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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: HMGN3

Summary for HMGN3

Gene information	Gene symbol	HMGN3
	Ensembl ID	ENSG00000118418
	Entrez ID	9324
	Gene name	high mobility group nucleosomal binding domain 3
	Synonyms	TRIP7
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: HMGN3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.573612	0.00e+00
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	0.276144	3.71e-31
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.276066	1.03e-02
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.289859	2.25e-08
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Malignant cells	-0.284201	3.57e-07
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	0.280957	4.00e-11
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-2.50902	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.774625	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.581434	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	0.35722	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.315914	5.20e-17
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.350247	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Malignant cells	-0.441875	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	-0.480928	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.628866	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	0.495458	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	0.476908	0.00e+00

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Expression of HMGN3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to HMGN3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating HMGN3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
HMGN3	hsa-miR-137-3p	98.7335	NM_001318887
HMGN3	hsa-miR-6835-3p	96.7148	NM_001201362
HMGN3	hsa-miR-3605-5p	96.5458	NM_001201363
HMGN3	hsa-miR-208b-5p	96.3915	NM_001201363
HMGN3	hsa-miR-208a-5p	96.3915	NM_001201363
HMGN3	hsa-miR-497-3p	95.7274	NM_001318887
HMGN3	hsa-miR-6811-3p	94.3186	NM_001201362
HMGN3	hsa-miR-498-3p	93.847	NM_001201362
HMGN3	hsa-miR-890	91.768	NM_001201363
HMGN3	hsa-miR-6889-3p	91.6369	NM_001201362
HMGN3	hsa-miR-1913	91.4214	NM_001201362
HMGN3	hsa-miR-4433b-5p	91.2943	NM_001201363
HMGN3	hsa-miR-6529-3p	90.6148	NM_001201362
HMGN3	hsa-miR-6893-5p	90.5401	NM_001201362
HMGN3	hsa-miR-940	90.5401	NM_001201362
HMGN3	hsa-miR-6808-5p	90.5401	NM_001201362
HMGN3	hsa-miR-4716-5p	90.5236	NM_001201363
HMGN3	hsa-miR-10525-3p	90.1745	NM_001201363
HMGN3	hsa-miR-6502-5p	89.8238	NM_001201363
HMGN3	hsa-miR-1301-5p	89.8238	NM_001201363
HMGN3	hsa-miR-580-5p	89.2961	NM_001318887
HMGN3	hsa-miR-12126	89.2616	NM_001201363
HMGN3	hsa-miR-7151-3p	87.9103	NM_001201362
HMGN3	hsa-miR-3145-3p	87.6637	NM_001201363
HMGN3	hsa-miR-4742-5p	87.4635	NM_001201362
HMGN3	hsa-miR-2115-5p	86.3768	NM_001201363
HMGN3	hsa-miR-3619-5p	84.7188	NM_001201362
HMGN3	hsa-miR-6508-5p	84.3637	NM_001201363
HMGN3	hsa-miR-6776-3p	81.6673	NM_001318887
HMGN3	hsa-miR-3158-5p	81.4304	NM_001201363
HMGN3	hsa-miR-548av-3p	80.9466	NM_001201363
HMGN3	hsa-miR-761	80.7803	NM_001201362
HMGN3	hsa-miR-214-3p	80.7803	NM_001201362

