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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: JMJD1C

Summary for JMJD1C

Gene information	Gene symbol	JMJD1C
	Ensembl ID	ENSG00000171988
	Entrez ID	221037
	Gene name	jumonji domain containing 1C
	Synonyms	DKFZp761F0118\|FLJ14374\|KDM3C\|KIAA1380\|TRIP8
	Gene type	protein_coding
	UniProtAcc	Q15652

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Dataset with differentially expressed gene: JMJD1C

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.616765	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.31016	2.10e-44
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.470843	0.00e+00
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.694634	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.663162	9.81e-45
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	-0.286524	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.553324	0.00e+00
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	-0.374742	1.86e-16
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.385553	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	CD8+ T cells	-0.259203	9.29e-13
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.386811	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.328758	3.05e-38
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.320655	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.620307	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.940699	2.68e-37

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Expression of JMJD1C in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to JMJD1C

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating JMJD1C

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
JMJD1C	hsa-miR-3065-5p	99.4734	NM_001318153
JMJD1C	hsa-miR-7159-5p	99.0791	NM_001318153
JMJD1C	hsa-miR-2681-5p	98.9272	NM_001318153
JMJD1C	hsa-miR-96-5p	98.6831	NM_001282948
JMJD1C	hsa-miR-1271-5p	97.8128	NM_001282948
JMJD1C	hsa-miR-12133	97.8128	NM_001282948
JMJD1C	hsa-let-7c-3p	97.6488	NM_001282948
JMJD1C	hsa-miR-590-3p	95.8459	NM_001318153
JMJD1C	hsa-miR-6073	95.6051	NM_001282948
JMJD1C	hsa-miR-3688-3p	94.0899	NM_001318153
JMJD1C	hsa-miR-6507-3p	94.0379	NM_001318153
JMJD1C	hsa-miR-4307	93.212	NM_001318153
JMJD1C	hsa-miR-190a-3p	93.0796	NM_001282948
JMJD1C	hsa-miR-3606-5p	92.4852	NM_001282948
JMJD1C	hsa-let-7a-2-3p	92.2133	NM_001282948
JMJD1C	hsa-miR-138-5p	91.6715	NM_001282948
JMJD1C	hsa-miR-8069	91.3836	NM_001318153
JMJD1C	hsa-let-7g-3p	90.8506	NM_001282948
JMJD1C	hsa-miR-499b-3p	89.9341	NM_001318153
JMJD1C	hsa-miR-499a-3p	89.9341	NM_001318153
JMJD1C	hsa-miR-182-5p	89.2899	NM_001282948
JMJD1C	hsa-miR-376c-3p	89.282	NM_001318153
JMJD1C	hsa-miR-7978	89.0537	NM_001282948
JMJD1C	hsa-miR-548g-3p	88.957	NM_001282948
JMJD1C	hsa-miR-338-5p	88.615	NM_001282948
JMJD1C	hsa-miR-4762-3p	88.5188	NM_001318153
JMJD1C	hsa-miR-142-3p	88.4319	NM_001282948
JMJD1C	hsa-miR-3924	87.5165	NM_001318153
JMJD1C	hsa-miR-208a-5p	87.5141	NM_001282948
JMJD1C	hsa-miR-208b-5p	87.5141	NM_001282948
JMJD1C	hsa-miR-512-3p	85.4182	NM_001282948
JMJD1C	hsa-miR-5588-5p	83.9014	NM_001318153
JMJD1C	hsa-miR-4720-5p	83.9014	NM_001318153
JMJD1C	hsa-miR-4799-3p	83.9014	NM_001318153
JMJD1C	hsa-miR-33a-3p	83.7645	NM_001318153
JMJD1C	hsa-miR-4325	83.3417	NM_001318153
JMJD1C	hsa-miR-379-3p	82.7394	NM_001318153
JMJD1C	hsa-miR-411-3p	82.7394	NM_001318153
JMJD1C	hsa-miR-369-3p	82.6636	NM_001282948
JMJD1C	hsa-miR-4524a-3p	82.2794	NM_001318153
JMJD1C	hsa-miR-4742-5p	82.1308	NM_001282948
JMJD1C	hsa-miR-302d-5p	81.7937	NM_001318153
JMJD1C	hsa-miR-302b-5p	81.7937	NM_001318153
JMJD1C	hsa-miR-7852-3p	81.6321	NM_001282948
JMJD1C	hsa-miR-5689	81.1254	NM_001282948
JMJD1C	hsa-miR-1252-3p	80.7428	NM_001318153
JMJD1C	hsa-miR-23a-3p	80.5374	NM_001282948
JMJD1C	hsa-miR-23b-3p	80.5374	NM_001282948
JMJD1C	hsa-miR-23c	80.5374	NM_001282948

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Motifs and transcription factors (TFs) regulating JMJD1C

