Dataset | Source | Tissue | Cancer type level1 | Cancer type level2 | Drug type | Regimen | Timepoint | Cell type | avg_log2FC | p_val_adj |
GSE140440 | DU145 and PCÂ cell lines | Cell line | Prostate cancer | Prostate cancer | Chemotherapy | docetaxel | NA | Malignant cells | -0.784737 | 2.53e-10 |
GSE186960 | Panc1 cell line | Cell line | Pancreatic cancer | Pancreatic ductal adenocarcinoma (PDAC) | Chemotherapy | gemcitabine | NA | Malignant cells | -0.30795 | 2.20e-19 |
GSE138267 | CDX | Tumor tissue | Lung cancer | Small cell lung cancer (SCLC) | Chemotherapy | NA | NA | Malignant cells | 0.28843 | 0.00e+00 |
GSE153697 | patients | Bone marrow aspirate | Acute lymphoblastic leukemia | Relapsed B-cell acute lymphoblastic leukemia (B-ALL) | Immunotherapy | anti-CD19 CAR-T | NA | Malignant cells | 0.472286 | 1.27e-33 |
GSE164551 | patients | Bone marrow aspirate | Multiple myeloma | Refractory multiple myeloma (MM) | Immunotherapy | CAR-T | NA | Erythrocytes | -0.303048 | 1.40e-11 |
PMID34715028 | patients | Tumor tissue | Kidney cancer | Clear cell renal cell carcinoma (ccRCC) | Immunotherapy | nivolumab | post | CD4+ T cells | 0.25747 | 1.77e-15 |
PMID34715028 | patients | Tumor tissue | Kidney cancer | Clear cell renal cell carcinoma (ccRCC) | Immunotherapy | nivolumab | post | CD8+ T cells | 0.529525 | 0.00e+00 |
GSE207422_Sin | patients | Tumor tissue | Lung cancer | EGFR/ALK mutation negative non-small cell lung cancer (NSCLC) | Immunotherapy | sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine) | post | CD4+ T cells | 0.323783 | 9.26e-08 |
GSE139386 | H3122 cell line | Cell line | Lung cancer | EML4-ALK fusion-positive non-small cell lung cancer (NSCLC) | Targeted therapy | ceritinib | NA | Malignant cells | -0.558622 | 0.00e+00 |
GSE199333 | patients | Bone marrow aspirate | Acute myeloid leukemia | Primary FLT3-ITD-mutated acute myeloid leukemia (AML) | Targeted therapy | gilteritinib | post | Malignant cells | 0.279752 | 0.00e+00 |
GSE199333 | patients | Bone marrow aspirate | Acute myeloid leukemia | Primary FLT3-ITD-mutated acute myeloid leukemia (AML) | Targeted therapy | gilteritinib | post | Erythrocytes | -0.281316 | 0.00e+00 |
GSE131984_JQ1Pal | SUM159 cell line | Cell line | Breast cancer | Triple-negative breast cancer (TNBC) | Targeted therapy | JQ1 + palbociclib | NA | Malignant cells | 0.277355 | 4.70e-11 |
GSE108397 | 451Lu cell line | Cell line | Melanoma | Melanoma | Targeted therapy | PLX-4720 | NA | Malignant cells | -0.363222 | 0.00e+00 |
GSE115251 | Kelly cell line | Cell line | Neuroblastoma | Neuroblastoma | Targeted therapy | TAE684 | NA | Malignant cells | 0.508943 | 0.00e+00 |
Gene symbol | motif | TF_highConf |
NAP1L4 | metacluster_7.13 | ZFX (directAnnotation). |
NAP1L4 | metacluster_174.2 | CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology). |
NAP1L4 | cisbp__M01863 | ZNF711 (inferredBy_Orthology). |
NAP1L4 | metacluster_151.2 | ZNF23 (directAnnotation). |
NAP1L4 | metacluster_170.2 | KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology). |
NAP1L4 | transfac_pro__M05479 | ZNF580 (directAnnotation). |
NAP1L4 | metacluster_155.23 | BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology). |
