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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NCOA3

Summary for NCOA3

Gene information	Gene symbol	NCOA3
	Ensembl ID	ENSG00000124151
	Entrez ID	8202
	Gene name	nuclear receptor coactivator 3
	Synonyms	ACTR\|AIB1\|bHLHe42\|CAGH16\|KAT13B\|p/CIP\|RAC3\|SRC-3\|SRC3\|TNRC16\|TRAM-1
	Gene type	protein_coding
	UniProtAcc	Q9Y6Q9

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Dataset with differentially expressed gene: NCOA3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.303812	1.96e-44
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Plasma cells	-0.403968	4.85e-02
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.278704	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.337415	1.51e-22

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Expression of NCOA3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NCOA3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
NCOA3	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating NCOA3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NCOA3	hsa-miR-137-3p	99.4893	NM_001174087
NCOA3	hsa-miR-8485	98.4605	NM_001174087
NCOA3	hsa-miR-545-3p	98.1154	NM_001174087
NCOA3	hsa-miR-20a-5p	98.0496	NM_001174087
NCOA3	hsa-miR-106b-5p	98.0496	NM_001174087
NCOA3	hsa-miR-3163	97.9211	NM_001174087
NCOA3	hsa-miR-526b-3p	97.475	NM_001174087
NCOA3	hsa-miR-106a-5p	97.475	NM_001174087
NCOA3	hsa-miR-93-5p	97.0387	NM_001174087
NCOA3	hsa-miR-20b-5p	97.0387	NM_001174087
NCOA3	hsa-miR-17-5p	97.0387	NM_001174087
NCOA3	hsa-miR-519d-3p	97.0387	NM_001174087
NCOA3	hsa-miR-4324	97.0052	NM_001174087
NCOA3	hsa-miR-5011-5p	96.773	NM_001174087
NCOA3	hsa-miR-548e-5p	96.5394	NM_001174087
NCOA3	hsa-miR-3613-3p	96.0823	NM_001174087
NCOA3	hsa-miR-4699-3p	95.684	NM_001174087
NCOA3	hsa-miR-190a-3p	95.3071	NM_001174087
NCOA3	hsa-miR-1200	94.8065	NM_001174087
NCOA3	hsa-miR-6511a-5p	93.9245	NM_001174087
NCOA3	hsa-miR-1910-3p	93.9245	NM_001174087
NCOA3	hsa-miR-544b	92.7114	NM_001174087
NCOA3	hsa-miR-12136	91.7009	NM_001174087
NCOA3	hsa-miR-1283	90.7189	NM_001174087
NCOA3	hsa-miR-570-3p	90.5501	NM_001174087
NCOA3	hsa-miR-514b-5p	89.7025	NM_001174087
NCOA3	hsa-miR-513c-5p	89.7025	NM_001174087
NCOA3	hsa-miR-4297	88.2509	NM_001174087
NCOA3	hsa-miR-3664-5p	87.8069	NM_001174087
NCOA3	hsa-miR-216b-5p	86.4038	NM_001174087
NCOA3	hsa-miR-875-3p	85.4469	NM_001174087
NCOA3	hsa-miR-3192-3p	85.1201	NM_001174087
NCOA3	hsa-miR-186-5p	85.0241	NM_001174087
NCOA3	hsa-miR-544a	84.91	NM_001174087
NCOA3	hsa-miR-548m	84.8721	NM_001174087
NCOA3	hsa-miR-4652-3p	84.8334	NM_001174087
NCOA3	hsa-miR-1468-5p	84.775	NM_001174087
NCOA3	hsa-miR-6805-3p	84.7389	NM_001174087
NCOA3	hsa-miR-5691	84.7389	NM_001174087
NCOA3	hsa-miR-4503	84.3504	NM_001174087
NCOA3	hsa-miR-3160-3p	84.2559	NM_001174087
NCOA3	hsa-miR-4482-3p	84.2396	NM_001174087
NCOA3	hsa-miR-6499-3p	83.9639	NM_001174087
NCOA3	hsa-miR-548p	83.8898	NM_001174087
NCOA3	hsa-miR-302e	82.0476	NM_001174087
NCOA3	hsa-miR-9-5p	81.976	NM_001174087
NCOA3	hsa-miR-3116	81.9692	NM_001174087
NCOA3	hsa-miR-6875-3p	81.6164	NM_001174087
NCOA3	hsa-miR-4422	80.7173	NM_001174087
NCOA3	hsa-miR-6844	80.4105	NM_001174087

