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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: MYO6

Summary for MYO6

Gene information	Gene symbol	MYO6
	Ensembl ID	ENSG00000196586
	Entrez ID	4646
	Gene name	myosin VI
	Synonyms	DFNA22\|DFNB37\|KIAA0389
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: MYO6

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.42593	2.47e-10
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	1.39916	0.00e+00
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.443785	3.86e-20
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.312601	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-1.20677	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.439746	0.00e+00

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Expression of MYO6 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MYO6

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MYO6

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MYO6	hsa-miR-12136	99.1612	NM_004999
MYO6	hsa-miR-4775	98.6896	NM_001300899
MYO6	hsa-miR-5696	97.645	NM_001300899
MYO6	hsa-miR-5195-3p	97.5244	NM_001300899
MYO6	hsa-miR-145-5p	97.5235	NM_001300899
MYO6	hsa-miR-3148	97.4714	NM_004999
MYO6	hsa-miR-1323	97.3559	NM_004999
MYO6	hsa-miR-4770	96.9	NM_001300899
MYO6	hsa-miR-143-3p	96.9	NM_001300899
MYO6	hsa-miR-548o-3p	96.3785	NM_004999
MYO6	hsa-miR-6088	96.1381	NM_001300899
MYO6	hsa-miR-4729	96.1031	NM_001300899
MYO6	hsa-miR-770-5p	94.3646	NM_001300899
MYO6	hsa-miR-4712-5p	94.3646	NM_001300899
MYO6	hsa-miR-5089-3p	92.1485	NM_001300899
MYO6	hsa-miR-3123	92.0452	NM_001300899
MYO6	hsa-miR-627-3p	91.3875	NM_001300899
MYO6	hsa-miR-508-5p	91.0346	NM_001300899
MYO6	hsa-miR-499b-3p	90.7691	NM_001300899
MYO6	hsa-miR-499a-3p	90.7691	NM_001300899
MYO6	hsa-miR-3925-3p	89.2541	NM_001300899
MYO6	hsa-miR-4708-5p	88.9078	NM_001300899
MYO6	hsa-miR-217-3p	87.7132	NM_004999
MYO6	hsa-miR-3173-3p	87.4892	NM_004999
MYO6	hsa-miR-6811-3p	86.3882	NM_004999
MYO6	hsa-miR-26b-3p	86.3329	NM_001300899
MYO6	hsa-miR-6507-5p	85.5768	NM_004999
MYO6	hsa-miR-590-3p	85.0948	NM_001300899
MYO6	hsa-miR-4641	84.9079	NM_001300899
MYO6	hsa-miR-579-3p	84.3243	NM_001300899
MYO6	hsa-miR-664b-3p	84.3243	NM_001300899
MYO6	hsa-miR-12135	83.882	NM_004999
MYO6	hsa-miR-150-3p	83.8057	NM_004999
MYO6	hsa-miR-6891-5p	83.3881	NM_004999
MYO6	hsa-miR-12118	83.3881	NM_004999
MYO6	hsa-miR-153-5p	83.0175	NM_004999
MYO6	hsa-miR-3692-3p	83.0086	NM_001300899
MYO6	hsa-miR-589-5p	82.9164	NM_004999
MYO6	hsa-miR-1236-3p	82.7336	NM_004999
MYO6	hsa-miR-1303	82.6579	NM_004999
MYO6	hsa-miR-3925-5p	82.465	NM_004999
MYO6	hsa-miR-335-3p	82.1617	NM_004999
MYO6	hsa-miR-494-3p	82.0861	NM_004999
MYO6	hsa-miR-6776-5p	81.3514	NM_004999
MYO6	hsa-miR-766-5p	80.7899	NM_004999
MYO6	hsa-miR-3124-3p	80.5648	NM_004999

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Motifs and transcription factors (TFs) regulating MYO6

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MYO6	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
MYO6	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
MYO6	kznf__ZNF25_Imbeault2017_OM_MEME	ZNF25 (directAnnotation).
MYO6	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
MYO6	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
MYO6	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).
MYO6	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
MYO6	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
MYO6	metacluster_3.14	WT1; WT1 (directAnnotation).
MYO6	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
MYO6	cisbp__M07938	E2F1 (directAnnotation).
MYO6	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
MYO6	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
MYO6	transfac_pro__M07397	ZNF148 (directAnnotation).
MYO6	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
MYO6	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
MYO6	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
MYO6	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
MYO6	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
MYO6	metacluster_7.13	ZFX (directAnnotation).
MYO6	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
MYO6	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
MYO6	transfac_pro__M01175	ZBTB7B (directAnnotation).
MYO6	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
MYO6	tfdimers__MD00151	CHURC1 (directAnnotation).
MYO6	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
MYO6	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
MYO6	transfac_pro__M01303	SP1 (directAnnotation).
MYO6	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
MYO6	swissregulon__hs__CHD1	CHD1 (directAnnotation).
MYO6	transfac_pro__M02090	E2F4 (directAnnotation).
MYO6	transfac_pro__M01714	KLF15 (directAnnotation).
MYO6	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
MYO6	jaspar__MA1122.1	TFDP1 (directAnnotation).
MYO6	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
MYO6	transfac_pro__M02089	E2F3 (directAnnotation).
MYO6	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
MYO6	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
MYO6	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
MYO6	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
MYO6	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
MYO6	transfac_pro__M07436	WT1 (directAnnotation).
MYO6	transfac_pro__M02281	SP1 (directAnnotation).
MYO6	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
MYO6	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
MYO6	metacluster_3.3	KLF10; KLF15; KLF16; KLF9; SP1 (directAnnotation).
MYO6	transfac_pro__M02898	SMAD3 (directAnnotation).
MYO6	transfac_public__M00491	PATZ1 (directAnnotation).
MYO6	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
MYO6	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."