NAP1L4 | kznf__ZNF783_Imbeault2017_OM_MEME | ZNF783 (directAnnotation). |
NAP1L4 | metacluster_144.3 | ZNF704; ZNF704 (directAnnotation). |
NAP1L4 | transfac_pro__M06071 | ZNF814 (directAnnotation). |
NAP1L4 | hocomoco__KLF13_HUMAN.H11MO.0.D | KLF13 (directAnnotation). |
NAP1L4 | homer__TWVGGTCCGC_HINFP | HINFP (directAnnotation). |
NAP1L4 | metacluster_135.10 | MBD2; MBD2; MECP2; MECP2 (directAnnotation). |
NAP1L4 | jaspar__MA0079.5 | SP1 (directAnnotation). |
NAP1L4 | taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP | ETV5; HES7 (directAnnotation). |
NAP1L4 | kznf__ZFP57_Imbeault2017_RP_ChIP-seq | ZFP57 (directAnnotation). |
NAP1L4 | kznf__ZNF777_Imbeault2017_RP_ChIP-seq | ZNF777 (directAnnotation). |
NAP1L4 | metacluster_195.2 | EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology). |
NAP1L4 | metacluster_67.2 | ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology). |
NAP1L4 | metacluster_3.14 | WT1; WT1 (directAnnotation). |
NAP1L4 | cisbp__M07938 | E2F1 (directAnnotation). |
NAP1L4 | transfac_pro__M01219 | SP1 (directAnnotation). SP3 (inferredBy_Orthology). |
NAP1L4 | transfac_pro__M07397 | ZNF148 (directAnnotation). |
NAP1L4 | metacluster_131.7 | EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology). |
NAP1L4 | taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth | ZNF281 (directAnnotation). |
NAP1L4 | metacluster_15.2 | E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology). |
NAP1L4 | metacluster_3.11 | SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation). |
NAP1L4 | homer__GGGGGGGG_Maz | MAZ (directAnnotation). |
NAP1L4 | transfac_pro__M01175 | ZBTB7B (directAnnotation). |
NAP1L4 | tfdimers__MD00151 | CHURC1 (directAnnotation). |
NAP1L4 | metacluster_3.7 | SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation). |
NAP1L4 | metacluster_15.1 | E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology). |
NAP1L4 | transfac_pro__M01303 | SP1 (directAnnotation). |
NAP1L4 | metacluster_141.5 | NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology). |
NAP1L4 | swissregulon__hs__CHD1 | CHD1 (directAnnotation). |
NAP1L4 | transfac_pro__M02090 | E2F4 (directAnnotation). |
NAP1L4 | transfac_pro__M01714 | KLF15 (directAnnotation). |
NAP1L4 | hocomoco__PROX1_HUMAN.H11MO.0.D | PROX1 (directAnnotation). |
NAP1L4 | transfac_pro__M02089 | E2F3 (directAnnotation). |
NAP1L4 | metacluster_3.4 | SP1; SP2; SP2; SP3 (directAnnotation). |
NAP1L4 | metacluster_126.3 | LIN28B; LIN28B (directAnnotation). |
NAP1L4 | hocomoco__EGR4_HUMAN.H11MO.0.D | EGR4 (directAnnotation). |
NAP1L4 | metacluster_3.5 | KLF14; KLF15; KLF15; KLF16 (directAnnotation). |
NAP1L4 | homer__GGCGGGAARN_E2F6 | E2F6 (directAnnotation). |
NAP1L4 | transfac_pro__M07436 | WT1 (directAnnotation). |
NAP1L4 | transfac_pro__M02281 | SP1 (directAnnotation). |
NAP1L4 | kznf__ZNF730_Imbeault2017_RP_RCADE | ZNF730 (directAnnotation). |
NAP1L4 | transfac_pro__M02898 | SMAD3 (directAnnotation). |
NAP1L4 | transfac_public__M00491 | PATZ1 (directAnnotation). |
NAP1L4 | transfac_pro__M07461 | KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation). |
1 | "Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618." |
2 | "Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335." |