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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: MCFD2

Summary for MCFD2

Gene information	Gene symbol	MCFD2
	Ensembl ID	ENSG00000180398
	Entrez ID	90411
	Gene name	multiple coagulation factor deficiency 2, ER cargo receptor complex subunit
	Synonyms	F5F8D\|LMAN1IP\|SDNSF
	Gene type	protein_coding
	UniProtAcc	Q8NI22

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Dataset with differentially expressed gene: MCFD2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.365571	5.62e-15
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.282696	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.251981	1.03e-09
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.352244	3.40e-12
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.254807	1.39e-13
GSE164897_Vem	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib	NA	Malignant cells	0.299234	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	0.412188	0.00e+00

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Expression of MCFD2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to MCFD2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating MCFD2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
MCFD2	hsa-miR-6809-3p	98.1275	NM_001171506
MCFD2	hsa-miR-200b-3p	97.2026	NM_001171506
MCFD2	hsa-miR-429	97.2026	NM_001171506
MCFD2	hsa-miR-200c-3p	97.2026	NM_001171506
MCFD2	hsa-miR-23c	97.0903	NM_001171506
MCFD2	hsa-miR-23a-3p	97.0903	NM_001171506
MCFD2	hsa-miR-23b-3p	97.0903	NM_001171506
MCFD2	hsa-miR-4753-3p	94.0918	NM_001171506
MCFD2	hsa-miR-4328	93.6914	NM_139279
MCFD2	hsa-miR-4698	92.6578	NM_001171506
MCFD2	hsa-miR-3184-3p	91.0451	NM_139279
MCFD2	hsa-miR-1250-3p	90.9878	NM_139279
MCFD2	hsa-miR-645	90.9366	NM_139279
MCFD2	hsa-miR-186-5p	90.7474	NM_001171506
MCFD2	hsa-miR-4705	90.2922	NM_001171506
MCFD2	hsa-miR-607	89.8855	NM_139279
MCFD2	hsa-miR-1208	88.6237	NM_139279
MCFD2	hsa-miR-509-3p	88.5289	NM_139279
MCFD2	hsa-miR-3133	88.2431	NM_001171506
MCFD2	hsa-miR-8084	87.6714	NM_001171506
MCFD2	hsa-miR-3124-3p	87.4303	NM_139279
MCFD2	hsa-miR-3140-3p	87.3537	NM_139279
MCFD2	hsa-miR-199a-3p	86.7411	NM_001171506
MCFD2	hsa-miR-199b-3p	86.7411	NM_001171506
MCFD2	hsa-miR-5093	85.7871	NM_139279
MCFD2	hsa-miR-4719	84.8233	NM_001171506
MCFD2	hsa-miR-410-3p	84.653	NM_001171506
MCFD2	hsa-miR-6884-3p	84.4337	NM_139279
MCFD2	hsa-miR-1200	82.9209	NM_001171506
MCFD2	hsa-miR-5003-3p	82.7789	NM_139279
MCFD2	hsa-miR-7515	82.2515	NM_139279
MCFD2	hsa-miR-374a-5p	81.957	NM_001171506
MCFD2	hsa-miR-3129-5p	81.9073	NM_001171506
MCFD2	hsa-miR-130b-5p	81.0472	NM_139279
MCFD2	hsa-miR-629-3p	81.0092	NM_139279
MCFD2	hsa-miR-374b-5p	80.7754	NM_001171506
MCFD2	hsa-miR-369-3p	80.6478	NM_001171506
MCFD2	hsa-miR-4478	80.4734	NM_139279
MCFD2	hsa-miR-3185	80.1375	NM_139279

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Motifs and transcription factors (TFs) regulating MCFD2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
MCFD2	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
MCFD2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
MCFD2	metacluster_7.13	ZFX (directAnnotation).
MCFD2	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
MCFD2	cisbp__M00968	MTF2 (directAnnotation).
MCFD2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
MCFD2	cisbp__M00341	PAX6 (directAnnotation).
MCFD2	metacluster_198.3	ZFP64 (directAnnotation).
MCFD2	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
MCFD2	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
MCFD2	cisbp__M00788	ZFY (inferredBy_Orthology).
MCFD2	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
MCFD2	metacluster_175.1	ZNF283 (directAnnotation).
MCFD2	hdpi__ZNF304	ZNF304 (directAnnotation).
MCFD2	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
MCFD2	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
MCFD2	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
MCFD2	transfac_pro__M01199	TRIM28 (directAnnotation).
MCFD2	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
MCFD2	metacluster_151.2	ZNF23 (directAnnotation).
MCFD2	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
MCFD2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
MCFD2	transfac_pro__M03806	ZBTB7C (directAnnotation).
MCFD2	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
MCFD2	cisbp__M02645	ETS1 (directAnnotation).
MCFD2	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
MCFD2	metacluster_33.8	BRCA1; CHD2; CHD2; ETS1; NR3C1; ZBED1; ZBED1; ZBED1; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33 (directAnnotation). CHD2; ZBTB33 (inferredBy_Orthology).
MCFD2	transfac_pro__M06173	ZNF85 (directAnnotation).
MCFD2	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
MCFD2	transfac_pro__M01122	ZNF219 (directAnnotation).
MCFD2	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
MCFD2	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
MCFD2	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
MCFD2	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
MCFD2	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
MCFD2	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
MCFD2	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
MCFD2	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
MCFD2	transfac_pro__M01253	CNOT3 (directAnnotation).
MCFD2	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
MCFD2	metacluster_3.10	KLF2; KLF4 (directAnnotation).
MCFD2	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
MCFD2	jaspar__MA1721.1	ZNF93 (directAnnotation).
MCFD2	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
MCFD2	swissregulon__hs__CHD1	CHD1 (directAnnotation).
MCFD2	transfac_pro__M05479	ZNF580 (directAnnotation).
MCFD2	kznf__ZNF311_Imbeault2017_OM_MEME	ZNF311 (directAnnotation).
MCFD2	jaspar__MA1122.1	TFDP1 (directAnnotation).
MCFD2	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
MCFD2	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
MCFD2	"Antihemophilic factor, human recombinant"	DB00025	biotech
MCFD2	"Lonoctocog alfa"	DB13998	biotech
MCFD2	"Moroctocog alfa"	DB13999	biotech

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."