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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: IPO7

Summary for IPO7

Gene information	Gene symbol	IPO7
	Ensembl ID	ENSG00000205339
	Entrez ID	10527
	Gene name	importin 7
	Synonyms	Imp7\|RANBP7
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: IPO7

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-1.19221	2.49e-04
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.34398	2.61e-18
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	-0.30765	6.38e-05
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.350659	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.510046	6.79e-40
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.772129	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.348501	0.00e+00

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Expression of IPO7 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to IPO7

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating IPO7

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
IPO7	hsa-miR-153-5p	99.8747	NM_006391
IPO7	hsa-miR-5696	99.2655	NM_006391
IPO7	hsa-miR-4760-3p	98.6283	NM_006391
IPO7	hsa-miR-16-5p	98.4962	NM_006391
IPO7	hsa-miR-195-5p	98.4962	NM_006391
IPO7	hsa-miR-15b-5p	98.2714	NM_006391
IPO7	hsa-miR-15a-5p	98.2714	NM_006391
IPO7	hsa-miR-4524b-5p	97.9233	NM_006391
IPO7	hsa-miR-4524a-5p	97.9233	NM_006391
IPO7	hsa-miR-4666a-5p	97.7765	NM_006391
IPO7	hsa-miR-424-5p	97.5771	NM_006391
IPO7	hsa-miR-6838-5p	97.5771	NM_006391
IPO7	hsa-miR-497-5p	97.5771	NM_006391
IPO7	hsa-miR-448	97.5279	NM_006391
IPO7	hsa-miR-664b-3p	96.8517	NM_006391
IPO7	hsa-miR-579-3p	96.8517	NM_006391
IPO7	hsa-miR-455-5p	96.1448	NM_006391
IPO7	hsa-miR-3613-3p	94.4002	NM_006391
IPO7	hsa-miR-200b-3p	93.6521	NM_006391
IPO7	hsa-miR-429	93.6521	NM_006391
IPO7	hsa-miR-200c-3p	93.6521	NM_006391
IPO7	hsa-miR-214-3p	93.5913	NM_006391
IPO7	hsa-miR-3619-5p	93.5913	NM_006391
IPO7	hsa-miR-761	93.5913	NM_006391
IPO7	hsa-miR-4473	93.356	NM_006391
IPO7	hsa-miR-4460	92.0833	NM_006391
IPO7	hsa-miR-1825	91.7939	NM_006391
IPO7	hsa-miR-142-3p	90.6137	NM_006391
IPO7	hsa-miR-1252-3p	90.5172	NM_006391
IPO7	hsa-miR-1250-3p	90.1371	NM_006391
IPO7	hsa-miR-140-5p	89.5912	NM_006391
IPO7	hsa-miR-5004-3p	89.362	NM_006391
IPO7	hsa-miR-664a-3p	89.1862	NM_006391
IPO7	hsa-miR-1236-3p	88.9366	NM_006391
IPO7	hsa-miR-1297	88.9093	NM_006391
IPO7	hsa-miR-6795-3p	88.5834	NM_006391
IPO7	hsa-miR-503-5p	88.4711	NM_006391
IPO7	hsa-miR-4729	88.3796	NM_006391
IPO7	hsa-miR-4262	88.0984	NM_006391
IPO7	hsa-miR-4524a-3p	87.8988	NM_006391
IPO7	hsa-miR-6887-3p	87.7507	NM_006391
IPO7	hsa-miR-6852-5p	87.1103	NM_006391
IPO7	hsa-miR-340-5p	87.0553	NM_006391
IPO7	hsa-miR-6073	86.9267	NM_006391
IPO7	hsa-miR-3658	86.858	NM_006391
IPO7	hsa-miR-6826-3p	86.8536	NM_006391
IPO7	hsa-miR-7852-3p	86.5903	NM_006391
IPO7	hsa-miR-646	85.5142	NM_006391
IPO7	hsa-miR-3617-5p	85.1226	NM_006391
IPO7	hsa-miR-641	85.1226	NM_006391

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Motifs and transcription factors (TFs) regulating IPO7

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
IPO7	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
IPO7	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
IPO7	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).
IPO7	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
IPO7	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
IPO7	metacluster_3.14	WT1; WT1 (directAnnotation).
IPO7	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
IPO7	cisbp__M07938	E2F1 (directAnnotation).
IPO7	metacluster_34.4	ETS1; ETS1; ETS1; HCFC1; SIX5; SIX5; SIX5; SIX5; SMARCC2; SMARCC2; THAP11; THAP11; ZNF143; ZNF143; ZNF143; ZNF143 (directAnnotation). TBX2; THAP11; THAP11; ZNF143 (inferredBy_Orthology).
IPO7	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
IPO7	transfac_pro__M00652	NRF1 (directAnnotation).
IPO7	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
IPO7	taipale_tf_pairs__ETV2_HES7_NNCACGTGNNNNNCGGAWRY_CAP_repr	ETV2; HES7 (directAnnotation).
IPO7	taipale_tf_pairs__TFAP2C_MAX_TNSCCNNNGGSNNNCACGTGN_CAP_repr	MAX; TFAP2C (directAnnotation).
IPO7	metacluster_135.11	NR2C2 (directAnnotation).
IPO7	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
IPO7	tfdimers__MD00038	TFAP2C (directAnnotation).
IPO7	metacluster_7.13	ZFX (directAnnotation).
IPO7	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
IPO7	cisbp__M00968	MTF2 (directAnnotation).
IPO7	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
IPO7	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
IPO7	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
IPO7	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
IPO7	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
IPO7	cisbp__M00788	ZFY (inferredBy_Orthology).
IPO7	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
IPO7	metacluster_175.1	ZNF283 (directAnnotation).
IPO7	hdpi__ZNF304	ZNF304 (directAnnotation).
IPO7	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
IPO7	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
IPO7	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
IPO7	transfac_pro__M01199	TRIM28 (directAnnotation).
IPO7	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
IPO7	metacluster_151.2	ZNF23 (directAnnotation).
IPO7	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
IPO7	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
IPO7	transfac_pro__M03806	ZBTB7C (directAnnotation).
IPO7	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
IPO7	kznf__KLF1_Barrera2016.2_PBM	KLF1 (directAnnotation).
IPO7	transfac_pro__M01253	CNOT3 (directAnnotation).
IPO7	taipale_tf_pairs__E2F3_HES7_NNNNGCGCSNNNNNCACGTGNN_CAP	E2F3; HES7 (directAnnotation).
IPO7	transfac_pro__M02089	E2F3 (directAnnotation).
IPO7	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
IPO7	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
IPO7	tfdimers__MD00483	ZBTB14 (directAnnotation).
IPO7	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
IPO7	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
IPO7	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
IPO7	taipale_tf_pairs__TEAD4_SPIB_RGAATGCGGAAGTN_CAP_1	SPIB; TEAD4 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."