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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PPP1R12A

Summary for PPP1R12A

Gene information	Gene symbol	PPP1R12A
	Ensembl ID	ENSG00000058272
	Entrez ID	4659
	Gene name	protein phosphatase 1 regulatory subunit 12A
	Synonyms	M130\|MBS\|MYPT1
	Gene type	protein_coding
	UniProtAcc	O14974

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Dataset with differentially expressed gene: PPP1R12A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.300423	3.88e-10
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.315184	0.00e+00
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	post	NK cells	-0.261219	3.85e-30
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Erythrocytes	0.291392	2.50e-08
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.479802	3.92e-31
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.287141	0.00e+00

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Expression of PPP1R12A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PPP1R12A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PPP1R12A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PPP1R12A	hsa-miR-19a-3p	97.916	NM_001143885
PPP1R12A	hsa-miR-19b-3p	97.916	NM_001143885
PPP1R12A	hsa-miR-3662	96.8212	NM_001244992
PPP1R12A	hsa-miR-4495	96.464	NM_001143885
PPP1R12A	hsa-miR-455-5p	96.3855	NM_001143885
PPP1R12A	hsa-miR-1179	96.3151	NM_001143885
PPP1R12A	hsa-miR-4264	95.8531	NM_001244992
PPP1R12A	hsa-miR-5002-3p	95.7462	NM_001143885
PPP1R12A	hsa-miR-4422	95.5818	NM_001143885
PPP1R12A	hsa-miR-23a-3p	94.976	NM_001143885
PPP1R12A	hsa-miR-23c	94.976	NM_001143885
PPP1R12A	hsa-miR-23b-3p	94.976	NM_001143885
PPP1R12A	hsa-let-7c-3p	94.8897	NM_001143885
PPP1R12A	hsa-miR-494-3p	93.126	NM_001143885
PPP1R12A	hsa-miR-4328	92.9446	NM_001244992
PPP1R12A	hsa-miR-1537-5p	92.5629	NM_001143885
PPP1R12A	hsa-miR-302c-5p	91.6612	NM_001143885
PPP1R12A	hsa-miR-7150	90.7509	NM_001143885
PPP1R12A	hsa-miR-95-5p	90.7245	NM_001143885
PPP1R12A	hsa-miR-9983-3p	90.6855	NM_001143885
PPP1R12A	hsa-miR-891a-3p	90.5959	NM_001143885
PPP1R12A	hsa-miR-92a-3p	90.4181	NM_001244992
PPP1R12A	hsa-miR-32-5p	90.4181	NM_001244992
PPP1R12A	hsa-miR-92b-3p	90.4181	NM_001244992
PPP1R12A	hsa-miR-30e-5p	90.2203	NM_001143885
PPP1R12A	hsa-miR-30a-5p	90.2203	NM_001143885
PPP1R12A	hsa-miR-30d-5p	90.2203	NM_001143885
PPP1R12A	hsa-miR-30c-5p	90.2203	NM_001143885
PPP1R12A	hsa-miR-30b-5p	90.2203	NM_001143885
PPP1R12A	hsa-miR-4719	89.8444	NM_001143885
PPP1R12A	hsa-miR-9902	89.8313	NM_001143885
PPP1R12A	hsa-miR-3922-3p	89.617	NM_001143885
PPP1R12A	hsa-miR-448	89.3342	NM_001143885
PPP1R12A	hsa-miR-4666a-3p	88.9536	NM_001143885
PPP1R12A	hsa-miR-129-5p	88.6038	NM_001143885
PPP1R12A	hsa-miR-4717-3p	88.1578	NM_001143885
PPP1R12A	hsa-miR-367-3p	87.9087	NM_001244992
PPP1R12A	hsa-miR-25-3p	87.9087	NM_001244992
PPP1R12A	hsa-miR-363-3p	87.9087	NM_001244992
PPP1R12A	hsa-miR-589-3p	87.7826	NM_001244992
PPP1R12A	hsa-miR-3166	87.7576	NM_001143885
PPP1R12A	hsa-miR-153-3p	87.4567	NM_001143885
PPP1R12A	hsa-miR-3176	86.4325	NM_001143885
PPP1R12A	hsa-miR-3126-3p	85.864	NM_001244992
PPP1R12A	hsa-miR-12123	85.6469	NM_001244992
PPP1R12A	hsa-miR-548ap-3p	85.4956	NM_001143885
PPP1R12A	hsa-miR-548aa	85.4956	NM_001143885
PPP1R12A	hsa-miR-548t-3p	85.4956	NM_001143885
PPP1R12A	hsa-miR-4649-3p	84.5218	NM_001244992
PPP1R12A	hsa-miR-3182	84.3818	NM_001244992

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Motifs and transcription factors (TFs) regulating PPP1R12A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PPP1R12A	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
PPP1R12A	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
PPP1R12A	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
PPP1R12A	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
PPP1R12A	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
PPP1R12A	metacluster_3.14	WT1; WT1 (directAnnotation).
PPP1R12A	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
PPP1R12A	cisbp__M07938	E2F1 (directAnnotation).
PPP1R12A	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
PPP1R12A	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
PPP1R12A	transfac_pro__M07397	ZNF148 (directAnnotation).
PPP1R12A	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
PPP1R12A	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
PPP1R12A	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
PPP1R12A	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
PPP1R12A	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
PPP1R12A	metacluster_7.13	ZFX (directAnnotation).
PPP1R12A	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
PPP1R12A	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
PPP1R12A	transfac_pro__M01175	ZBTB7B (directAnnotation).
PPP1R12A	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
PPP1R12A	tfdimers__MD00151	CHURC1 (directAnnotation).
PPP1R12A	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
PPP1R12A	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
PPP1R12A	transfac_pro__M01303	SP1 (directAnnotation).
PPP1R12A	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
PPP1R12A	swissregulon__hs__CHD1	CHD1 (directAnnotation).
PPP1R12A	transfac_pro__M02090	E2F4 (directAnnotation).
PPP1R12A	transfac_pro__M01714	KLF15 (directAnnotation).
PPP1R12A	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
PPP1R12A	jaspar__MA1122.1	TFDP1 (directAnnotation).
PPP1R12A	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
PPP1R12A	transfac_pro__M02089	E2F3 (directAnnotation).
PPP1R12A	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
PPP1R12A	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
PPP1R12A	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
PPP1R12A	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
PPP1R12A	transfac_pro__M07436	WT1 (directAnnotation).
PPP1R12A	transfac_pro__M02281	SP1 (directAnnotation).
PPP1R12A	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
PPP1R12A	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
PPP1R12A	transfac_pro__M02898	SMAD3 (directAnnotation).
PPP1R12A	transfac_public__M00491	PATZ1 (directAnnotation).
PPP1R12A	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
PPP1R12A	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
PPP1R12A	metacluster_135.11	NR2C2 (directAnnotation).
PPP1R12A	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
PPP1R12A	tfdimers__MD00038	TFAP2C (directAnnotation).
PPP1R12A	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
PPP1R12A	cisbp__M00968	MTF2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."