Dataset | Source | Tissue | Cancer type level1 | Cancer type level2 | Drug type | Regimen | Timepoint | Cell type | avg_log2FC | p_val_adj |
GSE140440 | DU145 and PCÂ cell lines | Cell line | Prostate cancer | Prostate cancer | Chemotherapy | docetaxel | NA | Malignant cells | 1.34619 | 1.46e-03 |
GSE138267 | CDX | Tumor tissue | Lung cancer | Small cell lung cancer (SCLC) | Chemotherapy | NA | NA | Malignant cells | 0.467882 | 0.00e+00 |
GSE169246_PacBlood | patients | Peripheral blood mononuclear cells | Breast cancer | Advanced triple-negative breast cancer (TNBC) | Chemotherapy | paclitaxel | post | Mono/Macro | -0.371504 | 0.00e+00 |
GSE169246_PacBlood | patients | Peripheral blood mononuclear cells | Breast cancer | Advanced triple-negative breast cancer (TNBC) | Chemotherapy | paclitaxel | pre | cDCs | 0.358481 | 9.07e-09 |
GSE169246_PacTissue | patients | Tumor tissue | Breast cancer | Advanced triple-negative breast cancer (TNBC) | Chemotherapy | paclitaxel | pre | Mono/Macro | 0.632338 | 2.35e-19 |
GSE197268_Axi-cel | patients | Peripheral blood mononuclear cells | Acute lymphoblastic leukemia | Large B-cell acute lymphoblastic leukemia (B-ALL) | Immunotherapy | axi-cel (CAR-T) | post | cDCs | 0.540283 | 5.10e-07 |
GSE164551 | patients | Bone marrow aspirate | Multiple myeloma | Refractory multiple myeloma (MM) | Immunotherapy | CAR-T | NA | Mono/Macro | -0.678758 | 0.00e+00 |
GSE207422_Tor | patients | Tumor tissue | Lung cancer | EGFR/ALK mutation negative non-small cell lung cancer (NSCLC) | Immunotherapy | toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine) | post | Mono/Macro | 0.85198 | 7.18e-21 |
GSE207422_Tor | patients | Tumor tissue | Lung cancer | EGFR/ALK mutation negative non-small cell lung cancer (NSCLC) | Immunotherapy | toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine) | post | Malignant cells | 0.696926 | 6.25e-18 |
GSE139386 | H3122 cell line | Cell line | Lung cancer | EML4-ALK fusion-positive non-small cell lung cancer (NSCLC) | Targeted therapy | ceritinib | NA | Malignant cells | 0.380617 | 0.00e+00 |
GSE162117 | patients | Peripheral blood mononuclear cells | Acute myeloid leukemia | Tefractory acute myeloid leukemia (AML) | Targeted therapy | ficlatuzumab | post | cDCs | -0.462498 | 1.30e-35 |
GSE199333 | patients | Bone marrow aspirate | Acute myeloid leukemia | Primary FLT3-ITD-mutated acute myeloid leukemia (AML) | Targeted therapy | gilteritinib | post | Malignant cells | -0.97673 | 0.00e+00 |
GSE131984_JQ1Pac | SUM159 cell line | Cell line | Breast cancer | Triple-negative breast cancer (TNBC) | Targeted therapy | JQ1 + paclitaxel | NA | Malignant cells | -0.27985 | 2.04e-07 |
Gene symbol | motif | TF_highConf |
KLF4 | taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr | GCM1; SPDEF (directAnnotation). |
KLF4 | transfac_pro__M01219 | SP1 (directAnnotation). SP3 (inferredBy_Orthology). |
KLF4 | transfac_pro__M07397 | ZNF148 (directAnnotation). |
KLF4 | metacluster_131.7 | EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology). |
KLF4 | metacluster_131.4 | EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation). |
KLF4 | taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth | ZNF281 (directAnnotation). |
