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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: LMAN1

Summary for LMAN1

Gene information	Gene symbol	LMAN1
	Ensembl ID	ENSG00000074695
	Entrez ID	3998
	Gene name	lectin, mannose binding 1
	Synonyms	ERGIC-53\|ERGIC53\|F5F8D\|FMFD1\|gp58\|MCFD1\|MR60
	Gene type	protein_coding
	UniProtAcc	P49257

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Dataset with differentially expressed gene: LMAN1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.452024	2.59e-37
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.311964	2.86e-14
GSE212217	patients	Peripheral blood mononuclear cells	Endometrial cancer	Epigenetic MMRd endometrial carcinoma	Immunotherapy	pembrolizumab	post	Plasma cells	0.435891	1.07e-03
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	0.399262	4.63e-11
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.899353	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.266156	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.326677	1.90e-13
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.403857	4.20e-18
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Malignant cells	-0.515808	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-1.04981	0.00e+00
GSE164897_Vem	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib	NA	Malignant cells	0.255234	0.00e+00

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Expression of LMAN1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to LMAN1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating LMAN1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
LMAN1	hsa-miR-548az-5p	95.2557	NM_005570
LMAN1	hsa-miR-548t-5p	95.2557	NM_005570
LMAN1	hsa-miR-32-3p	94.7994	NM_005570
LMAN1	hsa-miR-548ao-5p	94.01	NM_005570
LMAN1	hsa-miR-548ax	94.01	NM_005570
LMAN1	hsa-miR-876-5p	93.1246	NM_005570
LMAN1	hsa-miR-7161-3p	92.5442	NM_005570
LMAN1	hsa-miR-5585-5p	92.3742	NM_005570
LMAN1	hsa-miR-3167	92.1979	NM_005570
LMAN1	hsa-miR-34a-5p	91.6487	NM_005570
LMAN1	hsa-miR-449a	91.6487	NM_005570
LMAN1	hsa-miR-449b-5p	91.4094	NM_005570
LMAN1	hsa-miR-34c-5p	91.4094	NM_005570
LMAN1	hsa-miR-513b-3p	91.0381	NM_005570
LMAN1	hsa-miR-7-2-3p	89.0004	NM_005570
LMAN1	hsa-miR-7-1-3p	89.0004	NM_005570
LMAN1	hsa-miR-3125	88.7213	NM_005570
LMAN1	hsa-miR-4477a	88.6356	NM_005570
LMAN1	hsa-miR-7702	87.5807	NM_005570
LMAN1	hsa-miR-3916	87.3955	NM_005570
LMAN1	hsa-miR-6859-5p	87.3955	NM_005570
LMAN1	hsa-miR-616-3p	86.9425	NM_005570
LMAN1	hsa-miR-6715b-5p	86.6119	NM_005570
LMAN1	hsa-miR-4269	86.6119	NM_005570
LMAN1	hsa-miR-4695-3p	85.6128	NM_005570
LMAN1	hsa-miR-3671	85.2797	NM_005570
LMAN1	hsa-miR-877-5p	84.943	NM_005570
LMAN1	hsa-miR-335-3p	84.5663	NM_005570
LMAN1	hsa-miR-520d-5p	84.327	NM_005570
LMAN1	hsa-miR-524-5p	84.327	NM_005570
LMAN1	hsa-miR-3059-5p	84.1364	NM_005570
LMAN1	hsa-miR-646	83.7682	NM_005570
LMAN1	hsa-miR-138-5p	82.7424	NM_005570
LMAN1	hsa-miR-4719	80.2779	NM_005570
LMAN1	hsa-miR-513c-5p	80.2175	NM_005570

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Motifs and transcription factors (TFs) regulating LMAN1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
LMAN1	transfac_pro__M06035	ZNF749 (directAnnotation).
LMAN1	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
LMAN1	hdpi__TP73	TP73 (directAnnotation).
LMAN1	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
LMAN1	transfac_pro__M04826	EP300 (directAnnotation).
LMAN1	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
LMAN1	cisbp__M02645	ETS1 (directAnnotation).
LMAN1	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
LMAN1	hdpi__ETV4	ETV4 (directAnnotation).
LMAN1	transfac_pro__M01298	MECP2 (directAnnotation).
LMAN1	metacluster_22.13	MAFK (inferredBy_Orthology).
LMAN1	transfac_pro__M05605	GATA6 (inferredBy_Orthology).
LMAN1	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
LMAN1	transfac_pro__M06643	ZNF583 (directAnnotation).
LMAN1	metacluster_10.30	MXI1 (inferredBy_Orthology).
LMAN1	metacluster_139.7	XBP1 (directAnnotation). XBP1 (inferredBy_Orthology).
LMAN1	transfac_pro__M05513	ZNF641 (inferredBy_Orthology).
LMAN1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
LMAN1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
LMAN1	metacluster_160.20	JUND; PRDM15 (directAnnotation).
LMAN1	cisbp__M00341	PAX6 (directAnnotation).
LMAN1	metacluster_198.3	ZFP64 (directAnnotation).
LMAN1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
LMAN1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
LMAN1	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
LMAN1	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
LMAN1	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
LMAN1	transfac_pro__M03806	ZBTB7C (directAnnotation).
LMAN1	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
LMAN1	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
LMAN1	taipale_tf_pairs__FOXO1_ETV1_RCCGGAWGTKKN_CAP	ETV1; FOXO1 (directAnnotation).
LMAN1	jaspar__MA0748.2	YY2 (directAnnotation).
LMAN1	metacluster_182.10	ZFX (directAnnotation).
LMAN1	hdpi__ELF2	ELF2 (directAnnotation).
LMAN1	metacluster_183.4	ETS1 (inferredBy_Orthology).
LMAN1	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
LMAN1	transfac_pro__M00492	STAT1 (directAnnotation).
LMAN1	transfac_pro__M04848	TAF1 (directAnnotation).
LMAN1	metacluster_157.2	ATF3; ATF3; ATF3; BACH1; BACH1; BACH1; BACH2; BACH2; BACH2; BACH2; BATF; BATF; BCL11A; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JDP2; JDP2; JDP2; JDP2; JDP2; JDP2; JDP2; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; JUND; JUND; JUND; JUND; MAF; MAFB; MAFF; MAFG; MAFK; NFE2; NFE2; NFE2; NFE2; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2; NFE2L3; ZNF3; ZSCAN5C (directAnnotation). FOSL1; JUN; JUN; JUN; JUNB; JUNB; JUND (inferredBy_Orthology).
LMAN1	metacluster_22.34	BACH2 (directAnnotation).
LMAN1	metacluster_22.18	BACH2 (inferredBy_Orthology).
LMAN1	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
LMAN1	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
LMAN1	tfdimers__MD00483	ZBTB14 (directAnnotation).
LMAN1	cisbp__M07938	E2F1 (directAnnotation).
LMAN1	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
LMAN1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
LMAN1	jaspar__MA1122.1	TFDP1 (directAnnotation).
LMAN1	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
LMAN1	transfac_pro__M06384	ZNF551 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
LMAN1	"Antihemophilic factor, human recombinant"	DB00025	biotech
LMAN1	"Lonoctocog alfa"	DB13998	biotech
LMAN1	"Moroctocog alfa"	DB13999	biotech

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."