Dataset | Source | Tissue | Cancer type level1 | Cancer type level2 | Drug type | Regimen | Timepoint | Cell type | avg_log2FC | p_val_adj |
GSE131984_Pac | SUM159 cell line | Cell line | Breast cancer | Triple-negative breast cancer (TNBC) | Chemotherapy | paclitaxel | NA | Malignant cells | -0.722042 | 1.99e-18 |
GSE169246_PacTissue | patients | Tumor tissue | Breast cancer | Advanced triple-negative breast cancer (TNBC) | Chemotherapy | paclitaxel | pre | cDCs | 0.839535 | 5.44e-04 |
GSE197268_Axi-cel | patients | Peripheral blood mononuclear cells | Acute lymphoblastic leukemia | Large B-cell acute lymphoblastic leukemia (B-ALL) | Immunotherapy | axi-cel (CAR-T) | post | cDCs | -0.389083 | 1.10e-02 |
GSE158457 | PDX cells | Cell line | Acute lymphoblastic leukemia | T-cell acute lymphoblastic leukemia (ALL) | Targeted therapy | dasatinib | NA | Malignant cells | -0.399355 | 0.00e+00 |
GSE162117 | patients | Peripheral blood mononuclear cells | Acute myeloid leukemia | Tefractory acute myeloid leukemia (AML) | Targeted therapy | ficlatuzumab | post | cDCs | 0.294745 | 4.88e-10 |
GSE131984_JQ1 | SUM159 cell line | Cell line | Breast cancer | Triple-negative breast cancer (TNBC) | Targeted therapy | JQ1 | NA | Malignant cells | -0.732269 | 3.63e-33 |
GSE131984_JQ1Pac | SUM159 cell line | Cell line | Breast cancer | Triple-negative breast cancer (TNBC) | Targeted therapy | JQ1 + paclitaxel | NA | Malignant cells | -0.819958 | 9.81e-27 |
GSE131984_JQ1Pal | SUM159 cell line | Cell line | Breast cancer | Triple-negative breast cancer (TNBC) | Targeted therapy | JQ1 + palbociclib | NA | Malignant cells | -0.972465 | 0.00e+00 |
GSE175716 | PDX | Tumor tissue | Liver cancer | Advanced hepatocellular carcinoma | Targeted therapy | sorafenib | NA | Malignant cells | 0.545475 | 0.00e+00 |
GSE115251 | Kelly cell line | Cell line | Neuroblastoma | Neuroblastoma | Targeted therapy | TAE684 | NA | Malignant cells | 2.60092 | 0.00e+00 |
Gene symbol | motif | TF_highConf |
PKIB | taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr | E2F1; HES7 (directAnnotation). |
PKIB | kznf__ZNF25_Imbeault2017_OM_MEME | ZNF25 (directAnnotation). |
PKIB | taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP | ETV5; HES7 (directAnnotation). |
PKIB | kznf__ZFP57_Imbeault2017_RP_ChIP-seq | ZFP57 (directAnnotation). |
PKIB | metacluster_195.2 | EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology). |
PKIB | metacluster_67.2 | ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology). |
PKIB | metacluster_3.14 | WT1; WT1 (directAnnotation). |
PKIB | swissregulon__hs__ZBTB14 | ZBTB14 (directAnnotation). |
PKIB | cisbp__M07938 | E2F1 (directAnnotation). |
PKIB | metacluster_55.3 | E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology). |
PKIB | taipale_tf_pairs__GCM1_SPDEF_RTRSKGGCGGANNNNNNATCCNNN_CAP_repr | GCM1; SPDEF (directAnnotation). |
PKIB | transfac_pro__M00652 | NRF1 (directAnnotation). |
PKIB | metacluster_2.7 | IRF1; IRF1; IRF2; IRF2; IRF3; IRF4; IRF5; IRF6; IRF7; IRF7; IRF8; IRF8; IRF9; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; STAT1; STAT1; STAT2 (directAnnotation). PRDM1; PRDM1; PRDM1 (inferredBy_Orthology). |
PKIB | transfac_pro__M05629 | ZNF44 (directAnnotation). |
PKIB | tfdimers__MD00007 | E2F1; IRF8 (directAnnotation). |
PKIB | metacluster_161.51 | PDX1 (directAnnotation). |
PKIB | metacluster_160.15 | ATF5; ATF5 (directAnnotation). |
PKIB | transfac_pro__M05815 | ZNF613 (directAnnotation). |
PKIB | taipale__CUX1_DBD_ATCRATNNNNNATCRAT_repr | CUX1 (directAnnotation). |
PKIB | taipale_tf_pairs__TEAD4_HOXA2_RCATTCNNNNNNCATTA_CAP | HOXA2; TEAD4 (directAnnotation). |
PKIB | taipale_tf_pairs__TEAD4_HOXA3_RCATTCNNNNNNCATTA_CAP | HOXA3; TEAD4 (directAnnotation). |
PKIB | transfac_pro__M06799 | ZSCAN12 (directAnnotation). |
PKIB | metacluster_161.71 | HOXD3 (directAnnotation). |
PKIB | metacluster_161.50 | HOXA2 (directAnnotation). |
PKIB | taipale_cyt_meth__TLX3_NAATTGNNNNNNNNNNCAATTN_FL_repr | TLX3 (directAnnotation). |
PKIB | transfac_pro__M05520 | E4F1 (inferredBy_Orthology). |
PKIB | metacluster_138.2 | ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology). |
PKIB | swissregulon__hs__ELF2 | ELF2 (directAnnotation). |
PKIB | hdpi__TP73 | TP73 (directAnnotation). |
PKIB | swissregulon__mm__E2f7 | E2F7 (inferredBy_Orthology). |
PKIB | hdpi__ELF2 | ELF2 (directAnnotation). |
PKIB | metacluster_183.4 | ETS1 (inferredBy_Orthology). |
PKIB | metacluster_34.3 | EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation). |
PKIB | taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr | E2F1; ELK1 (directAnnotation). |
PKIB | transfac_pro__M04862 | NRF1 (directAnnotation). |
PKIB | taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth | ZNF385D (directAnnotation). |
PKIB | jaspar__MA1933.1 | SREBF2 (directAnnotation). |
PKIB | metacluster_81.7 | CREB1 (directAnnotation). |
PKIB | taipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAP | ELK3; HOXB2 (directAnnotation). |
PKIB | hdpi__FLI1 | FLI1 (directAnnotation). |
PKIB | taipale_tf_pairs__ERF_FOXI1_TGTTKMCGGAWRN_CAP_repr | ERF; FOXI1 (directAnnotation). |
PKIB | transfac_pro__M00492 | STAT1 (directAnnotation). |
PKIB | metacluster_174.3 | MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation). |
PKIB | transfac_pro__M06063 | ZNF99 (directAnnotation). |
PKIB | cisbp__M01725 | SREBF2 (inferredBy_Orthology). |
PKIB | jaspar__MA1562.1 | SOX14 (directAnnotation). |
PKIB | metacluster_14.23 | TFE3 (directAnnotation). |
PKIB | transfac_pro__M06084 | ZNF208 (directAnnotation). |
PKIB | metacluster_102.2 | ZBED1 (directAnnotation). |
PKIB | transfac_pro__M05474 | ZNF639 (directAnnotation). |
1 | "Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618." |
2 | "Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335." |