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Motifs and transcription factors (TFs) regulating NCOA3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NCOA3	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
NCOA3	cisbp__M00249	WT1 (directAnnotation).
NCOA3	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
NCOA3	transfac_pro__M01122	ZNF219 (directAnnotation).
NCOA3	metacluster_151.2	ZNF23 (directAnnotation).
NCOA3	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
NCOA3	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
NCOA3	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
NCOA3	metacluster_7.13	ZFX (directAnnotation).
NCOA3	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
NCOA3	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
NCOA3	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
NCOA3	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
NCOA3	swissregulon__hs__GLIS2	GLIS2 (directAnnotation).
NCOA3	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
NCOA3	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
NCOA3	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
NCOA3	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
NCOA3	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
NCOA3	metacluster_84.2	RARA (directAnnotation).
NCOA3	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
NCOA3	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
NCOA3	transfac_pro__M01253	CNOT3 (directAnnotation).
NCOA3	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
NCOA3	metacluster_3.10	KLF2; KLF4 (directAnnotation).
NCOA3	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
NCOA3	jaspar__MA1721.1	ZNF93 (directAnnotation).
NCOA3	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
NCOA3	swissregulon__hs__CHD1	CHD1 (directAnnotation).
NCOA3	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
NCOA3	jaspar__MA1122.1	TFDP1 (directAnnotation).
NCOA3	cisbp__M00341	PAX6 (directAnnotation).
NCOA3	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
NCOA3	transfac_pro__M01199	TRIM28 (directAnnotation).
NCOA3	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
NCOA3	tfdimers__MD00151	CHURC1 (directAnnotation).
NCOA3	tfdimers__MD00391	KLF4 (directAnnotation).
NCOA3	tfdimers__MD00441	OVOL2; RELA (directAnnotation).
NCOA3	metacluster_163.1	KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF10; KLF10; KLF12; KLF12; KLF12; KLF13; KLF16; KLF17; KLF2; KLF3; KLF3; KLF3; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF5; KLF6; KLF6; KLF6; KLF7; KLF9; KLF9; SALL4; SP1; ZNF148; ZNF148; ZNF526 (directAnnotation). EGR4; KLF1; KLF1; KLF12; KLF12; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF8; KLF9; SP4; SP5; SP5; SP6; SP7; SP8; SP9; ZNF526 (inferredBy_Orthology).
NCOA3	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
NCOA3	cisbp__M00968	MTF2 (directAnnotation).
NCOA3	transfac_pro__M01973	PLAG1 (directAnnotation).
NCOA3	transfac_pro__M12697	ZNF142 (directAnnotation).
NCOA3	metacluster_196.3	NR1H4; NR2F6; PRDM14; ZNF264; ZNF264 (directAnnotation). HNF4A; HNF4G; NR1D1; NR1D1; NR1D1; NR1D2; NR1D2; NR1D2; NR1H2; NR1H2; NR1H2; NR1H3; NR1H3; NR1H3; NR1I2; NR1I2; NR1I2; NR2C1; NR2C2; NR2F2; NR2F6; PPARA; PPARA; PPARA; PPARD; PPARD; PPARD; PPARG; PPARG; PPARG; RARA; RARA; RARA; RARB; RARB; RARB; RORA; RORA; RORA; RORB; RORB; RORB; RORC; RORC; RORC; RXRA; RXRB; RXRG; THRA; THRA; THRA; VDR; VDR; VDR (inferredBy_Orthology).
NCOA3	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
NCOA3	jaspar__MA0748.2	YY2 (directAnnotation).
NCOA3	transfac_pro__M01303	SP1 (directAnnotation).
NCOA3	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
NCOA3	metacluster_3.14	WT1; WT1 (directAnnotation).
NCOA3	metacluster_24.5	ZNF675; ZNF675 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."