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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NUCKS1

Summary for NUCKS1

Gene information	Gene symbol	NUCKS1
	Ensembl ID	ENSG00000069275
	Entrez ID	64710
	Gene name	nuclear casein kinase and cyclin dependent kinase substrate 1
	Synonyms	NUCKS
	Gene type	protein_coding
	UniProtAcc	Q9H1E3

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Dataset with differentially expressed gene: NUCKS1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.897944	0.00e+00
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.632991	0.00e+00
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.371378	0.00e+00
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.418014	1.07e-19
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	B cells	-0.468674	2.04e-21
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Erythrocytes	-0.445641	3.10e-21
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	CD4+ T cells	0.254035	3.52e-02
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.732891	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-1.23764	0.00e+00
GSE158457	PDX cells	Cell line	Acute lymphoblastic leukemia	T-cell acute lymphoblastic leukemia (ALL)	Targeted therapy	dasatinib	NA	Malignant cells	-0.309742	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.63335	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.338234	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Erythrocytes	0.325635	3.05e-07
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.290227	0.00e+00
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	post	CD8+ T cells	-0.293289	5.26e-15
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.429063	7.18e-32
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Malignant cells	-0.356808	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	-0.395242	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	1.30972	0.00e+00

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Expression of NUCKS1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NUCKS1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
NUCKS1	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating NUCKS1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NUCKS1	hsa-miR-548e-5p	98.093	NM_022731
NUCKS1	hsa-miR-4311	97.7728	NM_022731
NUCKS1	hsa-miR-4775	96.2764	NM_022731
NUCKS1	hsa-miR-3065-5p	95.8498	NM_022731
NUCKS1	hsa-miR-374c-5p	95.4438	NM_022731
NUCKS1	hsa-miR-655-3p	95.4438	NM_022731
NUCKS1	hsa-miR-7159-5p	95.0329	NM_022731
NUCKS1	hsa-miR-4762-5p	94.3446	NM_022731
NUCKS1	hsa-miR-6165	93.8806	NM_022731
NUCKS1	hsa-miR-3119	92.2444	NM_022731
NUCKS1	hsa-miR-7848-3p	91.9375	NM_022731
NUCKS1	hsa-miR-140-5p	90.3952	NM_022731
NUCKS1	hsa-miR-6834-3p	90.3175	NM_022731
NUCKS1	hsa-miR-8065	88.5358	NM_022731
NUCKS1	hsa-miR-561-3p	88.5023	NM_022731
NUCKS1	hsa-miR-137-3p	88.098	NM_022731
NUCKS1	hsa-miR-3065-3p	87.3423	NM_022731
NUCKS1	hsa-miR-7159-3p	87.0044	NM_022731
NUCKS1	hsa-miR-1208	86.9722	NM_022731
NUCKS1	hsa-miR-30c-5p	86.7225	NM_022731
NUCKS1	hsa-miR-30a-5p	86.7225	NM_022731
NUCKS1	hsa-miR-30e-5p	86.7225	NM_022731
NUCKS1	hsa-miR-30d-5p	86.7225	NM_022731
NUCKS1	hsa-miR-30b-5p	86.7225	NM_022731
NUCKS1	hsa-miR-4495	86.623	NM_022731
NUCKS1	hsa-miR-7106-3p	86.0378	NM_022731
NUCKS1	hsa-miR-142-3p	86.0019	NM_022731
NUCKS1	hsa-miR-940	85.8519	NM_022731
NUCKS1	hsa-miR-6893-5p	85.849	NM_022731
NUCKS1	hsa-miR-6808-5p	85.849	NM_022731
NUCKS1	hsa-miR-12136	85.5717	NM_022731
NUCKS1	hsa-miR-340-5p	85.4093	NM_022731
NUCKS1	hsa-miR-3613-3p	85.2291	NM_022731
NUCKS1	hsa-miR-4796-3p	84.9817	NM_022731
NUCKS1	hsa-miR-590-3p	84.8899	NM_022731
NUCKS1	hsa-miR-5696	84.7292	NM_022731
NUCKS1	hsa-miR-141-3p	84.4206	NM_022731
NUCKS1	hsa-miR-200a-3p	84.4206	NM_022731
NUCKS1	hsa-miR-2909	84.3893	NM_022731
NUCKS1	hsa-miR-624-5p	84.2363	NM_022731
NUCKS1	hsa-miR-4799-5p	83.392	NM_022731
NUCKS1	hsa-miR-4722-5p	82.8292	NM_022731
NUCKS1	hsa-miR-302b-5p	82.451	NM_022731
NUCKS1	hsa-miR-7-2-3p	82.351	NM_022731
NUCKS1	hsa-miR-7-1-3p	82.351	NM_022731
NUCKS1	hsa-miR-497-3p	81.8837	NM_022731
NUCKS1	hsa-miR-4499	81.8009	NM_022731
NUCKS1	hsa-miR-1200	81.556	NM_022731
NUCKS1	hsa-miR-4433b-5p	81.5282	NM_022731
NUCKS1	hsa-miR-5006-3p	81.4443	NM_022731

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Motifs and transcription factors (TFs) regulating NUCKS1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NUCKS1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
NUCKS1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
NUCKS1	transfac_pro__M07397	ZNF148 (directAnnotation).
NUCKS1	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
NUCKS1	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
NUCKS1	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
NUCKS1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
NUCKS1	metacluster_7.13	ZFX (directAnnotation).
NUCKS1	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
NUCKS1	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
NUCKS1	transfac_pro__M01175	ZBTB7B (directAnnotation).
NUCKS1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
NUCKS1	tfdimers__MD00151	CHURC1 (directAnnotation).
NUCKS1	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
NUCKS1	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
NUCKS1	transfac_pro__M01303	SP1 (directAnnotation).
NUCKS1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
NUCKS1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
NUCKS1	transfac_pro__M02090	E2F4 (directAnnotation).
NUCKS1	transfac_pro__M01714	KLF15 (directAnnotation).
NUCKS1	jaspar__MA1122.1	TFDP1 (directAnnotation).
NUCKS1	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
NUCKS1	transfac_pro__M02089	E2F3 (directAnnotation).
NUCKS1	transfac_pro__M12604	ZNF444 (directAnnotation).
NUCKS1	metacluster_3.14	WT1; WT1 (directAnnotation).
NUCKS1	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
NUCKS1	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
NUCKS1	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
NUCKS1	cisbp__M07938	E2F1 (directAnnotation).
NUCKS1	kznf__ZNF202_Imbeault2017_OM_MEME	ZNF202 (directAnnotation).
NUCKS1	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
NUCKS1	transfac_pro__M07436	WT1 (directAnnotation).
NUCKS1	transfac_pro__M02281	SP1 (directAnnotation).
NUCKS1	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
NUCKS1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
NUCKS1	metacluster_3.3	KLF10; KLF15; KLF16; KLF9; SP1 (directAnnotation).
NUCKS1	transfac_pro__M02898	SMAD3 (directAnnotation).
NUCKS1	transfac_public__M00491	PATZ1 (directAnnotation).
NUCKS1	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
NUCKS1	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
NUCKS1	transfac_pro__M04950	EGR1 (directAnnotation).
NUCKS1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
NUCKS1	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
NUCKS1	taipale_tf_pairs__ERF_HES7_NNCACGTGNNNNCCGGAANN_CAP_repr	ERF; HES7 (directAnnotation).
NUCKS1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
NUCKS1	transfac_pro__M00652	NRF1 (directAnnotation).
NUCKS1	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
NUCKS1	transfac_pro__M04866	HDAC2 (directAnnotation).
NUCKS1	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
NUCKS1	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."