Dataset | Source | Tissue | Cancer type level1 | Cancer type level2 | Drug type | Regimen | Timepoint | Cell type | avg_log2FC | p_val_adj |
GSE186960 | Panc1 cell line | Cell line | Pancreatic cancer | Pancreatic ductal adenocarcinoma (PDAC) | Chemotherapy | gemcitabine | NA | Malignant cells | 0.333164 | 4.00e-25 |
GSE138267 | CDX | Tumor tissue | Lung cancer | Small cell lung cancer (SCLC) | Chemotherapy | NA | NA | Malignant cells | 0.271319 | 0.00e+00 |
GSE169246_PacBlood | patients | Peripheral blood mononuclear cells | Breast cancer | Advanced triple-negative breast cancer (TNBC) | Chemotherapy | paclitaxel | pre | Mono/Macro | 0.25775 | 0.00e+00 |
GSE153697 | patients | Bone marrow aspirate | Acute lymphoblastic leukemia | Relapsed B-cell acute lymphoblastic leukemia (B-ALL) | Immunotherapy | anti-CD19 CAR-T | NA | Malignant cells | -0.49324 | 3.03e-25 |
GSE164551 | patients | Bone marrow aspirate | Multiple myeloma | Refractory multiple myeloma (MM) | Immunotherapy | CAR-T | NA | Mono/Macro | 0.287913 | 3.60e-05 |
GSE189460 | patients | Bone marrow aspirate | Multiple myeloma | Multiple myeloma (MM) | Targeted therapy | bortezomib + melphalan + prednisolone | pre | Malignant cells | 0.416481 | 0.00e+00 |
GSE158457 | PDX cells | Cell line | Acute lymphoblastic leukemia | T-cell acute lymphoblastic leukemia (ALL) | Targeted therapy | dasatinib | NA | Malignant cells | 0.470375 | 0.00e+00 |
GSE199333 | patients | Bone marrow aspirate | Acute myeloid leukemia | Primary FLT3-ITD-mutated acute myeloid leukemia (AML) | Targeted therapy | gilteritinib | post | NK cells | -0.410245 | 0.00e+00 |
GSE199333 | patients | Bone marrow aspirate | Acute myeloid leukemia | Primary FLT3-ITD-mutated acute myeloid leukemia (AML) | Targeted therapy | gilteritinib | post | CD8+ T cells | -0.528258 | 0.00e+00 |
GSE199333 | patients | Bone marrow aspirate | Acute myeloid leukemia | Primary FLT3-ITD-mutated acute myeloid leukemia (AML) | Targeted therapy | gilteritinib | post | Malignant cells | -0.391986 | 0.00e+00 |
GSE199333 | patients | Bone marrow aspirate | Acute myeloid leukemia | Primary FLT3-ITD-mutated acute myeloid leukemia (AML) | Targeted therapy | gilteritinib | pre | B cells | -1.0474 | 7.36e-06 |
GSE161801_IMiD | patients | Bone marrow aspirate | Multiple myeloma | Refractory multiple myeloma (MM) | Targeted therapy | pomalidomide + dexamethasone OR lenalidomide + dexamethasone | pre | Malignant cells | 0.381122 | 0.00e+00 |
GSE161801_IMiD | patients | Bone marrow aspirate | Multiple myeloma | Refractory multiple myeloma (MM) | Targeted therapy | pomalidomide + dexamethasone OR lenalidomide + dexamethasone | pre | B cells | 0.273966 | 2.29e-03 |
Gene symbol | motif | TF_highConf |
MDM4 | taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr | GCM1; SPDEF (directAnnotation). |
MDM4 | transfac_pro__M01219 | SP1 (directAnnotation). SP3 (inferredBy_Orthology). |
MDM4 | transfac_pro__M07397 | ZNF148 (directAnnotation). |
MDM4 | metacluster_131.7 | EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology). |
MDM4 | taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth | ZNF281 (directAnnotation). |
MDM4 | metacluster_15.2 | E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology). |
