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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: HNRNPH1

Summary for HNRNPH1

Gene information	Gene symbol	HNRNPH1
	Ensembl ID	ENSG00000284254
	Entrez ID	3187
	Gene name	heterogeneous nuclear ribonucleoprotein H1
	Synonyms	hnRNPH\|HNRPH1
	Gene type	protein_coding
	UniProtAcc	P31943

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Dataset with differentially expressed gene: HNRNPH1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Erythrocytes	-0.572072	1.45e-30
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	-0.255237	1.23e-03
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	B cells	-0.304475	1.69e-03
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	CD8+ T cells	-0.538868	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	cDCs	-0.536955	3.90e-03
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Mono/Macro	-0.258106	5.21e-28
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Erythrocytes	-0.542465	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.604262	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.561547	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.337781	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.339574	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.59244	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Erythrocytes	0.601077	4.83e-17
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	NK cells	0.387645	1.21e-03
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	CD4+ T cells	0.332034	1.64e-04
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	post	CD8+ T cells	-0.25321	3.27e-11
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.292903	1.60e-26
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	0.668415	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Mono/Macro	0.295733	3.26e-11
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	B cells	0.485761	4.26e-15
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	CD8+ T cells	0.489693	1.04e-26
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.622029	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	0.519111	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	0.293902	0.00e+00

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Expression of HNRNPH1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to HNRNPH1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating HNRNPH1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
HNRNPH1	hsa-miR-302c-5p	96.3542	NM_001257293
HNRNPH1	hsa-miR-10395-3p	95.243	NM_001257293
HNRNPH1	hsa-miR-10523-5p	93.9846	NM_001257293
HNRNPH1	hsa-miR-132-3p	93.2608	NM_001257293
HNRNPH1	hsa-miR-212-3p	93.2608	NM_001257293
HNRNPH1	hsa-miR-3613-3p	93.1823	NM_001257293
HNRNPH1	hsa-miR-3173-3p	92.9671	NM_001257293
HNRNPH1	hsa-miR-6891-5p	92.9671	NM_001257293
HNRNPH1	hsa-miR-12118	92.9671	NM_001257293
HNRNPH1	hsa-miR-4436b-5p	91.5005	NM_001257293
HNRNPH1	hsa-miR-3922-5p	90.2777	NM_001257293
HNRNPH1	hsa-miR-4772-5p	87.1175	NM_001257293
HNRNPH1	hsa-miR-124-5p	86.6898	NM_001257293
HNRNPH1	hsa-miR-4275	86.4943	NM_001257293
HNRNPH1	hsa-miR-4803	85.5608	NM_001257293
HNRNPH1	hsa-miR-3144-3p	83.6529	NM_001257293
HNRNPH1	hsa-miR-5702	83.6125	NM_001257293
HNRNPH1	hsa-miR-4697-3p	83.563	NM_001257293
HNRNPH1	hsa-miR-4738-3p	83.4051	NM_001257293
HNRNPH1	hsa-miR-548g-3p	81.8058	NM_001257293
HNRNPH1	hsa-miR-6736-3p	81.7576	NM_001257293
HNRNPH1	hsa-miR-496	81.0899	NM_001257293
HNRNPH1	hsa-miR-524-5p	80.9126	NM_001257293
HNRNPH1	hsa-miR-520d-5p	80.9126	NM_001257293

