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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: JCHAIN

Summary for JCHAIN

Gene information	Gene symbol	JCHAIN
	Ensembl ID	ENSG00000132465
	Entrez ID	3512
	Gene name	joining chain of multimeric IgA and IgM
	Synonyms	IGCJ\|IGJ\|JCH
	Gene type	protein_coding
	UniProtAcc	P01591

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Dataset with differentially expressed gene: JCHAIN

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	B cells	0.316021	1.13e-15
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Plasma cells	0.783341	5.17e-19
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.339999	1.18e-08
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	pDCs	0.882684	3.21e-03
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Plasma cells	-0.699231	2.86e-24
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	B cells	0.344029	8.08e-31
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	B cells	0.29301	1.48e-35
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Plasma cells	-1.09468	7.93e-06
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Plasma cells	0.61744	7.37e-32
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	B cells	0.498104	0.00e+00
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Plasma cells	-0.838452	9.83e-13
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Mono/Macro	1.31003	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Progenitors	1.07545	2.42e-02
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	cDCs	1.13874	9.35e-07
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Erythrocytes	0.640552	2.65e-11
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	NK cells	0.958012	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	-0.674187	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	CD4+ T cells	1.13665	0.00e+00
GSE161195	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	DARA-KRD (daratumumab + carfilzomib + lenalidomide + dexamethasone)	post	Malignant cells	0.972238	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-1.59171	0.00e+00
GSE152469	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	NA	Malignant cells	0.47971	0.00e+00

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Expression of JCHAIN in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to JCHAIN

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating JCHAIN

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
JCHAIN	hsa-miR-3613-3p	95.5908	NM_144646
JCHAIN	hsa-miR-4684-5p	95.1572	NM_144646
JCHAIN	hsa-miR-935	88.729	NM_144646
JCHAIN	hsa-miR-2117	88.5074	NM_144646
JCHAIN	hsa-miR-5187-3p	88.4508	NM_144646
JCHAIN	hsa-miR-520b-5p	88.0908	NM_144646
JCHAIN	hsa-miR-519a-2-5p	88.0908	NM_144646
JCHAIN	hsa-miR-3123	87.9874	NM_144646
JCHAIN	hsa-miR-607	85.465	NM_144646
JCHAIN	hsa-miR-5089-3p	85.3793	NM_144646
JCHAIN	hsa-miR-944	85.3448	NM_144646
JCHAIN	hsa-miR-491-3p	81.7847	NM_144646
JCHAIN	hsa-miR-6737-3p	81.3034	NM_144646
JCHAIN	hsa-miR-7157-3p	81.3034	NM_144646
JCHAIN	hsa-miR-5008-3p	81.3034	NM_144646

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Motifs and transcription factors (TFs) regulating JCHAIN

