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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ITGA6

Summary for ITGA6

Gene information	Gene symbol	ITGA6
	Ensembl ID	ENSG00000091409
	Entrez ID	3655
	Gene name	integrin subunit alpha 6
	Synonyms	CD49f
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: ITGA6

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.801645	5.61e-03
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.41067	2.04e-22
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.380921	8.78e-20
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.327323	5.08e-06
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.28618	0.00e+00
GSE149214	PC9 cell line	Cell line	Lung cancer	EGFR-mutated non-small cell lung cancer (NSCLC)	Targeted therapy	erlotinib	NA	Malignant cells	-0.441949	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.421573	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.439184	1.46e-21

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Expression of ITGA6 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ITGA6

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ITGA6

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ITGA6	hsa-let-7b-3p	99.3503	NM_000210
ITGA6	hsa-let-7a-3p	99.3503	NM_000210
ITGA6	hsa-miR-98-3p	99.3503	NM_000210
ITGA6	hsa-let-7f-1-3p	99.3503	NM_000210
ITGA6	hsa-miR-141-3p	97.9496	NM_001316306
ITGA6	hsa-miR-200a-3p	97.9496	NM_001316306
ITGA6	hsa-miR-590-3p	96.9103	NM_001079818
ITGA6	hsa-miR-3140-5p	96.862	NM_000210
ITGA6	hsa-miR-6516-5p	95.8791	NM_001079818
ITGA6	hsa-miR-30e-5p	95.7389	NM_000210
ITGA6	hsa-miR-30d-5p	95.7389	NM_000210
ITGA6	hsa-miR-30c-5p	95.7389	NM_000210
ITGA6	hsa-miR-30a-5p	95.7389	NM_000210
ITGA6	hsa-miR-30b-5p	95.7389	NM_000210
ITGA6	hsa-miR-4729	94.7444	NM_001079818
ITGA6	hsa-miR-186-5p	94.5227	NM_000210
ITGA6	hsa-miR-92a-3p	94.1227	NM_000210
ITGA6	hsa-miR-32-5p	94.1227	NM_000210
ITGA6	hsa-miR-92b-3p	94.1227	NM_000210
ITGA6	hsa-miR-367-3p	94.0623	NM_000210
ITGA6	hsa-miR-363-3p	94.0623	NM_000210
ITGA6	hsa-miR-25-3p	94.0623	NM_000210
ITGA6	hsa-miR-1297	92.51	NM_000210
ITGA6	hsa-miR-5692a	91.8362	NM_001079818
ITGA6	hsa-miR-19b-3p	91.7607	NM_000210
ITGA6	hsa-miR-19a-3p	91.7607	NM_000210
ITGA6	hsa-miR-6844	91.4573	NM_000210
ITGA6	hsa-miR-105-5p	91.3633	NM_001079818
ITGA6	hsa-miR-3133	90.5805	NM_000210
ITGA6	hsa-miR-6793-3p	90.4551	NM_001079818
ITGA6	hsa-miR-9-5p	89.8518	NM_000210
ITGA6	hsa-miR-6760-3p	89.5422	NM_000210
ITGA6	hsa-miR-216b-3p	89.0602	NM_001079818
ITGA6	hsa-miR-4775	88.7626	NM_001079818
ITGA6	hsa-miR-1267	88.3041	NM_001079818
ITGA6	hsa-miR-323b-5p	88.2592	NM_001079818
ITGA6	hsa-miR-410-5p	88.2592	NM_001079818
ITGA6	hsa-miR-494-5p	88.2592	NM_001079818
ITGA6	hsa-miR-4762-3p	88.0363	NM_000210
ITGA6	hsa-miR-222-5p	87.9785	NM_000210
ITGA6	hsa-miR-26a-5p	87.9636	NM_000210
ITGA6	hsa-miR-26b-5p	87.9636	NM_000210
ITGA6	hsa-miR-1179	86.6635	NM_000210
ITGA6	hsa-miR-381-3p	86.1793	NM_001079818
ITGA6	hsa-miR-300	86.1793	NM_001079818
ITGA6	hsa-miR-5087	86.0249	NM_001079818
ITGA6	hsa-miR-4666a-3p	85.8822	NM_001079818
ITGA6	hsa-miR-335-3p	85.8809	NM_000210
ITGA6	hsa-miR-5682	85.6742	NM_000210
ITGA6	hsa-miR-340-5p	85.312	NM_001079818

