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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: M6PR

Summary for M6PR

Gene information	Gene symbol	M6PR
	Ensembl ID	ENSG00000003056
	Entrez ID	4074
	Gene name	mannose-6-phosphate receptor, cation dependent
	Synonyms	CD-M6PR\|CD-MPR
	Gene type	protein_coding
	UniProtAcc	P20645

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Dataset with differentially expressed gene: M6PR

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	0.346132	3.00e-14
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.325268	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	0.269413	3.71e-02
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.402023	8.64e-31
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	CD8+ T cells	0.253583	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.363378	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	0.348904	5.20e-36
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.395707	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	0.541066	0.00e+00
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	pre	Mono/Macro	0.318611	7.97e-05
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.290215	3.82e-11
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.663932	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.391466	2.21e-43

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Expression of M6PR in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to M6PR

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating M6PR

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
M6PR	hsa-miR-204-5p	94.4611	NM_001207024
M6PR	hsa-miR-211-5p	94.4611	NM_001207024
M6PR	hsa-miR-4755-5p	94.2652	NM_001207024
M6PR	hsa-miR-5006-3p	94.2652	NM_001207024
M6PR	hsa-let-7c-3p	94.0976	NM_001207024
M6PR	hsa-miR-199b-5p	92.16	NM_001207024
M6PR	hsa-miR-199a-5p	92.16	NM_001207024
M6PR	hsa-miR-12120	90.4935	NM_001207024
M6PR	hsa-miR-153-5p	89.9093	NM_001207024
M6PR	hsa-miR-4446-5p	88.3981	NM_001207024
M6PR	hsa-miR-10527-5p	88.007	NM_001207024
M6PR	hsa-miR-335-5p	87.7463	NM_001207024
M6PR	hsa-miR-451b	87.5599	NM_001207024
M6PR	hsa-miR-6847-5p	87.0953	NM_001207024
M6PR	hsa-miR-6507-3p	86.6843	NM_001207024
M6PR	hsa-miR-9-5p	86.5122	NM_001207024
M6PR	hsa-miR-623	86.1087	NM_001207024
M6PR	hsa-miR-493-5p	85.3865	NM_001207024
M6PR	hsa-miR-8068	85.2764	NM_001207024
M6PR	hsa-miR-670-5p	84.7281	NM_001207024
M6PR	hsa-let-7g-3p	84.7031	NM_001207024
M6PR	hsa-let-7a-2-3p	84.7031	NM_001207024
M6PR	hsa-miR-4447	83.9337	NM_001207024
M6PR	hsa-miR-4319	83.3777	NM_001207024
M6PR	hsa-miR-125b-5p	83.3777	NM_001207024
M6PR	hsa-miR-125a-5p	83.3777	NM_001207024
M6PR	hsa-miR-3692-3p	83.2781	NM_001207024
M6PR	hsa-miR-10a-5p	83.1681	NM_001207024
M6PR	hsa-miR-10b-5p	83.1681	NM_001207024
M6PR	hsa-miR-6841-5p	81.7773	NM_001207024
M6PR	hsa-miR-6769b-3p	81.7487	NM_001207024
M6PR	hsa-miR-3183	81.7487	NM_001207024
M6PR	hsa-miR-4723-3p	81.7487	NM_001207024

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Motifs and transcription factors (TFs) regulating M6PR