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Motifs and transcription factors (TFs) regulating HMGN3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
HMGN3	hdpi__ETV4	ETV4 (directAnnotation).
HMGN3	cisbp__M02645	ETS1 (directAnnotation).
HMGN3	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
HMGN3	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
HMGN3	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
HMGN3	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
HMGN3	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
HMGN3	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
HMGN3	transfac_pro__M04826	EP300 (directAnnotation).
HMGN3	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
HMGN3	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
HMGN3	jaspar__MA1122.1	TFDP1 (directAnnotation).
HMGN3	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
HMGN3	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
HMGN3	transfac_pro__M01783	SP2 (directAnnotation).
HMGN3	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
HMGN3	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
HMGN3	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
HMGN3	metacluster_7.13	ZFX (directAnnotation).
HMGN3	jaspar__MA0748.2	YY2 (directAnnotation).
HMGN3	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
HMGN3	taipale_tf_pairs__ATF4_CEBPD_NGATGATGCAATNN_CAP	ATF4; CEBPD (directAnnotation).
HMGN3	metacluster_2.8	IRF4; IRF5; IRF6; IRF9 (directAnnotation). IRF3; IRF5; IRF5; IRF6 (inferredBy_Orthology).
HMGN3	metacluster_161.2	LHX8 (directAnnotation).
HMGN3	metacluster_112.5	HOXA4; PAX3; PAX7; PAX7 (directAnnotation).
HMGN3	transfac_pro__M05513	ZNF641 (inferredBy_Orthology).
HMGN3	swissregulon__hs__DMC1	DMC1 (directAnnotation).
HMGN3	taipale_tf_pairs__ETV2_SPDEF_NSCGGACGGAWATCCGSNT_CAP	ETV2; SPDEF (directAnnotation).
HMGN3	taipale_tf_pairs__ERF_DLX3_RSCGGAANNNNYAATTA_CAP_repr	DLX3; ERF (directAnnotation).
HMGN3	metacluster_2.7	IRF1; IRF1; IRF2; IRF2; IRF3; IRF4; IRF5; IRF6; IRF7; IRF7; IRF8; IRF8; IRF9; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; STAT1; STAT1; STAT2 (directAnnotation). PRDM1; PRDM1; PRDM1 (inferredBy_Orthology).
HMGN3	transfac_pro__M05860	ZNF548 (directAnnotation).
HMGN3	kznf__ZNF25_Imbeault2017_OM_MEME	ZNF25 (directAnnotation).
HMGN3	transfac_pro__M05798	ZNF517 (directAnnotation).
HMGN3	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).
HMGN3	transfac_pro__M07436	WT1 (directAnnotation).
HMGN3	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
HMGN3	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
HMGN3	transfac_pro__M02089	E2F3 (directAnnotation).
HMGN3	transfac_pro__M01122	ZNF219 (directAnnotation).
HMGN3	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
HMGN3	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
HMGN3	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
HMGN3	transfac_pro__M08819	KLF2 (directAnnotation).
HMGN3	transfac_pro__M01175	ZBTB7B (directAnnotation).
HMGN3	transfac_pro__M01118	WT1 (directAnnotation).
HMGN3	swissregulon__hs__KLF6	KLF6 (directAnnotation).
HMGN3	transfac_pro__M01303	SP1 (directAnnotation).
HMGN3	transfac_pro__M04595	SALL2 (directAnnotation).
HMGN3	transfac_pro__M00716	ZBTB14 (directAnnotation).
HMGN3	metacluster_133.2	CPSF4; CPSF4; E2F4; FOXO3; KLF13; KLF15; KLF17; KLF5; MAZ; MAZ; MAZ; MZF1; PATZ1; PATZ1; PATZ1; PATZ1; PLAG1; PRDM9; SP4; VEZF1; WT1; ZBTB17; ZBTB7A; ZBTB7A; ZBTB7B; ZNF148; ZNF148; ZNF148; ZNF148; ZNF180; ZNF180; ZNF202; ZNF219; ZNF219; ZNF263; ZNF263; ZNF28; ZNF281; ZNF281; ZNF281; ZNF281; ZNF281; ZNF383; ZNF398; ZNF398; ZNF444; ZNF444; ZNF467; ZNF543; ZNF543; ZNF641; ZNF692; ZNF737; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF880; ZNF880 (directAnnotation). MAZ; PLAG1; PLAGL1; SP1; SP5; SP5; ZBTB17; ZNF281; ZNF281; ZNF281; ZNF641; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."