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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: NCF1

Summary for NCF1

Gene information	Gene symbol	NCF1
	Ensembl ID	ENSG00000158517
	Entrez ID	653361
	Gene name	neutrophil cytosolic factor 1
	Synonyms	NCF1A\|NOXO2\|p47phox\|SH3PXD1A
	Gene type	protein_coding
	UniProtAcc	P14598

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Dataset with differentially expressed gene: NCF1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Mono/Macro	0.309981	9.79e-28
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	-0.327376	8.23e-31
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	-0.35016	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	-0.424947	1.55e-15
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.266091	1.28e-05
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Plasma cells	-0.306695	1.77e-04
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	Mono/Macro	0.294427	1.74e-43
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Mono/Macro	-0.326287	1.99e-32
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	-0.370517	1.98e-28
GSE162117	patients	Peripheral blood mononuclear cells	Acute myeloid leukemia	Tefractory acute myeloid leukemia (AML)	Targeted therapy	ficlatuzumab	post	cDCs	0.294525	1.65e-06
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	post	Mono/Macro	1.0448	2.39e-02
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Malignant cells	-0.274943	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Mono/Macro	-0.286387	1.02e-10
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Mono/Macro	0.271893	1.96e-07

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Expression of NCF1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to NCF1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating NCF1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
NCF1	hsa-miR-4729	80.6978	NM_000265

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Motifs and transcription factors (TFs) regulating NCF1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
NCF1	hdpi__FLI1	FLI1 (directAnnotation).
NCF1	transfac_pro__M05605	GATA6 (inferredBy_Orthology).
NCF1	metacluster_139.7	XBP1 (directAnnotation). XBP1 (inferredBy_Orthology).
NCF1	transfac_pro__M06905	ZNF585B (directAnnotation).
NCF1	homer__GGAAATTCCC_NFkB-p65-Rel	RELA (inferredBy_Orthology).
NCF1	transfac_pro__M04814	RELA (directAnnotation).
NCF1	transfac_pro__M06629	ZNF578 (directAnnotation).
NCF1	transfac_pro__M04706	RELA (directAnnotation).
NCF1	metacluster_22.27	NFE2L2 (inferredBy_Orthology).
NCF1	jaspar__MA1125.1	ZNF384 (directAnnotation).
NCF1	metacluster_5.1	HIVEP1; HIVEP1; NFAT5; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB2; NFKB2; NFKB2; NFKB2; NFKB2; REL; REL; REL; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELA; RELB; RELB (directAnnotation). NFAT5; NFKB1; NFKB1; NFKB1; NFKB1; NFKB1; NFKB2; NFKB2; NFKB2; REL; REL; REL; REL; RELA; RELA; RELA; RELA; RELA; RELB; RELB; RELB (inferredBy_Orthology).
NCF1	tfdimers__MD00207	HOXA13; PDX1 (directAnnotation).
NCF1	kznf__ZBTB12_Schmitges2016_RCADE	ZBTB12 (directAnnotation).
NCF1	metacluster_35.4	ETV4; ETV4; ETV5; SPI1 (directAnnotation).
NCF1	metacluster_9.12	LHX4 (directAnnotation).
NCF1	transfac_pro__M05856	ZNF565 (directAnnotation).
NCF1	metacluster_23.5	WT1 (directAnnotation).
NCF1	metacluster_82.3	ZNF143 (directAnnotation). ZNF143 (inferredBy_Orthology).
NCF1	metacluster_9.42	LHX3 (inferredBy_Orthology).
NCF1	tfdimers__MD00491	CRX (directAnnotation).
NCF1	transfac_pro__M04897	FOSL1 (directAnnotation).
NCF1	tfdimers__MD00123	E2F1; SOX17 (directAnnotation).
NCF1	metacluster_20.9	TLX2 (directAnnotation).
NCF1	transfac_pro__M06192	ZNF135 (directAnnotation).
NCF1	tfdimers__MD00208	IRF1; LTF (directAnnotation).
NCF1	metacluster_9.43	LHX1 (inferredBy_Orthology).
NCF1	transfac_pro__M06404	ZNF497 (directAnnotation).
NCF1	kznf__CTCF_Rhee2011.3_ChIP-exo	CTCF (directAnnotation).
NCF1	metacluster_46.4	CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPE; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; CEBPG; DBP; DBP; EP300; GATAD2A; HES2 (directAnnotation). CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPA; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPB; CEBPD; CEBPD; CEBPD; CEBPD; CEBPD; CEBPE; CEBPE; CEBPE; CEBPG; CEBPG; HLF; HLF (inferredBy_Orthology).
NCF1	transfac_pro__M05411	ZNF784 (inferredBy_Orthology).
NCF1	transfac_pro__M06149	ZNF132 (directAnnotation).
NCF1	jaspar__MA1958.1	HOXD12 (directAnnotation).
NCF1	tfdimers__MD00007	E2F1; IRF8 (directAnnotation).
NCF1	tfdimers__MD00330	FOXP3; HSF1 (directAnnotation).
NCF1	taipale_tf_pairs__ETV2_HOXA2_NCCGGAAGTMATTA_CAP_repr	ETV2; HOXA2 (directAnnotation).
NCF1	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).
NCF1	taipale_tf_pairs__TEAD4_SPIB_RGAATGCGGAAGTN_CAP_1	SPIB; TEAD4 (directAnnotation).
NCF1	metacluster_2.8	IRF4; IRF5; IRF6; IRF9 (directAnnotation). IRF3; IRF5; IRF5; IRF6 (inferredBy_Orthology).
NCF1	transfac_pro__M12556	ETV4 (directAnnotation).
NCF1	metacluster_130.11	ZNF721 (directAnnotation).
NCF1	metacluster_150.3	LMX1B; LMX1B; LMX1B (directAnnotation).
NCF1	metacluster_184.45	ALX1 (inferredBy_Orthology).
NCF1	metacluster_27.20	ZNF708; ZNF787; ZNF787; ZNF85 (directAnnotation).
NCF1	metacluster_9.26	LHX3 (directAnnotation).
NCF1	transfac_pro__M06953	VAX1 (inferredBy_Orthology).
NCF1	transfac_pro__M06362	ZNF730 (directAnnotation).
NCF1	swissregulon__mm__Nkx2-3	NKX2-3 (inferredBy_Orthology).
NCF1	jaspar__MA0702.2	LMX1A (directAnnotation).
NCF1	transfac_pro__M05472	ZBTB41 (directAnnotation).
NCF1	taipale_tf_pairs__ETV2_HOXB13_NCCGGAAGTYRTAAAN_CAP	ETV2; HOXB13 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."