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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: PLK2

Summary for PLK2

Gene information	Gene symbol	PLK2
	Ensembl ID	ENSG00000145632
	Entrez ID	10769
	Gene name	polo like kinase 2
	Synonyms	SNK
	Gene type	protein_coding
	UniProtAcc	Q9NYY3

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Dataset with differentially expressed gene: PLK2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.666675	0.00e+00
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	0.26012	1.52e-17
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-1.05388	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.394476	1.33e-19
GSE104987	MCF7 cell line	Cell line	Breast cancer	ER+ breast cancer	Targeted therapy	KDM5-C70	NA	Malignant cells	-0.496933	1.92e-29
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-1.1623	0.00e+00
GSE164897_Vem	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib	NA	Malignant cells	0.409111	0.00e+00

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Expression of PLK2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PLK2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PLK2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PLK2	hsa-miR-9985	99.6963	NM_001252226
PLK2	hsa-miR-27a-3p	99.6963	NM_001252226
PLK2	hsa-miR-27b-3p	99.6963	NM_001252226
PLK2	hsa-miR-216a-3p	97.9928	NM_001252226
PLK2	hsa-miR-128-3p	97.9928	NM_001252226
PLK2	hsa-miR-3681-3p	96.5281	NM_001252226
PLK2	hsa-miR-6512-3p	95.4593	NM_006622
PLK2	hsa-miR-6720-5p	95.4593	NM_006622
PLK2	hsa-miR-1537-5p	93.9405	NM_001252226
PLK2	hsa-miR-12136	93.3911	NM_006622
PLK2	hsa-miR-513a-5p	90.747	NM_001252226
PLK2	hsa-miR-676-5p	90.6197	NM_006622
PLK2	hsa-miR-561-3p	89.4663	NM_006622
PLK2	hsa-miR-3187-3p	88.624	NM_001252226
PLK2	hsa-miR-6124	87.9246	NM_001252226
PLK2	hsa-miR-5000-5p	87.7472	NM_001252226
PLK2	hsa-miR-4675	87.487	NM_006622
PLK2	hsa-miR-4741	87.487	NM_006622
PLK2	hsa-miR-584-3p	86.5259	NM_001252226
PLK2	hsa-miR-342-3p	85.4217	NM_001252226
PLK2	hsa-miR-2054	85.3999	NM_001252226
PLK2	hsa-miR-6756-3p	84.9588	NM_006622
PLK2	hsa-miR-3127-3p	84.9588	NM_006622
PLK2	hsa-miR-137-3p	83.1495	NM_001252226
PLK2	hsa-miR-544a	82.7359	NM_006622
PLK2	hsa-miR-1587	82.2482	NM_006622
PLK2	hsa-miR-3620-5p	80.5862	NM_006622
PLK2	hsa-miR-6830-5p	80.3678	NM_001252226

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Motifs and transcription factors (TFs) regulating PLK2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PLK2	metacluster_111.6	GMEB1; GMEB2 (directAnnotation).
PLK2	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
PLK2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
PLK2	transfac_pro__M07397	ZNF148 (directAnnotation).
PLK2	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
PLK2	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
PLK2	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
PLK2	metacluster_7.13	ZFX (directAnnotation).
PLK2	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
PLK2	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
PLK2	transfac_pro__M01175	ZBTB7B (directAnnotation).
PLK2	tfdimers__MD00151	CHURC1 (directAnnotation).
PLK2	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
PLK2	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
PLK2	transfac_pro__M01303	SP1 (directAnnotation).
PLK2	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
PLK2	transfac_pro__M02090	E2F4 (directAnnotation).
PLK2	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
PLK2	jaspar__MA1122.1	TFDP1 (directAnnotation).
PLK2	transfac_pro__M02089	E2F3 (directAnnotation).
PLK2	metacluster_3.14	WT1; WT1 (directAnnotation).
PLK2	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
PLK2	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
PLK2	cisbp__M07938	E2F1 (directAnnotation).
PLK2	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
PLK2	transfac_pro__M07436	WT1 (directAnnotation).
PLK2	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
PLK2	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
PLK2	transfac_pro__M02898	SMAD3 (directAnnotation).
PLK2	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
PLK2	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
PLK2	taipale_tf_pairs__ETV2_HES7_NNCACGTGNNNNNCGGAWRY_CAP_repr	ETV2; HES7 (directAnnotation).
PLK2	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
PLK2	cisbp__M08198	ELF1 (directAnnotation).
PLK2	transfac_pro__M04866	HDAC2 (directAnnotation).
PLK2	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
PLK2	transfac_pro__M08819	KLF2 (directAnnotation).
PLK2	swissregulon__hs__KLF6	KLF6 (directAnnotation).
PLK2	transfac_pro__M00716	ZBTB14 (directAnnotation).
PLK2	metacluster_133.2	CPSF4; CPSF4; E2F4; FOXO3; KLF13; KLF15; KLF17; KLF5; MAZ; MAZ; MAZ; MZF1; PATZ1; PATZ1; PATZ1; PATZ1; PLAG1; PRDM9; SP4; VEZF1; WT1; ZBTB17; ZBTB7A; ZBTB7A; ZBTB7B; ZNF148; ZNF148; ZNF148; ZNF148; ZNF180; ZNF180; ZNF202; ZNF219; ZNF219; ZNF263; ZNF263; ZNF28; ZNF281; ZNF281; ZNF281; ZNF281; ZNF281; ZNF383; ZNF398; ZNF398; ZNF444; ZNF444; ZNF467; ZNF543; ZNF543; ZNF641; ZNF692; ZNF737; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF880; ZNF880 (directAnnotation). MAZ; PLAG1; PLAGL1; SP1; SP5; SP5; ZBTB17; ZNF281; ZNF281; ZNF281; ZNF641; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
PLK2	transfac_pro__M00986	CHURC1 (directAnnotation).
PLK2	metacluster_135.11	NR2C2 (directAnnotation).
PLK2	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
PLK2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
PLK2	cisbp__M00968	MTF2 (directAnnotation).
PLK2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
PLK2	cisbp__M00341	PAX6 (directAnnotation).
PLK2	metacluster_198.3	ZFP64 (directAnnotation).
PLK2	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
PLK2	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
PLK2	"Fostamatinib"	DB12010	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."