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
JMJD1C	taipale_tf_pairs__ATF4_TEF_RNMTGATGCAATN_CAP	ATF4; TEF (directAnnotation).
JMJD1C	taipale_tf_pairs__ATF4_CEBPD_NGATGATGCAATNN_CAP	ATF4; CEBPD (directAnnotation).
JMJD1C	metacluster_156.2	ATF3; ATF4; ATF4; ATF4; ATF4; ATF4; ATF4; CEBPG; CEBPG; DDIT3; MYC (directAnnotation). ATF4; ATF4; ATF4; CEBPG; DDIT3 (inferredBy_Orthology).
JMJD1C	transfac_pro__M06035	ZNF749 (directAnnotation).
JMJD1C	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
JMJD1C	kznf__ZNF282_Imbeault2017_OM_RCADE	ZNF282 (directAnnotation).
JMJD1C	transfac_pro__M05788	ZNF569 (inferredBy_Orthology).
JMJD1C	taipale_tf_pairs__ATF4_CEBPB_NNATGAYGCAAYN_CAP	ATF4; CEBPB (directAnnotation).
JMJD1C	jaspar__MA1596.1	ZNF460 (directAnnotation).
JMJD1C	metacluster_52.11	ZNF184 (directAnnotation).
JMJD1C	metacluster_7.8	ZBTB7A; ZNF28 (directAnnotation).
JMJD1C	metacluster_35.7	HINFP (inferredBy_Orthology).
JMJD1C	metacluster_98.1	ZNF524 (directAnnotation).
JMJD1C	taipale_tf_pairs__ETV2_SOX15_RSCGGAANNNNNNNYWTTGT_CAP_repr	ETV2; SOX15 (directAnnotation).
JMJD1C	kznf__ZNF25_Imbeault2017_OM_MEME	ZNF25 (directAnnotation).
JMJD1C	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).
JMJD1C	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
JMJD1C	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
JMJD1C	metacluster_163.1	KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF10; KLF10; KLF12; KLF12; KLF12; KLF13; KLF16; KLF17; KLF2; KLF3; KLF3; KLF3; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF5; KLF6; KLF6; KLF6; KLF7; KLF9; KLF9; SALL4; SP1; ZNF148; ZNF148; ZNF526 (directAnnotation). EGR4; KLF1; KLF1; KLF12; KLF12; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF8; KLF9; SP4; SP5; SP5; SP6; SP7; SP8; SP9; ZNF526 (inferredBy_Orthology).
JMJD1C	transfac_pro__M01783	SP2 (directAnnotation).
JMJD1C	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
JMJD1C	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
JMJD1C	cisbp__M00341	PAX6 (directAnnotation).
JMJD1C	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
JMJD1C	metacluster_111.3	ATF1; ATF3; CREB1; CREB1; CREB1; CREB1; CREB1; CREM; CREM; CREM; CREM; E4F1; E4F1 (directAnnotation). CREB1; CREB1; CREM; JDP2 (inferredBy_Orthology).
JMJD1C	transfac_pro__M01253	CNOT3 (directAnnotation).
JMJD1C	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
JMJD1C	metacluster_7.13	ZFX (directAnnotation).
JMJD1C	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
JMJD1C	cisbp__M00968	MTF2 (directAnnotation).
JMJD1C	transfac_pro__M04817	ZBTB33 (directAnnotation).
JMJD1C	taipale__YY2_DBD_NNCCGCCATNW_repr	YY2 (directAnnotation).
JMJD1C	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
JMJD1C	transfac_pro__M02089	E2F3 (directAnnotation).
JMJD1C	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
JMJD1C	jaspar__MA0748.2	YY2 (directAnnotation).
JMJD1C	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
JMJD1C	taipale_tf_pairs__ERF_PITX1_NSCGGANNNNNNGGMTTA_CAP	ERF; PITX1 (directAnnotation).
JMJD1C	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
JMJD1C	metacluster_22.37	BACH1 (directAnnotation).
JMJD1C	metacluster_22.35	MAFK (directAnnotation).
JMJD1C	jaspar__MA1125.1	ZNF384 (directAnnotation).
JMJD1C	kznf__CTCF_Rhee2011.2_ChIP-exo	CTCF (directAnnotation).
JMJD1C	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
JMJD1C	metacluster_22.39	NFE2L2 (directAnnotation).
JMJD1C	metacluster_137.2	ATF3; BACH2; BATF; BATF; BATF; BATF; BATF3; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSB; FOSB; FOSB; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; INSM2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; SMARCC1 (directAnnotation). ATF3; ATF3; BATF; FOS; FOSB; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUND; JUND; JUND; JUND (inferredBy_Orthology).
JMJD1C	tfdimers__MD00276	IRF1; STAT6 (directAnnotation).
JMJD1C	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
JMJD1C	transfac_pro__M04916	TAF1 (directAnnotation).
JMJD1C	metacluster_135.11	NR2C2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."