Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ITGA2

Summary for ITGA2

Gene information	Gene symbol	ITGA2
	Ensembl ID	ENSG00000164171
	Entrez ID	3673
	Gene name	integrin subunit alpha 2
	Synonyms	CD49B
	Gene type	protein_coding
	UniProtAcc	P17301

Top

Dataset with differentially expressed gene: ITGA2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	2.82721	1.69e-24
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-1.19835	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.84749	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.746285	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	0.709094	0.00e+00

Top

Expression of ITGA2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to ITGA2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating ITGA2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ITGA2	hsa-miR-3679-3p	99.6371	NM_002203
ITGA2	hsa-miR-4328	98.3306	NM_002203
ITGA2	hsa-miR-3163	97.4424	NM_002203
ITGA2	hsa-miR-374a-5p	96.0201	NM_002203
ITGA2	hsa-miR-8068	95.571	NM_002203
ITGA2	hsa-miR-374b-5p	95.4098	NM_002203
ITGA2	hsa-miR-3924	91.1366	NM_002203
ITGA2	hsa-miR-4446-5p	90.3179	NM_002203
ITGA2	hsa-miR-5089-5p	90.2038	NM_002203
ITGA2	hsa-miR-18b-5p	87.5111	NM_002203
ITGA2	hsa-miR-18a-5p	87.5111	NM_002203
ITGA2	hsa-miR-4735-3p	87.3796	NM_002203
ITGA2	hsa-miR-208b-5p	87.2824	NM_002203
ITGA2	hsa-miR-208a-5p	87.2824	NM_002203
ITGA2	hsa-miR-3190-3p	86.4928	NM_002203
ITGA2	hsa-miR-890	86.1196	NM_002203
ITGA2	hsa-miR-4772-3p	85.0493	NM_002203
ITGA2	hsa-miR-2681-5p	84.2107	NM_002203
ITGA2	hsa-miR-548az-5p	83.5869	NM_002203
ITGA2	hsa-miR-548t-5p	83.5869	NM_002203
ITGA2	hsa-miR-3201	83.5204	NM_002203
ITGA2	hsa-miR-664a-3p	83.3521	NM_002203
ITGA2	hsa-miR-582-5p	83.3337	NM_002203
ITGA2	hsa-miR-551b-5p	82.3575	NM_002203
ITGA2	hsa-miR-6079	82.0224	NM_002203
ITGA2	hsa-miR-4775	81.8957	NM_002203
ITGA2	hsa-miR-575	81.4822	NM_002203
ITGA2	hsa-miR-4676-5p	81.4822	NM_002203
ITGA2	hsa-miR-19b-3p	80.9666	NM_002203
ITGA2	hsa-miR-19a-3p	80.9666	NM_002203
ITGA2	hsa-miR-4791	80.8583	NM_002203
ITGA2	hsa-miR-6833-5p	80.698	NM_002203
ITGA2	hsa-miR-4682	80.204	NM_002203

Page: 1

Top

Motifs and transcription factors (TFs) regulating ITGA2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ITGA2	taipale_tf_pairs__ATF4_TEF_RNMTGATGCAATN_CAP	ATF4; TEF (directAnnotation).
ITGA2	taipale_tf_pairs__ATF4_CEBPD_NGATGATGCAATNN_CAP	ATF4; CEBPD (directAnnotation).
ITGA2	metacluster_156.2	ATF3; ATF4; ATF4; ATF4; ATF4; ATF4; ATF4; CEBPG; CEBPG; DDIT3; MYC (directAnnotation). ATF4; ATF4; ATF4; CEBPG; DDIT3 (inferredBy_Orthology).
ITGA2	taipale_tf_pairs__ATF4_CEBPB_NNATGAYGCAAYN_CAP	ATF4; CEBPB (directAnnotation).
ITGA2	metacluster_52.11	ZNF184 (directAnnotation).
ITGA2	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
ITGA2	transfac_pro__M04617	ZBTB7A (directAnnotation).
ITGA2	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
ITGA2	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
ITGA2	transfac_pro__M07387	ZBTB7A (directAnnotation).
ITGA2	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
ITGA2	transfac_pro__M00716	ZBTB14 (directAnnotation).
ITGA2	swissregulon__hs__CHD1	CHD1 (directAnnotation).
ITGA2	hdpi__HIP2	UBE2K (directAnnotation).
ITGA2	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
ITGA2	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
ITGA2	transfac_pro__M03876	ZBTB33 (directAnnotation).
ITGA2	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
ITGA2	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
ITGA2	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
ITGA2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
ITGA2	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
ITGA2	cisbp__M00968	MTF2 (directAnnotation).
ITGA2	metacluster_160.20	JUND; PRDM15 (directAnnotation).
ITGA2	cisbp__M00341	PAX6 (directAnnotation).
ITGA2	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
ITGA2	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
ITGA2	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
ITGA2	metacluster_175.1	ZNF283 (directAnnotation).
ITGA2	hdpi__ZNF304	ZNF304 (directAnnotation).
ITGA2	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
ITGA2	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
ITGA2	transfac_pro__M01199	TRIM28 (directAnnotation).
ITGA2	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
ITGA2	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
ITGA2	transfac_pro__M03806	ZBTB7C (directAnnotation).
ITGA2	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
ITGA2	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
ITGA2	jaspar__MA0748.2	YY2 (directAnnotation).
ITGA2	hdpi__TP73	TP73 (directAnnotation).
ITGA2	hdpi__FLI1	FLI1 (directAnnotation).
ITGA2	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
ITGA2	transfac_pro__M06305	ZNF583 (inferredBy_Orthology).
ITGA2	transfac_pro__M05697	ZNF235 (directAnnotation).
ITGA2	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
ITGA2	taipale_tf_pairs__HOXB2_ELF1_SMGGAAGTMRTTA_CAP	ELF1; HOXB2 (directAnnotation).
ITGA2	metacluster_141.4	GLIS2 (directAnnotation).
ITGA2	metacluster_15.4	SMAD6 (directAnnotation). SMAD6 (inferredBy_Orthology).
ITGA2	metacluster_27.29	ZNF583 (directAnnotation). ZNF583 (inferredBy_Orthology).
ITGA2	taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP	ELK1; FOXI1 (directAnnotation).

Page: 1 2

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."