Dataset | Source | Tissue | Cancer type level1 | Cancer type level2 | Drug type | Regimen | Timepoint | Cell type | avg_log2FC | p_val_adj |
GSE186960 | Panc1 cell line | Cell line | Pancreatic cancer | Pancreatic ductal adenocarcinoma (PDAC) | Chemotherapy | gemcitabine | NA | Malignant cells | -0.380524 | 6.14e-21 |
GSE163836 | FCIBC02 cell line | Cell line | Breast cancer | Inflammatory breast cancer | Chemotherapy | paclitaxel | NA | Malignant cells | -0.496128 | 0.00e+00 |
GSE197268_Axi-cel | patients | Peripheral blood mononuclear cells | Acute lymphoblastic leukemia | Large B-cell acute lymphoblastic leukemia (B-ALL) | Immunotherapy | axi-cel (CAR-T) | post | CD4+ T cells | 0.318457 | 7.29e-10 |
PMID34715028 | patients | Tumor tissue | Kidney cancer | Clear cell renal cell carcinoma (ccRCC) | Immunotherapy | nivolumab | post | CD4+ T cells | 0.292473 | 1.81e-13 |
GSE197268_Tisa-cel | patients | Peripheral blood mononuclear cells | Acute lymphoblastic leukemia | Large B-cell acute lymphoblastic leukemia (B-ALL) | Immunotherapy | tisa-cel (CAR-T) | pre | CD4+ T cells | 0.304797 | 4.75e-24 |
GSE197268_Tisa-cel | patients | Peripheral blood mononuclear cells | Acute lymphoblastic leukemia | Large B-cell acute lymphoblastic leukemia (B-ALL) | Immunotherapy | tisa-cel (CAR-T) | pre | CD8+ T cells | 0.350818 | 0.00e+00 |
GSE199333 | patients | Bone marrow aspirate | Acute myeloid leukemia | Primary FLT3-ITD-mutated acute myeloid leukemia (AML) | Targeted therapy | gilteritinib | post | NK cells | 0.581374 | 0.00e+00 |
GSE199333 | patients | Bone marrow aspirate | Acute myeloid leukemia | Primary FLT3-ITD-mutated acute myeloid leukemia (AML) | Targeted therapy | gilteritinib | post | Malignant cells | 0.261289 | 0.00e+00 |
GSE199333 | patients | Bone marrow aspirate | Acute myeloid leukemia | Primary FLT3-ITD-mutated acute myeloid leukemia (AML) | Targeted therapy | gilteritinib | post | CD8+ T cells | 0.452216 | 0.00e+00 |
GSE199333 | patients | Bone marrow aspirate | Acute myeloid leukemia | Primary FLT3-ITD-mutated acute myeloid leukemia (AML) | Targeted therapy | gilteritinib | post | CD4+ T cells | 0.673692 | 0.00e+00 |
GSE111014 | patients | Peripheral blood mononuclear cells | Chronic lymphocytic leukemia | Chronic lymphocytic leukemia (CLL) | Targeted therapy | ibrutinib | pre | Malignant cells | -0.278932 | 0.00e+00 |
GSE131984_JQ1Pal | SUM159 cell line | Cell line | Breast cancer | Triple-negative breast cancer (TNBC) | Targeted therapy | JQ1 + palbociclib | NA | Malignant cells | -0.318673 | 8.24e-16 |
GSE131984_Pal | SUM159 cell line | Cell line | Breast cancer | Triple-negative breast cancer (TNBC) | Targeted therapy | palbociclib | NA | Malignant cells | -0.466346 | 4.89e-24 |
GSE175716 | PDX | Tumor tissue | Liver cancer | Advanced hepatocellular carcinoma | Targeted therapy | sorafenib | NA | Malignant cells | -0.456154 | 7.01e-45 |
GSE115251 | Kelly cell line | Cell line | Neuroblastoma | Neuroblastoma | Targeted therapy | TAE684 | NA | Malignant cells | 0.265562 | 0.00e+00 |
GSE164897_VemCob | A375 cell line | Cell line | Melanoma | BRAFV600E-mutant melanoma | Targeted therapy | vemurafenib + combimetinib | NA | Malignant cells | -0.767993 | 0.00e+00 |
GSE164897_VemTra | A375 cell line | Cell line | Melanoma | B+E2:E57RAFV600E-mutant melanoma | Targeted therapy | vemurafenib + trametinib | NA | Malignant cells | -0.584207 | 0.00e+00 |
Gene symbol | motif | TF_highConf |
NOSIP | taipale_tf_pairs__ETS2_RCCGGAAGTG_HT | ETS2 (directAnnotation). |
NOSIP | metacluster_191.3 | EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology). |
NOSIP | taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP | ETV4; HOXB2 (directAnnotation). |
NOSIP | taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT | ELF2 (directAnnotation). |
NOSIP | jaspar__MA1483.2 | ELF2 (directAnnotation). |