MDM4 | metacluster_7.13 | ZFX (directAnnotation). |
MDM4 | homer__GGGGGGGG_Maz | MAZ (directAnnotation). |
MDM4 | transfac_pro__M01175 | ZBTB7B (directAnnotation). |
MDM4 | taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth | ZNF460 (directAnnotation). |
MDM4 | tfdimers__MD00151 | CHURC1 (directAnnotation). |
MDM4 | metacluster_15.1 | E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology). |
MDM4 | transfac_pro__M02090 | E2F4 (directAnnotation). |
MDM4 | transfac_pro__M01714 | KLF15 (directAnnotation). |
MDM4 | metacluster_15.3 | E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology). |
MDM4 | hocomoco__PROX1_HUMAN.H11MO.0.D | PROX1 (directAnnotation). |
MDM4 | metacluster_3.14 | WT1; WT1 (directAnnotation). |
MDM4 | metacluster_126.3 | LIN28B; LIN28B (directAnnotation). |
MDM4 | hocomoco__EGR4_HUMAN.H11MO.0.D | EGR4 (directAnnotation). |
MDM4 | metacluster_3.5 | KLF14; KLF15; KLF15; KLF16 (directAnnotation). |
MDM4 | homer__GGCGGGAARN_E2F6 | E2F6 (directAnnotation). |
MDM4 | transfac_pro__M07436 | WT1 (directAnnotation). |
MDM4 | transfac_pro__M02281 | SP1 (directAnnotation). |
MDM4 | taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr | ELF1; GCM1 (directAnnotation). |
MDM4 | transfac_pro__M02898 | SMAD3 (directAnnotation). |
MDM4 | transfac_public__M00491 | PATZ1 (directAnnotation). |
MDM4 | transfac_pro__M07461 | KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation). |
MDM4 | taipale_cyt_meth__CREB1_NRTGACGTN_eDBD_repr | CREB1 (directAnnotation). |
MDM4 | metacluster_155.23 | BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology). |
MDM4 | taipale_tf_pairs__ERF_PITX1_NSCGGANNNNNNGGMTTA_CAP | ERF; PITX1 (directAnnotation). |
MDM4 | tfdimers__MD00217 | LTF; MZF1 (directAnnotation). |
MDM4 | transfac_pro__M06117 | ZNF23 (directAnnotation). |
MDM4 | tfdimers__MD00433 | NKX3-2; ZNF217 (directAnnotation). |
MDM4 | transfac_public__M00123 | MAX; MYC (directAnnotation). |
MDM4 | taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP | ELK1; TBX21 (directAnnotation). |
MDM4 | taipale_tf_pairs__TCF15_NACAYATGNN_HT | TCF15 (directAnnotation). |
MDM4 | jaspar__MA0039.4 | KLF4 (directAnnotation). |
MDM4 | transfac_pro__M04595 | SALL2 (directAnnotation). |
MDM4 | taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr | E2F8; TFAP2C (directAnnotation). |
MDM4 | metacluster_135.10 | MBD2; MBD2; MECP2; MECP2 (directAnnotation). |
MDM4 | dbtfbs__ZBTB10_HEK293_ENCSR004PLU_merged_N1 | ZBTB10 (directAnnotation). |
MDM4 | metacluster_144.8 | ZNF30; ZNF30 (directAnnotation). |
MDM4 | metacluster_23.9 | GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology). |
MDM4 | metacluster_61.1 | DEAF1; DEAF1 (directAnnotation). |
MDM4 | transfac_pro__M04617 | ZBTB7A (directAnnotation). |
MDM4 | transfac_pro__M01973 | PLAG1 (directAnnotation). |
MDM4 | metacluster_151.2 | ZNF23 (directAnnotation). |
MDM4 | cisbp__M01864 | EGR1 (inferredBy_Orthology). |
MDM4 | tfdimers__MD00391 | KLF4 (directAnnotation). |
MDM4 | cisbp__M00139 | ZNF281 (inferredBy_Orthology). |
1 | "Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618." |
2 | "Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335." |