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Motifs and transcription factors (TFs) regulating ITGA6

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ITGA6	metacluster_151.2	ZNF23 (directAnnotation).
ITGA6	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
ITGA6	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
ITGA6	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
ITGA6	transfac_pro__M06071	ZNF814 (directAnnotation).
ITGA6	transfac_pro__M05628	ZNF735 (directAnnotation).
ITGA6	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
ITGA6	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
ITGA6	taipale_tf_pairs__GCM1_SPDEF_RTRSKGGCGGANNNNNNATCCNNN_CAP_repr	GCM1; SPDEF (directAnnotation).
ITGA6	jaspar__MA0079.5	SP1 (directAnnotation).
ITGA6	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
ITGA6	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
ITGA6	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
ITGA6	transfac_pro__M04617	ZBTB7A (directAnnotation).
ITGA6	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
ITGA6	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
ITGA6	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
ITGA6	transfac_pro__M07387	ZBTB7A (directAnnotation).
ITGA6	transfac_pro__M07436	WT1 (directAnnotation).
ITGA6	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
ITGA6	transfac_pro__M00716	ZBTB14 (directAnnotation).
ITGA6	swissregulon__hs__CHD1	CHD1 (directAnnotation).
ITGA6	hdpi__HIP2	UBE2K (directAnnotation).
ITGA6	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
ITGA6	transfac_pro__M04893	TAF1 (directAnnotation).
ITGA6	transfac_pro__M03876	ZBTB33 (directAnnotation).
ITGA6	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
ITGA6	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
ITGA6	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
ITGA6	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ITGA6	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
ITGA6	metacluster_50.1	BATF; BATF; BATF; BATF; BNC2; FOS; FOSB; FOSL1; FOSL1; IRF4; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; SMAD2; SMAD3 (directAnnotation). BATF; BATF; BATF; FOS; FOSL1; FOSL2; JDP2; JUN; JUN; JUND (inferredBy_Orthology).
ITGA6	taipale_tf_pairs__TEAD4_HOXB13_CTCGTAAAATGYN_CAP_repr	HOXB13; TEAD4 (directAnnotation).
ITGA6	transfac_pro__M05483	ZBTB1 (directAnnotation).
ITGA6	transfac_pro__M05852	ZNF689 (directAnnotation).
ITGA6	transfac_pro__M04856	BATF (directAnnotation).
ITGA6	transfac_pro__M06314	ZNF239 (directAnnotation).
ITGA6	dbtfbs__SETDB1_HEK293_ENCSR348AGV_merged_N1	SETDB1 (directAnnotation).
ITGA6	swissregulon__hs__DBP	DBP (directAnnotation).
ITGA6	taipale_tf_pairs__GCM2_ONECUT2_RTRCGGGNNNNNNATCRATN_CAP_repr	GCM2; ONECUT2 (directAnnotation).
ITGA6	transfac_pro__M06035	ZNF749 (directAnnotation).
ITGA6	metacluster_137.2	ATF3; BACH2; BATF; BATF; BATF; BATF; BATF3; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSB; FOSB; FOSB; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; INSM2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; SMARCC1 (directAnnotation). ATF3; ATF3; BATF; FOS; FOSB; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUND; JUND; JUND; JUND (inferredBy_Orthology).
ITGA6	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
ITGA6	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
ITGA6	transfac_public__M00024	E2F1 (directAnnotation).
ITGA6	transfac_pro__M04950	EGR1 (directAnnotation).
ITGA6	taipale_tf_pairs__TFAP2C_MAX_TNSCCNNNGGSNNNCACGTGN_CAP_repr	MAX; TFAP2C (directAnnotation).
ITGA6	metacluster_135.11	NR2C2 (directAnnotation).
ITGA6	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
ITGA6	cisbp__M00968	MTF2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."