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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: IQGAP2

Summary for IQGAP2

Gene information	Gene symbol	IQGAP2
	Ensembl ID	ENSG00000145703
	Entrez ID	10788
	Gene name	IQ motif containing GTPase activating protein 2
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q13576

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Dataset with differentially expressed gene: IQGAP2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Mono/Macro	-0.295437	1.05e-04
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	B cells	-0.482862	4.40e-05
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.555187	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.490174	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.519741	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.514125	0.00e+00

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Expression of IQGAP2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to IQGAP2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating IQGAP2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
IQGAP2	hsa-miR-548x-3p	99.1708	NM_001285460
IQGAP2	hsa-miR-548aj-3p	99.1708	NM_001285460
IQGAP2	hsa-miR-4729	99.0806	NM_001285460
IQGAP2	hsa-miR-579-3p	99.0603	NM_001285460
IQGAP2	hsa-miR-664b-3p	99.0603	NM_001285460
IQGAP2	hsa-miR-4760-3p	98.7932	NM_001285460
IQGAP2	hsa-miR-548ah-3p	98.7534	NM_001285460
IQGAP2	hsa-miR-548am-3p	98.7534	NM_001285460
IQGAP2	hsa-miR-548aq-3p	98.7534	NM_001285460
IQGAP2	hsa-miR-548ae-3p	98.7534	NM_001285460
IQGAP2	hsa-miR-548j-3p	98.7534	NM_001285460
IQGAP2	hsa-miR-5696	98.1029	NM_001285460
IQGAP2	hsa-miR-664a-3p	97.1267	NM_001285460
IQGAP2	hsa-miR-5582-5p	96.539	NM_001285460
IQGAP2	hsa-miR-4753-3p	94.9698	NM_001285460
IQGAP2	hsa-miR-1827	94.8728	NM_001285460
IQGAP2	hsa-miR-1185-1-3p	94.5118	NM_001285460
IQGAP2	hsa-let-7f-2-3p	94.5118	NM_001285460
IQGAP2	hsa-miR-1185-2-3p	94.5118	NM_001285460
IQGAP2	hsa-miR-548bb-3p	94.3386	NM_001285460
IQGAP2	hsa-miR-548z	94.3386	NM_001285460
IQGAP2	hsa-miR-548d-3p	94.3386	NM_001285460
IQGAP2	hsa-miR-548ac	94.3386	NM_001285460
IQGAP2	hsa-miR-548h-3p	94.3386	NM_001285460
IQGAP2	hsa-miR-4275	93.9476	NM_001285460
IQGAP2	hsa-miR-363-3p	93.8589	NM_001285460
IQGAP2	hsa-miR-25-3p	93.8589	NM_001285460
IQGAP2	hsa-miR-92a-3p	93.8589	NM_001285460
IQGAP2	hsa-miR-92b-3p	93.8589	NM_001285460
IQGAP2	hsa-miR-32-5p	93.8589	NM_001285460
IQGAP2	hsa-miR-367-3p	93.8589	NM_001285460
IQGAP2	hsa-miR-5692a	93.7878	NM_001285460
IQGAP2	hsa-miR-133a-3p	93.3997	NM_001285460
IQGAP2	hsa-miR-133b	93.3997	NM_001285460
IQGAP2	hsa-miR-524-5p	93.3837	NM_001285460
IQGAP2	hsa-miR-520d-5p	93.3837	NM_001285460
IQGAP2	hsa-miR-548an	93.1369	NM_001285460
IQGAP2	hsa-miR-3671	92.8563	NM_001285460
IQGAP2	hsa-miR-219b-3p	91.6332	NM_001285460
IQGAP2	hsa-miR-607	89.4139	NM_001285460
IQGAP2	hsa-miR-12124	88.6844	NM_001285460
IQGAP2	hsa-miR-4496	88.6844	NM_001285460
IQGAP2	hsa-miR-10522-5p	87.4833	NM_001285460
IQGAP2	hsa-miR-29a-5p	87.3193	NM_001285460
IQGAP2	hsa-miR-335-3p	87.236	NM_001285460
IQGAP2	hsa-miR-4282	86.3972	NM_001285460
IQGAP2	hsa-miR-506-3p	86.3765	NM_001285460
IQGAP2	hsa-miR-124-3p	86.3765	NM_001285460
IQGAP2	hsa-miR-551b-5p	84.7743	NM_001285460
IQGAP2	hsa-miR-589-3p	81.2702	NM_001285460

