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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NCOA4

Summary for NCOA4

Gene information	Gene symbol	NCOA4
	Ensembl ID	ENSG00000266412
	Entrez ID	8031
	Gene name	nuclear receptor coactivator 4
	Synonyms	ARA70\|DKFZp762E1112\|ELE1\|PTC3\|RFG
	Gene type	protein_coding
	UniProtAcc	Q13772

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Dataset with differentially expressed gene: NCOA4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.443181	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	0.348499	3.98e-06
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	-1.14435	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Erythrocytes	0.403362	2.80e-25
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	0.770123	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.285929	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.417979	1.51e-33

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Expression of NCOA4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NCOA4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NCOA4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NCOA4	hsa-miR-4672	95.2859	NM_001145260
NCOA4	hsa-miR-548x-5p	95.2538	NM_001145263
NCOA4	hsa-miR-548f-5p	95.2538	NM_001145263
NCOA4	hsa-miR-548g-5p	95.2538	NM_001145263
NCOA4	hsa-miR-548aj-5p	95.2538	NM_001145263
NCOA4	hsa-miR-513b-3p	92.8039	NM_001145263
NCOA4	hsa-miR-6768-5p	92.1322	NM_001145260
NCOA4	hsa-miR-3140-3p	90.818	NM_001145260
NCOA4	hsa-miR-5582-5p	90.7375	NM_001145260
NCOA4	hsa-miR-10522-5p	90.0803	NM_001145263
NCOA4	hsa-miR-4661-5p	88.8921	NM_001145263
NCOA4	hsa-miR-34b-3p	87.3004	NM_001145263
NCOA4	hsa-miR-8062	86.977	NM_001145263
NCOA4	hsa-miR-767-5p	86.5321	NM_001145260
NCOA4	hsa-miR-4443	86.3799	NM_001145263
NCOA4	hsa-miR-4775	85.6121	NM_001145263
NCOA4	hsa-miR-6847-3p	85.5576	NM_001145263
NCOA4	hsa-miR-4774-3p	85.2105	NM_001145260
NCOA4	hsa-miR-4291	84.7275	NM_001145263
NCOA4	hsa-miR-4516	84.6234	NM_001145260
NCOA4	hsa-miR-1277-5p	84.2693	NM_001145263
NCOA4	hsa-miR-506-3p	84.0152	NM_001145260
NCOA4	hsa-miR-124-3p	84.0152	NM_001145260
NCOA4	hsa-miR-6808-5p	84.0056	NM_001145263
NCOA4	hsa-miR-6893-5p	84.0056	NM_001145263
NCOA4	hsa-miR-940	84.0056	NM_001145263
NCOA4	hsa-miR-6787-3p	83.8061	NM_001145263
NCOA4	hsa-miR-1297	83.22	NM_001145260
NCOA4	hsa-miR-19a-3p	82.631	NM_001145263
NCOA4	hsa-miR-664b-5p	82.3354	NM_001145263
NCOA4	hsa-miR-4687-3p	81.8442	NM_001145263
NCOA4	hsa-miR-4773	81.7796	NM_001145263
NCOA4	hsa-miR-4465	81.2146	NM_001145260
NCOA4	hsa-miR-182-5p	81.1129	NM_001145260
NCOA4	hsa-miR-6835-3p	80.3336	NM_001145260
NCOA4	hsa-miR-26b-5p	80.0119	NM_001145260
NCOA4	hsa-miR-26a-5p	80.0119	NM_001145260

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Motifs and transcription factors (TFs) regulating NCOA4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NCOA4	metacluster_135.11	NR2C2 (directAnnotation).
NCOA4	tfdimers__MD00038	TFAP2C (directAnnotation).
NCOA4	metacluster_7.13	ZFX (directAnnotation).
NCOA4	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
NCOA4	cisbp__M00968	MTF2 (directAnnotation).
NCOA4	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
NCOA4	metacluster_160.20	JUND; PRDM15 (directAnnotation).
NCOA4	cisbp__M00341	PAX6 (directAnnotation).
NCOA4	metacluster_198.3	ZFP64 (directAnnotation).
NCOA4	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
NCOA4	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
NCOA4	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
NCOA4	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
NCOA4	cisbp__M00788	ZFY (inferredBy_Orthology).
NCOA4	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
NCOA4	metacluster_175.1	ZNF283 (directAnnotation).
NCOA4	hdpi__ZNF304	ZNF304 (directAnnotation).
NCOA4	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
NCOA4	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
NCOA4	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
NCOA4	transfac_pro__M01199	TRIM28 (directAnnotation).
NCOA4	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
NCOA4	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
NCOA4	transfac_pro__M03806	ZBTB7C (directAnnotation).
NCOA4	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
NCOA4	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
NCOA4	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
NCOA4	metacluster_33.8	BRCA1; CHD2; CHD2; ETS1; NR3C1; ZBED1; ZBED1; ZBED1; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33 (directAnnotation). CHD2; ZBTB33 (inferredBy_Orthology).
NCOA4	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
NCOA4	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
NCOA4	metacluster_182.10	ZFX (directAnnotation).
NCOA4	transfac_pro__M01973	PLAG1 (directAnnotation).
NCOA4	homer__ATTGCGCAAC_CEBP	CEBPB (inferredBy_Orthology).
NCOA4	transfac_pro__M05845	ZSCAN29 (directAnnotation).
NCOA4	transfac_pro__M01122	ZNF219 (directAnnotation).
NCOA4	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
NCOA4	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
NCOA4	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
NCOA4	taipale_tf_pairs__GCM1_SPDEF_RTRSKGGCGGANNNNNATCCNNN_CAP_repr	GCM1; SPDEF (directAnnotation).
NCOA4	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
NCOA4	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
NCOA4	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
NCOA4	jaspar__MA1721.1	ZNF93 (directAnnotation).
NCOA4	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
NCOA4	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
NCOA4	jaspar__MA1122.1	TFDP1 (directAnnotation).
NCOA4	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
NCOA4	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
NCOA4	metacluster_35.2	EGR1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF3; ELF4; ELF4; ELK1; ELK3; ELK4; ERG; ETS1; ETS1; ETS2; ETV1; ETV1; ETV5; ETV5; ETV6; FLI1; FLI1; GABPA; GABPA; GABPA; GABPB1; GABPB1; GABPB1; ZBTB7A (directAnnotation). ELF2; ELF2; ERG; ERG; ETS2; FLI1; GABPA; IKZF3; SPIC (inferredBy_Orthology).
NCOA4	tfdimers__MD00151	CHURC1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."