NOSIP | metacluster_191.2 | ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology). |
NOSIP | metacluster_166.4 | BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology). |
NOSIP | transfac_pro__M04826 | EP300 (directAnnotation). |
NOSIP | taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP | ETV5; HOXA2 (directAnnotation). |
NOSIP | hdpi__FLI1 | FLI1 (directAnnotation). |
NOSIP | metacluster_166.2 | ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology). |
NOSIP | swissregulon__hs__ELF2 | ELF2 (directAnnotation). |
NOSIP | taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP | ELK3; FOXO1 (directAnnotation). |
NOSIP | taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT | ELK1; HOXA1 (directAnnotation). |
NOSIP | taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP | ETV5; FOXI1 (directAnnotation). |
NOSIP | taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP | ELK1; FOXI1 (directAnnotation). |
NOSIP | jaspar__MA1933.1 | SREBF2 (directAnnotation). |
NOSIP | taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr | ERF; FOXI1 (directAnnotation). |
NOSIP | cisbp__M02645 | ETS1 (directAnnotation). |
NOSIP | jaspar__MA1708.1 | ETV7 (directAnnotation). |
NOSIP | taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP | ETV4; FOXO1 (directAnnotation). |
NOSIP | taipale_tf_pairs__ETV5_EVX1_RSCGGWAATKR_CAP | ETV5; EVX1 (directAnnotation). |
NOSIP | metacluster_138.2 | ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology). |
NOSIP | hdpi__ETV4 | ETV4 (directAnnotation). |
NOSIP | taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP | ELK1; FOXO1 (directAnnotation). |
NOSIP | taipale_tf_pairs__HOXB2_ELK1_TAATKRCCGGAAGNN_CAP_repr | ELK1; HOXB2 (directAnnotation). |
NOSIP | taipale_tf_pairs__ELK1_HOXA3_RSCGGTAATKR_CAP_repr | ELK1; HOXA3 (directAnnotation). |
NOSIP | taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP | ETV2; FOXO6 (directAnnotation). |
NOSIP | taipale_tf_pairs__ETV2_FOXI1_RSCGGATGTTKW_CAP | ETV2; FOXI1 (directAnnotation). |
NOSIP | taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr | ELK1; EOMES (directAnnotation). |
NOSIP | taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP | ELK1; EOMES (directAnnotation). |
NOSIP | taipale_tf_pairs__HOXB2_ETV1_ACCGGAAATGA_CAP | ETV1; HOXB2 (directAnnotation). |
NOSIP | taipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAP | ELK3; HOXB2 (directAnnotation). |
NOSIP | taipale_tf_pairs__ETV2_DLX3_RSCGGAANNNNNNNTAATKR_CAP_repr | DLX3; ETV2 (directAnnotation). |
NOSIP | taipale_tf_pairs__ETV2_DRGX_RSCGGAWRYATTA_CAP_repr | DRGX; ETV2 (directAnnotation). |
NOSIP | taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr | ELK1; TBX21 (directAnnotation). |
NOSIP | taipale_tf_pairs__ELK1_FOXI1_WGTTKMCGGAWRTN_CAP | ELK1; FOXI1 (directAnnotation). |
NOSIP | taipale_tf_pairs__FOXO1_ELK1_TGTTGCCGGANNN_CAP | ELK1; FOXO1 (directAnnotation). |
NOSIP | transfac_pro__M04794 | TAF1 (directAnnotation). |
NOSIP | taipale_tf_pairs__FOXO1_ETV1_RCCGGAWGTKKN_CAP | ETV1; FOXO1 (directAnnotation). |
NOSIP | transfac_pro__M00492 | STAT1 (directAnnotation). |
NOSIP | taipale_tf_pairs__TEAD4_ETV1_RSCGGAAATRCM_CAP | ETV1; TEAD4 (directAnnotation). |
NOSIP | tfdimers__MD00421 | ELF3; POU5F1 (directAnnotation). |
NOSIP | transfac_pro__M06763 | ZNF225 (directAnnotation). |
NOSIP | swissregulon__mm__Nr4a1 | NR4A1 (inferredBy_Orthology). |
NOSIP | transfac_pro__M05941 | ZNF471 (directAnnotation). |
NOSIP | taipale_tf_pairs__ERF_HOXA3_RSCGGAWNNNNNNNYMATTA_CAP_repr | ERF; HOXA3 (directAnnotation). |
NOSIP | tfdimers__MD00066 | ELF1 (directAnnotation). |
NOSIP | transfac_pro__M07285 | ELF3 (directAnnotation). |
NOSIP | metacluster_183.3 | EHF; ELF3; FLI1; SPIB (directAnnotation). EHF; EHF; ELF2; ELF3; ELF4; ELF5; ERG; ERG; ETV3; ETV6; FLI1; SPI1; SPI1 (inferredBy_Orthology). |
1 | "Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618." |
2 | "Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335." |