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Motifs and transcription factors (TFs) regulating IQGAP2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
IQGAP2	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
IQGAP2	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
IQGAP2	kznf__ZNF25_Imbeault2017_OM_MEME	ZNF25 (directAnnotation).
IQGAP2	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
IQGAP2	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
IQGAP2	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).
IQGAP2	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
IQGAP2	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
IQGAP2	metacluster_3.14	WT1; WT1 (directAnnotation).
IQGAP2	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
IQGAP2	cisbp__M07938	E2F1 (directAnnotation).
IQGAP2	metacluster_107.2	CERS2; CERS3; CERS4; CERS5; CERS6 (inferredBy_Orthology).
IQGAP2	metacluster_107.1	CERS2; CERS3; CERS4; CERS5; CERS6 (inferredBy_Orthology).
IQGAP2	metacluster_141.13	METTL14 (inferredBy_Orthology).
IQGAP2	metacluster_119.2	CCNT2; GATA1; GATA1; GATA1; GATA1; GATA2; GATA2; GATA2; NCOA1; TAL1; TAL1; TAL1; TAL1; ZNF823 (directAnnotation). GATA1; TAL1; TAL1; TAL1; TAL1 (inferredBy_Orthology).
IQGAP2	transfac_pro__M05521	ZNF398 (directAnnotation).
IQGAP2	taipale_cyt_meth__LBX2_CTCGTTAN_eDBD	LBX2 (directAnnotation).
IQGAP2	metacluster_168.18	ZNF214; ZNF239; ZNF45; ZNF696 (directAnnotation).
IQGAP2	metacluster_159.4	INSM1; INSM1; INSM1 (directAnnotation).
IQGAP2	transfac_pro__M05539	OSR2 (inferredBy_Orthology).
IQGAP2	taipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAP	ELK3; HOXB2 (directAnnotation).
IQGAP2	kznf__ZNF792_Imbeault2017_OM_MEME	ZNF792 (directAnnotation).
IQGAP2	dbtfbs__ZFP91_K562_ENCSR898XMH_merged_N1	ZFP91 (directAnnotation).
IQGAP2	taipale_tf_pairs__GCM1_FOXO1_RTMAATAMGGGYRN_CAP	FOXO1; GCM1 (directAnnotation).
IQGAP2	metacluster_135.11	NR2C2 (directAnnotation).
IQGAP2	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
IQGAP2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
IQGAP2	metacluster_7.13	ZFX (directAnnotation).
IQGAP2	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
IQGAP2	cisbp__M00968	MTF2 (directAnnotation).
IQGAP2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
IQGAP2	metacluster_198.3	ZFP64 (directAnnotation).
IQGAP2	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
IQGAP2	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
IQGAP2	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
IQGAP2	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
IQGAP2	cisbp__M00788	ZFY (inferredBy_Orthology).
IQGAP2	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
IQGAP2	metacluster_175.1	ZNF283 (directAnnotation).
IQGAP2	hdpi__ZNF304	ZNF304 (directAnnotation).
IQGAP2	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
IQGAP2	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
IQGAP2	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
IQGAP2	transfac_pro__M01199	TRIM28 (directAnnotation).
IQGAP2	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
IQGAP2	metacluster_151.2	ZNF23 (directAnnotation).
IQGAP2	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
IQGAP2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
IQGAP2	transfac_pro__M03806	ZBTB7C (directAnnotation).
IQGAP2	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."