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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: LIMA1

Summary for LIMA1

Gene information	Gene symbol	LIMA1
	Ensembl ID	ENSG00000050405
	Entrez ID	51474
	Gene name	LIM domain and actin binding 1
	Synonyms	EPLIN
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: LIMA1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.569642	1.14e-21
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.351553	1.31e-16
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.496543	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	0.271157	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	0.512725	0.00e+00

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Expression of LIMA1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to LIMA1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating LIMA1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
LIMA1	hsa-miR-520f-5p	96.4275	NM_001113546
LIMA1	hsa-miR-3675-3p	96.4044	NM_001113546
LIMA1	hsa-miR-106b-5p	94.4559	NM_001113546
LIMA1	hsa-miR-20a-5p	94.4559	NM_001113546
LIMA1	hsa-miR-20b-5p	93.6421	NM_001113546
LIMA1	hsa-miR-526b-3p	93.6421	NM_001113546
LIMA1	hsa-miR-106a-5p	93.6421	NM_001113546
LIMA1	hsa-miR-519d-3p	93.6421	NM_001113546
LIMA1	hsa-miR-93-5p	93.6421	NM_001113546
LIMA1	hsa-miR-17-5p	93.6421	NM_001113546
LIMA1	hsa-miR-216b-5p	93.635	NM_001113546
LIMA1	hsa-miR-548c-3p	92.3171	NM_001113546
LIMA1	hsa-miR-3942-3p	90.8393	NM_001113546
LIMA1	hsa-miR-10522-5p	90.4878	NM_001113546
LIMA1	hsa-miR-33a-3p	87.9503	NM_001113546
LIMA1	hsa-miR-6768-3p	87.788	NM_001113546
LIMA1	hsa-miR-5696	87.7408	NM_001113546
LIMA1	hsa-miR-2117	87.4849	NM_001113546
LIMA1	hsa-miR-519b-3p	86.4548	NM_001113546
LIMA1	hsa-miR-519c-3p	86.4548	NM_001113546
LIMA1	hsa-miR-519a-3p	86.4548	NM_001113546
LIMA1	hsa-miR-499a-5p	85.7433	NM_001113546
LIMA1	hsa-miR-6886-3p	84.956	NM_001113546
LIMA1	hsa-miR-938	84.956	NM_001113546
LIMA1	hsa-miR-7161-5p	84.1032	NM_001113546
LIMA1	hsa-miR-6868-5p	83.6451	NM_001113546
LIMA1	hsa-miR-3662	82.9086	NM_001113546
LIMA1	hsa-miR-4693-5p	82.8279	NM_001113546
LIMA1	hsa-miR-6505-5p	81.8572	NM_001113546
LIMA1	hsa-miR-548u	81.8544	NM_001113546
LIMA1	hsa-miR-5585-3p	81.1843	NM_001113546
LIMA1	hsa-miR-1301-3p	81.1352	NM_001113546
LIMA1	hsa-miR-5047	81.1352	NM_001113546
LIMA1	hsa-miR-892a	80.0096	NM_001113546

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Motifs and transcription factors (TFs) regulating LIMA1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
LIMA1	transfac_pro__M06074	ZNF732 (directAnnotation).
LIMA1	jaspar__MA1106.1	HIF1A (directAnnotation).
LIMA1	metacluster_135.11	NR2C2 (directAnnotation).
LIMA1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
LIMA1	tfdimers__MD00038	TFAP2C (directAnnotation).
LIMA1	metacluster_7.13	ZFX (directAnnotation).
LIMA1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
LIMA1	cisbp__M00968	MTF2 (directAnnotation).
LIMA1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
LIMA1	metacluster_160.20	JUND; PRDM15 (directAnnotation).
LIMA1	cisbp__M00341	PAX6 (directAnnotation).
LIMA1	metacluster_198.3	ZFP64 (directAnnotation).
LIMA1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
LIMA1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
LIMA1	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
LIMA1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
LIMA1	cisbp__M00788	ZFY (inferredBy_Orthology).
LIMA1	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
LIMA1	metacluster_175.1	ZNF283 (directAnnotation).
LIMA1	hdpi__ZNF304	ZNF304 (directAnnotation).
LIMA1	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
LIMA1	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
LIMA1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
LIMA1	transfac_pro__M01199	TRIM28 (directAnnotation).
LIMA1	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
LIMA1	metacluster_151.2	ZNF23 (directAnnotation).
LIMA1	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
LIMA1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
LIMA1	transfac_pro__M03806	ZBTB7C (directAnnotation).
LIMA1	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
LIMA1	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
LIMA1	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
LIMA1	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
LIMA1	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
LIMA1	transfac_pro__M04826	EP300 (directAnnotation).
LIMA1	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
LIMA1	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
LIMA1	metacluster_33.8	BRCA1; CHD2; CHD2; ETS1; NR3C1; ZBED1; ZBED1; ZBED1; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33 (directAnnotation). CHD2; ZBTB33 (inferredBy_Orthology).
LIMA1	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
LIMA1	transfac_pro__M04794	TAF1 (directAnnotation).
LIMA1	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
LIMA1	transfac_pro__M04862	NRF1 (directAnnotation).
LIMA1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
LIMA1	taipale_tf_pairs__FOXO1_ETV1_RCCGGAWGTKKN_CAP	ETV1; FOXO1 (directAnnotation).
LIMA1	jaspar__MA0748.2	YY2 (directAnnotation).
LIMA1	metacluster_182.10	ZFX (directAnnotation).
LIMA1	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
LIMA1	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
LIMA1	taipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAP	ELK3; HOXB2 (directAnnotation).
LIMA1	taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP	ELK1; FOXO1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."