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
M6PR	hdpi__ETV4	ETV4 (directAnnotation).
M6PR	transfac_pro__M05628	ZNF735 (directAnnotation).
M6PR	transfac_pro__M04826	EP300 (directAnnotation).
M6PR	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
M6PR	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
M6PR	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
M6PR	metacluster_34.4	ETS1; ETS1; ETS1; HCFC1; SIX5; SIX5; SIX5; SIX5; SMARCC2; SMARCC2; THAP11; THAP11; ZNF143; ZNF143; ZNF143; ZNF143 (directAnnotation). TBX2; THAP11; THAP11; ZNF143 (inferredBy_Orthology).
M6PR	transfac_pro__M04748	GABPA (directAnnotation).
M6PR	swissregulon__hs__ELF2	ELF2 (directAnnotation).
M6PR	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
M6PR	hdpi__TP73	TP73 (directAnnotation).
M6PR	taipale_tf_pairs__TEAD4_ETV4_RCCGGAAATRCC_CAP	ETV4; TEAD4 (directAnnotation).
M6PR	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
M6PR	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
M6PR	transfac_pro__M04862	NRF1 (directAnnotation).
M6PR	swissregulon__hs__ETV6	ETV6 (directAnnotation).
M6PR	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP_repr	ERG; TEAD4 (directAnnotation).
M6PR	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
M6PR	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
M6PR	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
M6PR	jaspar__MA1933.1	SREBF2 (directAnnotation).
M6PR	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
M6PR	taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP	ELK1; FOXO1 (directAnnotation).
M6PR	taipale_tf_pairs__ETV2_RFX5_NNNTTCCGSNNNNGCAACNN_CAP_repr	ETV2; RFX5 (directAnnotation).
M6PR	taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr	ELK1; EOMES (directAnnotation).
M6PR	taipale_tf_pairs__ETV2_DRGX_RSCGGAWRYATTA_CAP_repr	DRGX; ETV2 (directAnnotation).
M6PR	taipale_tf_pairs__ELK1_TEF_NSCGGAWNTTACGTAAN_CAP	ELK1; TEF (directAnnotation).
M6PR	taipale_tf_pairs__ELK1_FOXI1_WGTTKMCGGAWRTN_CAP	ELK1; FOXI1 (directAnnotation).
M6PR	metacluster_198.3	ZFP64 (directAnnotation).
M6PR	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
M6PR	hdpi__ZNF304	ZNF304 (directAnnotation).
M6PR	tfdimers__MD00302	IRF7; IRF8 (directAnnotation).
M6PR	taipale_tf_pairs__GCM1_FIGLA_CAGCTGNNNNNNNNTGCGGG_CAP	FIGLA; GCM1 (directAnnotation).
M6PR	metacluster_9.47	PAX7 (inferredBy_Orthology).
M6PR	metacluster_166.5	ERG; ETV2; FLI1 (directAnnotation).
M6PR	jaspar__MA1956.1	FOXO1 (directAnnotation).
M6PR	jaspar__MA1946.1	FOXI1 (directAnnotation).
M6PR	homer__NCCACGTG_c-Myc	MYC (directAnnotation).
M6PR	metacluster_174.6	NFYA; NFYB; NFYB; NFYC (directAnnotation).
M6PR	taipale_tf_pairs__ERF_CEBPD_RSMGGAANTTGCGYAAN_CAP	CEBPD; ERF (directAnnotation).
M6PR	transfac_pro__M05668	ZNF154 (directAnnotation).
M6PR	transfac_pro__M06506	ZFP62 (directAnnotation).
M6PR	transfac_pro__M06639	ZNF559 (directAnnotation).
M6PR	transfac_pro__M05895	ZNF454 (directAnnotation).
M6PR	metacluster_57.5	ZKSCAN5 (directAnnotation).
M6PR	cisbp__M01815	CEBPE (inferredBy_Orthology).
M6PR	transfac_pro__M00793	YY1 (directAnnotation).
M6PR	transfac_pro__M01242	MTF1 (directAnnotation).
M6PR	metacluster_172.19	HMGA2 (directAnnotation).
M6PR	transfac_pro__M04913	ZBTB7A (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
M6PR	"1-3 Sugar Ring of Pentamannosyl 6-Phosphate"	DB02755	small molecule
M6PR	"Alglucosidase alfa"	DB01272	biotech
M6PR	"alpha-D-mannose 6-phosphate"	DB02900	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."