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Motifs and transcription factors (TFs) regulating HNRNPH1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
HNRNPH1	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
HNRNPH1	taipale_tf_pairs__TEAD4_DLX2_NRCATTCNNNNYAATTN_CAP_repr	DLX2; TEAD4 (directAnnotation).
HNRNPH1	metacluster_159.8	ZNF770 (directAnnotation). ZNF770 (inferredBy_Orthology).
HNRNPH1	metacluster_9.38	DLX2 (directAnnotation).
HNRNPH1	metacluster_71.5	HIF1A (directAnnotation).
HNRNPH1	tfdimers__MD00463	CHURC1; DBP (directAnnotation).
HNRNPH1	taipale_tf_pairs__GCM1_SOX2_RTRSGGGNNNATTGTKY_CAP_repr	GCM1; SOX2 (directAnnotation).
HNRNPH1	kznf__ZNF605_Imbeault2017_OM_RCADE	ZNF605 (directAnnotation).
HNRNPH1	transfac_pro__M04856	BATF (directAnnotation).
HNRNPH1	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
HNRNPH1	taipale_tf_pairs__ETV2_TEF_RSCGGAWNTTRCGYAAN_CAP	ETV2; TEF (directAnnotation).
HNRNPH1	transfac_pro__M06727	PRDM6 (directAnnotation).
HNRNPH1	taipale_tf_pairs__ETV5_CEBPD_NSCGGANNTTRCGYAAN_CAP	CEBPD; ETV5 (directAnnotation).
HNRNPH1	kznf__ZNF354B_Imbeault2017_RP_RCADE	ZNF354B (directAnnotation).
HNRNPH1	transfac_pro__M06075	ZNF197 (directAnnotation).
HNRNPH1	bergman__pho	YY1 (inferredBy_Orthology).
HNRNPH1	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
HNRNPH1	taipale_tf_pairs__ETV2_CEBPD_RSCGGANNTTGCGYAAN_CAP_repr	CEBPD; ETV2 (directAnnotation).
HNRNPH1	transfac_pro__M05854	ZNF619 (directAnnotation).
HNRNPH1	taipale_tf_pairs__MYBL1_ONECUT2_NAACGGNNATYGANN_CAP_repr	MYBL1; ONECUT2 (directAnnotation).
HNRNPH1	taipale_tf_pairs__PITX1_EOMES_GGATTANNARGTGTKN_CAP_repr	EOMES; PITX1 (directAnnotation).
HNRNPH1	transfac_pro__M06259	ZNF91 (directAnnotation).
HNRNPH1	metacluster_74.19	HNF1A (inferredBy_Orthology).
HNRNPH1	taipale_cyt_meth__JUND_NRTGACGCATN_eDBD_repr	JUND (directAnnotation).
HNRNPH1	tfdimers__MD00207	HOXA13; PDX1 (directAnnotation).
HNRNPH1	transfac_pro__M06346	E4F1 (directAnnotation).
HNRNPH1	transfac_pro__M05577	ZNF579 (inferredBy_Orthology).
HNRNPH1	metacluster_9.42	LHX3 (inferredBy_Orthology).
HNRNPH1	metacluster_51.11	NOTO (directAnnotation).
HNRNPH1	metacluster_51.19	HOXD4 (directAnnotation).
HNRNPH1	metacluster_139.9	TFE3 (inferredBy_Orthology).
HNRNPH1	metacluster_41.42	NKX3-1 (directAnnotation).
HNRNPH1	metacluster_9.43	LHX1 (inferredBy_Orthology).
HNRNPH1	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
HNRNPH1	taipale__YY2_DBD_NNCCGCCATNW_repr	YY2 (directAnnotation).
HNRNPH1	metacluster_141.4	GLIS2 (directAnnotation).
HNRNPH1	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
HNRNPH1	jaspar__MA0748.2	YY2 (directAnnotation).
HNRNPH1	transfac_pro__M00652	NRF1 (directAnnotation).
HNRNPH1	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
HNRNPH1	transfac_pro__M04950	EGR1 (directAnnotation).
HNRNPH1	swissregulon__hs__GMEB2	GMEB2 (directAnnotation).
HNRNPH1	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
HNRNPH1	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
HNRNPH1	metacluster_19.6	GMEB1 (directAnnotation). GMEB1 (inferredBy_Orthology).
HNRNPH1	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
HNRNPH1	transfac_public__M00024	E2F1 (directAnnotation).
HNRNPH1	taipale_tf_pairs__ETV2_SOX15_RSCGGAANNNNNNNYWTTGT_CAP_repr	ETV2; SOX15 (directAnnotation).
HNRNPH1	jaspar__MA1105.2	GRHL2 (directAnnotation).
HNRNPH1	transfac_pro__M05519	FEZF2 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
HNRNPH1	"Copper"	DB09130	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."