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
JCHAIN	metacluster_130.15	ARID5B; ARID5B; BPTF (directAnnotation).
JCHAIN	taipale__IRF7_DBD_RAANCGAAAWTCGNTTY_repr	IRF7 (directAnnotation).
JCHAIN	homer__GGCVGTTR_MYB	MYB (inferredBy_Orthology).
JCHAIN	metacluster_113.3	MYBL1; MYBL1; MYBL2; MYBL2; OVOL1; OVOL2 (directAnnotation). MYB; MYBL1; MYBL1; MYBL1; MYBL1; MYBL2; OVOL1 (inferredBy_Orthology).
JCHAIN	c2h2_zfs__M0393	KLF9 (inferredBy_Orthology).
JCHAIN	transfac_pro__M06614	ZNF594 (directAnnotation).
JCHAIN	kznf__ZFP90_Imbeault2017_RP_RCADE	ZFP90 (directAnnotation).
JCHAIN	taipale_cyt_meth__NR4A1_NAAAGGTCAN_eDBD_1	NR4A1 (directAnnotation).
JCHAIN	transfac_public__M00480	TOPORS (directAnnotation).
JCHAIN	taipale_tf_pairs__PITX1_EOMES_GGATTANNARGTGTKN_CAP_repr	EOMES; PITX1 (directAnnotation).
JCHAIN	transfac_pro__M05408	ZNF438 (directAnnotation).
JCHAIN	metacluster_155.34	PRDM4 (directAnnotation).
JCHAIN	tfdimers__MD00351	IRF8; RFX1; RFX2; RFX3; RFX4; RFX5; RFXANK; RFXAP (directAnnotation).
JCHAIN	transfac_pro__M06554	ZNF483 (directAnnotation).
JCHAIN	dbtfbs__ZNF660_HEK293_ENCSR283DOU_merged_N1	ZNF660 (directAnnotation).
JCHAIN	transfac_pro__M06117	ZNF23 (directAnnotation).
JCHAIN	transfac_pro__M05521	ZNF398 (directAnnotation).
JCHAIN	transfac_pro__M05996	ZNF180 (directAnnotation).
JCHAIN	transfac_pro__M06159	ZNF83 (directAnnotation).
JCHAIN	hdpi__ETS1	ETS1 (directAnnotation).
JCHAIN	metacluster_85.2	ZNF274; ZNF585A (directAnnotation).
JCHAIN	hocomoco__ZN490_HUMAN.H11MO.0.C	ZNF490 (directAnnotation).
JCHAIN	kznf__ZNF124_Imbeault2017_RP_RCADE	ZNF124 (directAnnotation).
JCHAIN	metacluster_48.4	GFI1; GFI1; GFI1B; GFI1B; GFI1B (directAnnotation). GFI1; GFI1 (inferredBy_Orthology).
JCHAIN	transfac_pro__M06423	ZNF571 (directAnnotation).
JCHAIN	transfac_pro__M05550	SNAPC4 (inferredBy_Orthology).
JCHAIN	transfac_pro__M06284	ZNF74 (directAnnotation).
JCHAIN	swissregulon__hs__MYB	MYB (directAnnotation).
JCHAIN	tfdimers__MD00302	IRF7; IRF8 (directAnnotation).
JCHAIN	transfac_pro__M06370	ZNF585A (directAnnotation).
JCHAIN	tfdimers__MD00147	ELF5; TFAP2C (directAnnotation).
JCHAIN	taipale_tf_pairs__ETV5_FOXI1_TGTTGNCGGAWRN_CAP	ETV5; FOXI1 (directAnnotation).
JCHAIN	taipale_tf_pairs__TEAD4_ETV1_RSCGGAAATRCM_CAP	ETV1; TEAD4 (directAnnotation).
JCHAIN	transfac_pro__M06615	ZNF597 (directAnnotation).
JCHAIN	transfac_pro__M06360	ZNF626 (directAnnotation).
JCHAIN	homer__GGAAATTCCC_NFkB-p65-Rel	RELA (inferredBy_Orthology).
JCHAIN	transfac_pro__M05542	SNAPC4 (directAnnotation).
JCHAIN	transfac_pro__M05931	ZNF556 (directAnnotation).
JCHAIN	transfac_pro__M01081	ZNF628 (directAnnotation).
JCHAIN	transfac_pro__M06646	ZNF607 (directAnnotation).
JCHAIN	stark__RCGCMATTW	YY1 (inferredBy_Orthology).
JCHAIN	transfac_pro__M06775	ZNF391 (directAnnotation).
JCHAIN	metacluster_108.2	ZNF286A (directAnnotation).
JCHAIN	transfac_pro__M06364	ZNF841 (directAnnotation).
JCHAIN	transfac_pro__M06966	E4F1 (inferredBy_Orthology).
JCHAIN	metacluster_23.10	FOXO4 (inferredBy_Orthology).
JCHAIN	transfac_pro__M07214	GATA3 (directAnnotation).
JCHAIN	hdpi__ZNF323	ZSCAN31 (directAnnotation).
JCHAIN	hocomoco__NKX61_MOUSE.H11MO.1.A	NKX6-1 (inferredBy_Orthology).
JCHAIN	metacluster_140.3	NKX2-3; NKX2-5; NKX2-8 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
JCHAIN	"Zinc acetate"	DB14487	small molecule
JCHAIN	"Zinc chloride"	DB14533	small molecule
JCHAIN	"Zinc sulfate, unspecified form"	DB14548	small molecule
JCHAIN	"Zinc"	DB01593	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."