Dataset | Source | Tissue | Cancer type level1 | Cancer type level2 | Drug type | Regimen | Timepoint | Cell type | avg_log2FC | p_val_adj |
GSE197268_Axi-cel | patients | Peripheral blood mononuclear cells | Acute lymphoblastic leukemia | Large B-cell acute lymphoblastic leukemia (B-ALL) | Immunotherapy | axi-cel (CAR-T) | post | CD8+ T cells | -0.458454 | 0.00e+00 |
GSE197268_Axi-cel | patients | Peripheral blood mononuclear cells | Acute lymphoblastic leukemia | Large B-cell acute lymphoblastic leukemia (B-ALL) | Immunotherapy | axi-cel (CAR-T) | post | CD4+ T cells | -0.261266 | 1.39e-28 |
GSE197268_Axi-cel | patients | Peripheral blood mononuclear cells | Acute lymphoblastic leukemia | Large B-cell acute lymphoblastic leukemia (B-ALL) | Immunotherapy | axi-cel (CAR-T) | pre | CD4+ T cells | 0.265964 | 6.80e-10 |
GSE197268_Tisa-cel | patients | Peripheral blood mononuclear cells | Acute lymphoblastic leukemia | Large B-cell acute lymphoblastic leukemia (B-ALL) | Immunotherapy | tisa-cel (CAR-T) | pre | CD4+ T cells | 0.30722 | 3.06e-32 |
GSE207422_Tor | patients | Tumor tissue | Lung cancer | EGFR/ALK mutation negative non-small cell lung cancer (NSCLC) | Immunotherapy | toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine) | post | CD4+ T cells | -0.419326 | 1.51e-09 |
GSE158457 | PDX cells | Cell line | Acute lymphoblastic leukemia | T-cell acute lymphoblastic leukemia (ALL) | Targeted therapy | dasatinib | NA | Malignant cells | 0.511008 | 0.00e+00 |
GSE199333 | patients | Bone marrow aspirate | Acute myeloid leukemia | Primary FLT3-ITD-mutated acute myeloid leukemia (AML) | Targeted therapy | gilteritinib | post | Erythrocytes | -0.330752 | 0.00e+00 |
GSE199333 | patients | Bone marrow aspirate | Acute myeloid leukemia | Primary FLT3-ITD-mutated acute myeloid leukemia (AML) | Targeted therapy | gilteritinib | post | CD4+ T cells | 0.346667 | 0.00e+00 |
Gene symbol | motif | TF_highConf |
MAL | metacluster_44.20 | NKX3-1 (directAnnotation). |
MAL | tfdimers__MD00399 | ELF5; NFATC3 (directAnnotation). |
MAL | metacluster_44.18 | NKX3-2 (directAnnotation). |
MAL | metacluster_44.21 | NKX3-2 (directAnnotation). |
MAL | metacluster_44.13 | NKX3-1; NKX3-2 (directAnnotation). |
MAL | tfdimers__MD00187 | GATA1; GATA2; GATA3; GATA4; GATA5; GATA6 (directAnnotation). |
MAL | transfac_pro__M06292 | ZNF766 (directAnnotation). |
MAL | metacluster_122.17 | IRF6 (directAnnotation). |
MAL | metacluster_44.19 | NKX3-1 (inferredBy_Orthology). |
MAL | transfac_pro__M01119 | ZBTB33 (directAnnotation). |
MAL | taipale_cyt_meth__LHX6_MTCGTTAN_FL_meth | LHX6 (directAnnotation). |
MAL | hocomoco__PRGR_HUMAN.H11MO.1.A | PGR (directAnnotation). |
MAL | transfac_pro__M07392 | PITX3 (directAnnotation). |
MAL | transfac_pro__M06529 | ZNF596 (directAnnotation). |
MAL | metacluster_44.16 | NKX3-1 (directAnnotation). |
MAL | jaspar__MA1489.1 | FOXN3 (directAnnotation). |
MAL | transfac_pro__M05887 | ZNF837 (directAnnotation). |
MAL | hocomoco__KAISO_HUMAN.H11MO.2.A | ZBTB33 (directAnnotation). |
MAL | swissregulon__mm__Sox5 | SOX5 (inferredBy_Orthology). |
MAL | metacluster_161.2 | LHX8 (directAnnotation). |
MAL | taipale_tf_pairs__CLOCK_EVX1_TAATTANNNNNNCACGTG_CAP_repr | CLOCK; EVX1 (directAnnotation). |
MAL | tfdimers__MD00084 | ARID3A; NKX2-4 (directAnnotation). |
MAL | metacluster_190.3 | IKZF2; IKZF2; ILF2; NFATC1; NFATC2; NFATC3; NFATC4 (directAnnotation). NFATC2 (inferredBy_Orthology). |
MAL | transfac_pro__M06969 | EBF4 (inferredBy_Orthology). |
MAL | transfac_pro__M07607 | NFATC3 (directAnnotation). |
MAL | tfdimers__MD00598 | NKX3-2; TAF6; TBP (directAnnotation). |
MAL | cisbp__M01816 | JUN (inferredBy_Orthology). |
MAL | swissregulon__mm__Nr3c1 | NR3C1 (inferredBy_Orthology). |
MAL | transfac_pro__M06137 | ZNF250 (directAnnotation). |
MAL | transfac_pro__M06119 | ZNF254 (directAnnotation). |
MAL | transfac_public__M00415 | ZEB1 (directAnnotation). |
MAL | hdpi__RFXANK | RFXANK (directAnnotation). |
MAL | transfac_pro__M04844 | MAX (directAnnotation). |
MAL | homer__TAATCCCN_Pitx1 | PITX1 (inferredBy_Orthology). |
MAL | transfac_pro__M06591 | ZNF681 (directAnnotation). |
MAL | tfdimers__MD00478 | SOX10; ZNF217 (directAnnotation). |
MAL | transfac_pro__M02082 | ISL2 (directAnnotation). |
MAL | dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1 | GMEB1 (directAnnotation). |
MAL | transfac_pro__M06569 | ZNF775 (directAnnotation). |
MAL | taipale_tf_pairs__MYBL1_TBX21_AGGTGTGNCSGTTR_CAP_repr | MYBL1; TBX21 (directAnnotation). |
MAL | transfac_pro__M05352 | ZNF692 (inferredBy_Orthology). |
MAL | transfac_pro__M06078 | ZNF878 (directAnnotation). |
MAL | transfac_pro__M06783 | ZNF443 (directAnnotation). |
MAL | tfdimers__MD00035 | MZF1; STAT6 (directAnnotation). |
MAL | metacluster_52.10 | GTF3C2; ZNF436 (directAnnotation). |
MAL | transfac_pro__M06528 | ZNF527 (directAnnotation). |
MAL | taipale_tf_pairs__GCM1_FIGLA_CAGCTGNNNNNNNNNNNTGCGGG_CAP | FIGLA; GCM1 (directAnnotation). |
MAL | transfac_pro__M12458 | PRDM4 (directAnnotation). |
MAL | kznf__ZNF705G_Imbeault2017_OM_MEME | ZNF705G (directAnnotation). |
MAL | transfac_pro__M06547 | ZNF675 (directAnnotation). |
1 | "Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618." |
2 | "Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335." |