3p	93.7861	NM_001284280
PPP4R3A	hsa-miR-10522-5p	93.631	NM_001284280
PPP4R3A	hsa-miR-548aj-3p	93.3969	NM_001284280
PPP4R3A	hsa-miR-548x-3p	93.3969	NM_001284280
PPP4R3A	hsa-miR-17-3p	93.0876	NM_001284280
PPP4R3A	hsa-miR-6887-3p	92.9041	NM_001284280
PPP4R3A	hsa-miR-8075	92.4075	NM_001284281
PPP4R3A	hsa-miR-6864-5p	92.1765	NM_001284280
PPP4R3A	hsa-miR-6826-3p	92.0658	NM_001284280
PPP4R3A	hsa-miR-3149	91.7379	NM_001284281
PPP4R3A	hsa-miR-513b-5p	91.1252	NM_001284280
PPP4R3A	hsa-miR-6822-5p	91.0488	NM_001284281
PPP4R3A	hsa-miR-6750-5p	91.0488	NM_001284281
PPP4R3A	hsa-miR-675-3p	90.8162	NM_001284281
PPP4R3A	hsa-miR-3179	90.5586	NM_001284280
PPP4R3A	hsa-miR-7515	90.5586	NM_001284280
PPP4R3A	hsa-miR-548aq-3p	90.5427	NM_001284280
PPP4R3A	hsa-miR-548ae-3p	90.5427	NM_001284280
PPP4R3A	hsa-miR-548j-3p	90.5427	NM_001284280
PPP4R3A	hsa-miR-548am-3p	90.5427	NM_001284280
PPP4R3A	hsa-miR-548ah-3p	90.5427	NM_001284280
PPP4R3A	hsa-miR-6734-3p	90.5352	NM_001284281
PPP4R3A	hsa-miR-551b-5p	90.1193	NM_001284280
PPP4R3A	hsa-miR-95-5p	89.8958	NM_001284280
PPP4R3A	hsa-miR-4286	89.811	NM_001284281
PPP4R3A	hsa-miR-425-5p	89.6221	NM_001284281
PPP4R3A	hsa-miR-298	88.9637	NM_001284280
PPP4R3A	hsa-miR-10394-5p	88.9611	NM_001284280
PPP4R3A	hsa-miR-1205	88.9611	NM_001284280
PPP4R3A	hsa-miR-6505-5p	88.4172	NM_001284280
PPP4R3A	hsa-miR-138-2-3p	87.0663	NM_001284280
PPP4R3A	hsa-miR-4468	86.9953	NM_001284281
PPP4R3A	hsa-miR-371a-5p	86.8493	NM_001284281
PPP4R3A	hsa-miR-590-3p	86.592	NM_001284281
PPP4R3A	hsa-miR-548c-3p	86.3561	NM_001284280
PPP4R3A	hsa-miR-5697	86.2885	NM_001284281

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Motifs and transcription factors (TFs) regulating PPP4R3A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PPP4R3A	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
PPP4R3A	transfac_pro__M04916	TAF1 (directAnnotation).
PPP4R3A	metacluster_135.11	NR2C2 (directAnnotation).
PPP4R3A	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
PPP4R3A	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
PPP4R3A	cisbp__M00968	MTF2 (directAnnotation).
PPP4R3A	metacluster_198.3	ZFP64 (directAnnotation).
PPP4R3A	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
PPP4R3A	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
PPP4R3A	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
PPP4R3A	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
PPP4R3A	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
PPP4R3A	metacluster_175.1	ZNF283 (directAnnotation).
PPP4R3A	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
PPP4R3A	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
PPP4R3A	transfac_pro__M01199	TRIM28 (directAnnotation).
PPP4R3A	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
PPP4R3A	metacluster_151.2	ZNF23 (directAnnotation).
PPP4R3A	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
PPP4R3A	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
PPP4R3A	transfac_pro__M03806	ZBTB7C (directAnnotation).
PPP4R3A	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
PPP4R3A	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
PPP4R3A	jaspar__MA0748.2	YY2 (directAnnotation).
PPP4R3A	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
PPP4R3A	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
PPP4R3A	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
PPP4R3A	transfac_pro__M00430	E2F1 (directAnnotation).
PPP4R3A	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
PPP4R3A	transfac_pro__M04893	TAF1 (directAnnotation).
PPP4R3A	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
PPP4R3A	transfac_pro__M02865	GMEB1 (inferredBy_Orthology).
PPP4R3A	transfac_pro__M08894	OVOL1; OVOL2 (directAnnotation).
PPP4R3A	hdpi__HIP2	UBE2K (directAnnotation).
PPP4R3A	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
PPP4R3A	transfac_pro__M01238	DEAF1 (inferredBy_Orthology).
PPP4R3A	taipale_cyt_meth__ZBTB37_NYACCGCRNNYACCGYR_eDBD_meth_repr	ZBTB37 (directAnnotation).
PPP4R3A	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
PPP4R3A	hdpi__RARA	RARA (directAnnotation).
PPP4R3A	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
PPP4R3A	taipale_tf_pairs__TFAP2C_DLX3_NSCCNNNRGGCANNNNNNTAATKR_CAP_repr	DLX3; TFAP2C (directAnnotation).
PPP4R3A	jaspar__MA1583.1	ZFP57 (directAnnotation).
PPP4R3A	transfac_pro__M02898	SMAD3 (directAnnotation).
PPP4R3A	jaspar__MA1721.1	ZNF93 (directAnnotation).
PPP4R3A	jaspar__MA1122.1	TFDP1 (directAnnotation).
PPP4R3A	transfac_pro__M07310	SP5 (directAnnotation).
PPP4R3A	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
PPP4R3A	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
PPP4R3A	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
PPP4R3A	cisbp__M00249	WT1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."