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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: ITGAV

Summary for ITGAV

Gene information	Gene symbol	ITGAV
	Ensembl ID	ENSG00000138448
	Entrez ID	3685
	Gene name	integrin subunit alpha V
	Synonyms	CD51\|MSK8\|VNRA\|VTNR
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: ITGAV

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.486106	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.362119	3.55e-23
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.617685	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.440902	7.56e-31
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.484585	1.82e-25
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.515718	1.73e-02

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Expression of ITGAV in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ITGAV

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ITGAV

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ITGAV	hsa-miR-142-5p	99.0356	NM_002210
ITGAV	hsa-miR-5590-3p	99.035	NM_002210
ITGAV	hsa-miR-548c-3p	98.7657	NM_001144999
ITGAV	hsa-miR-92b-3p	98.6449	NM_001144999
ITGAV	hsa-miR-92a-3p	98.6449	NM_001144999
ITGAV	hsa-miR-32-5p	98.6449	NM_001144999
ITGAV	hsa-miR-4282	98.5903	NM_001144999
ITGAV	hsa-miR-551b-5p	98.5839	NM_002210
ITGAV	hsa-miR-367-3p	98.2627	NM_001144999
ITGAV	hsa-miR-363-3p	98.2627	NM_001144999
ITGAV	hsa-miR-25-3p	98.2627	NM_001144999
ITGAV	hsa-miR-548ar-3p	97.5436	NM_002210
ITGAV	hsa-miR-548a-3p	97.5286	NM_002210
ITGAV	hsa-miR-548az-3p	97.5206	NM_002210
ITGAV	hsa-miR-548e-3p	97.5206	NM_002210
ITGAV	hsa-miR-548f-3p	97.5206	NM_002210
ITGAV	hsa-miR-548bc	97.5206	NM_002210
ITGAV	hsa-miR-3529-3p	97.2922	NM_002210
ITGAV	hsa-miR-2115-3p	96.3986	NM_002210
ITGAV	hsa-miR-3163	96.2768	NM_002210
ITGAV	hsa-miR-300	96.1687	NM_002210
ITGAV	hsa-miR-381-3p	96.1687	NM_002210
ITGAV	hsa-miR-607	95.6704	NM_001144999
ITGAV	hsa-miR-142-3p	94.7424	NM_001144999
ITGAV	hsa-miR-559	94.4363	NM_001144999
ITGAV	hsa-miR-548w	93.2565	NM_001144999
ITGAV	hsa-miR-548ay-5p	93.2565	NM_001144999
ITGAV	hsa-miR-548j-5p	93.2565	NM_001144999
ITGAV	hsa-miR-548c-5p	93.2565	NM_001144999
ITGAV	hsa-miR-548d-5p	93.2565	NM_001144999
ITGAV	hsa-miR-548o-5p	93.2565	NM_001144999
ITGAV	hsa-miR-548au-5p	93.2565	NM_001144999
ITGAV	hsa-miR-548b-5p	93.2565	NM_001144999
ITGAV	hsa-miR-548ae-5p	93.2565	NM_001144999
ITGAV	hsa-miR-548ak	93.2565	NM_001144999
ITGAV	hsa-miR-548as-5p	93.2565	NM_001144999
ITGAV	hsa-miR-548a-5p	93.2565	NM_001144999
ITGAV	hsa-miR-548i	93.2565	NM_001144999
ITGAV	hsa-miR-548y	93.2565	NM_001144999
ITGAV	hsa-miR-548ar-5p	93.2565	NM_001144999
ITGAV	hsa-miR-548aq-5p	93.2565	NM_001144999
ITGAV	hsa-miR-548h-5p	93.2565	NM_001144999
ITGAV	hsa-miR-548ap-5p	93.2565	NM_001144999
ITGAV	hsa-miR-548ad-5p	93.2565	NM_001144999
ITGAV	hsa-miR-548bb-5p	93.2565	NM_001144999
ITGAV	hsa-miR-548ab	93.2565	NM_001144999
ITGAV	hsa-miR-548am-5p	93.2565	NM_001144999
ITGAV	hsa-miR-153-5p	92.242	NM_002210
ITGAV	hsa-miR-340-5p	92.0458	NM_001144999
ITGAV	hsa-miR-380-3p	91.8333	NM_002210

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Motifs and transcription factors (TFs) regulating ITGAV

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ITGAV	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
ITGAV	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
ITGAV	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
ITGAV	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
ITGAV	transfac_pro__M04826	EP300 (directAnnotation).
ITGAV	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
ITGAV	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
ITGAV	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
ITGAV	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
ITGAV	hdpi__ETV4	ETV4 (directAnnotation).
ITGAV	transfac_pro__M04866	HDAC2 (directAnnotation).
ITGAV	jaspar__MA1122.1	TFDP1 (directAnnotation).
ITGAV	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
ITGAV	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
ITGAV	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
ITGAV	cisbp__M01815	CEBPE (inferredBy_Orthology).
ITGAV	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
ITGAV	taipale_cyt_meth__CREB1_NRTGACGTN_eDBD_repr	CREB1 (directAnnotation).
ITGAV	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
ITGAV	transfac_pro__M04916	TAF1 (directAnnotation).
ITGAV	metacluster_111.5	E4F1; E4F1 (directAnnotation).
ITGAV	metacluster_135.11	NR2C2 (directAnnotation).
ITGAV	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
ITGAV	tfdimers__MD00038	TFAP2C (directAnnotation).
ITGAV	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
ITGAV	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
ITGAV	cisbp__M00968	MTF2 (directAnnotation).
ITGAV	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
ITGAV	metacluster_160.20	JUND; PRDM15 (directAnnotation).
ITGAV	cisbp__M00341	PAX6 (directAnnotation).
ITGAV	metacluster_198.3	ZFP64 (directAnnotation).
ITGAV	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
ITGAV	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
ITGAV	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
ITGAV	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
ITGAV	cisbp__M00788	ZFY (inferredBy_Orthology).
ITGAV	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
ITGAV	metacluster_175.1	ZNF283 (directAnnotation).
ITGAV	hdpi__ZNF304	ZNF304 (directAnnotation).
ITGAV	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
ITGAV	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
ITGAV	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
ITGAV	transfac_pro__M01199	TRIM28 (directAnnotation).
ITGAV	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
ITGAV	metacluster_151.2	ZNF23 (directAnnotation).
ITGAV	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
ITGAV	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ITGAV	transfac_pro__M03806	ZBTB7C (directAnnotation).
ITGAV	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
ITGAV	metacluster_174.6	NFYA; NFYB; NFYB; NFYC (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
ITGAV	"Antithymocyte immunoglobulin (rabbit)"	DB00098	biotech
ITGAV	"Levothyroxine"	DB00451	small molecule
ITGAV	"PLN-74809"	DB16515	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."