KLF4 | metacluster_15.2 | E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology). |
KLF4 | metacluster_3.11 | SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation). |
KLF4 | homer__GGGGGGGG_Maz | MAZ (directAnnotation). |
KLF4 | transfac_pro__M01175 | ZBTB7B (directAnnotation). |
KLF4 | taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth | ZNF460 (directAnnotation). |
KLF4 | tfdimers__MD00151 | CHURC1 (directAnnotation). |
KLF4 | metacluster_3.7 | SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation). |
KLF4 | metacluster_15.1 | E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology). |
KLF4 | transfac_pro__M01303 | SP1 (directAnnotation). |
KLF4 | swissregulon__hs__CHD1 | CHD1 (directAnnotation). |
KLF4 | transfac_pro__M02090 | E2F4 (directAnnotation). |
KLF4 | transfac_pro__M01714 | KLF15 (directAnnotation). |
KLF4 | hocomoco__PROX1_HUMAN.H11MO.0.D | PROX1 (directAnnotation). |
KLF4 | transfac_pro__M02089 | E2F3 (directAnnotation). |
KLF4 | metacluster_3.14 | WT1; WT1 (directAnnotation). |
KLF4 | metacluster_3.4 | SP1; SP2; SP2; SP3 (directAnnotation). |
KLF4 | metacluster_126.3 | LIN28B; LIN28B (directAnnotation). |
KLF4 | hocomoco__EGR4_HUMAN.H11MO.0.D | EGR4 (directAnnotation). |
KLF4 | metacluster_3.5 | KLF14; KLF15; KLF15; KLF16 (directAnnotation). |
KLF4 | cisbp__M07938 | E2F1 (directAnnotation). |
KLF4 | homer__GGCGGGAARN_E2F6 | E2F6 (directAnnotation). |
KLF4 | transfac_pro__M07436 | WT1 (directAnnotation). |
KLF4 | transfac_pro__M02281 | SP1 (directAnnotation). |
KLF4 | taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr | ELF1; GCM1 (directAnnotation). |
KLF4 | kznf__ZNF730_Imbeault2017_RP_RCADE | ZNF730 (directAnnotation). |
KLF4 | transfac_pro__M02898 | SMAD3 (directAnnotation). |
KLF4 | transfac_public__M00491 | PATZ1 (directAnnotation). |
KLF4 | transfac_pro__M07461 | KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation). |
KLF4 | taipale_tf_pairs__ATF4_TEF_RNMTGATGCAATN_CAP | ATF4; TEF (directAnnotation). |
KLF4 | taipale_tf_pairs__ATF4_CEBPD_NGATGATGCAATNN_CAP | ATF4; CEBPD (directAnnotation). |
KLF4 | taipale_tf_pairs__ATF4_CEBPB_NNATGAYGCAAYN_CAP | ATF4; CEBPB (directAnnotation). |
KLF4 | metacluster_52.11 | ZNF184 (directAnnotation). |
KLF4 | metacluster_195.2 | EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology). |
KLF4 | hocomoco__KLF13_HUMAN.H11MO.0.D | KLF13 (directAnnotation). |
KLF4 | kznf__ZBTB14_Schmitges2016_RCADE | ZBTB14 (directAnnotation). |
KLF4 | transfac_pro__M04617 | ZBTB7A (directAnnotation). |
KLF4 | kznf__ZNF529_Imbeault2017_RP_ChIP-seq | ZNF529 (directAnnotation). |
KLF4 | taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth | E2F2 (directAnnotation). |
KLF4 | transfac_pro__M07387 | ZBTB7A (directAnnotation). |
KLF4 | transfac_pro__M00716 | ZBTB14 (directAnnotation). |
KLF4 | hdpi__HIP2 | UBE2K (directAnnotation). |
KLF4 | metacluster_170.2 | KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology). |
KLF4 | transfac_pro__M04893 | TAF1 (directAnnotation). |
KLF4 | transfac_pro__M03876 | ZBTB33 (directAnnotation). |
1 | "Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618." |
2 | "Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335." |