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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: GSN

Summary for GSN

Gene information	Gene symbol	GSN
	Ensembl ID	ENSG00000148180
	Entrez ID	2934
	Gene name	gelsolin
	Synonyms	DKFZp313L0718
	Gene type	protein_coding
	UniProtAcc	P06396

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Dataset with differentially expressed gene: GSN

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.6156	8.43e-09
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.65913	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	cDCs	0.642222	1.47e-20
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	cDCs	0.807961	4.35e-13
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Mono/Macro	0.311711	3.44e-04
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.361565	1.80e-18
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	cDCs	0.437273	1.25e-10
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.402239	2.51e-12
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	NK cells	-0.355334	1.61e-12
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.451102	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.414385	4.25e-24
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.459594	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.815881	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.267467	0.00e+00

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Expression of GSN in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to GSN

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating GSN

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
GSN	hsa-miR-8485	92.1721	NM_001127664
GSN	hsa-miR-4698	87.113	NM_001127664
GSN	hsa-miR-124-3p	86.3653	NM_000177
GSN	hsa-miR-450b-5p	84.4529	NM_000177
GSN	hsa-miR-200a-3p	82.0913	NM_000177
GSN	hsa-miR-141-3p	82.0913	NM_000177
GSN	hsa-miR-4307	81.3583	NM_000177
GSN	hsa-miR-506-3p	81.3316	NM_000177

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Motifs and transcription factors (TFs) regulating GSN

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
GSN	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
GSN	jaspar__MA1561.1	SOX12 (directAnnotation).
GSN	taipale__ELK1_full_NACTTCCGSCGGAARMN_repr	ELK1 (directAnnotation).
GSN	jaspar__MA1562.1	SOX14 (directAnnotation).
GSN	taipale_tf_pairs__HOXD12_ETV4_RSCGGAAGTCGTAAAN_CAP	ETV4; HOXD12 (directAnnotation).
GSN	jaspar__MA1932.1	HOXB13 (directAnnotation).
GSN	transfac_pro__M06672	ZNF442 (directAnnotation).
GSN	taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP	ETV4; GCM1 (directAnnotation).
GSN	taipale_tf_pairs__SOX17_ACCGAACAAT_HT	SOX17 (directAnnotation).
GSN	metacluster_198.3	ZFP64 (directAnnotation).
GSN	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
GSN	metacluster_156.2	ATF3; ATF4; ATF4; ATF4; ATF4; ATF4; ATF4; CEBPG; CEBPG; DDIT3; MYC (directAnnotation). ATF4; ATF4; ATF4; CEBPG; DDIT3 (inferredBy_Orthology).
GSN	taipale_tf_pairs__ATF4_CEBPD_NGATGATGCAATNN_CAP	ATF4; CEBPD (directAnnotation).
GSN	hdpi__FLI1	FLI1 (directAnnotation).
GSN	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
GSN	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
GSN	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
GSN	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
GSN	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
GSN	cisbp__M08198	ELF1 (directAnnotation).
GSN	transfac_pro__M04950	EGR1 (directAnnotation).
GSN	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP	ERG; TEAD4 (directAnnotation).
GSN	taipale_tf_pairs__HOXB2_ETV1_ACCGGAAATGA_CAP	ETV1; HOXB2 (directAnnotation).
GSN	taipale_tf_pairs__ERF_TBX21_TMACACCGGAAG_CAP	ERF; TBX21 (directAnnotation).
GSN	kznf__KLF1_Barrera2016.2_PBM	KLF1 (directAnnotation).
GSN	swissregulon__hs__ELF2	ELF2 (directAnnotation).
GSN	taipale_tf_pairs__ETV5_EVX1_RSCGGWAATKR_CAP	ETV5; EVX1 (directAnnotation).
GSN	metacluster_161.4	LHX9 (directAnnotation).
GSN	metacluster_157.2	ATF3; ATF3; ATF3; BACH1; BACH1; BACH1; BACH2; BACH2; BACH2; BACH2; BATF; BATF; BCL11A; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JDP2; JDP2; JDP2; JDP2; JDP2; JDP2; JDP2; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; JUND; JUND; JUND; JUND; MAF; MAFB; MAFF; MAFG; MAFK; NFE2; NFE2; NFE2; NFE2; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2; NFE2L3; ZNF3; ZSCAN5C (directAnnotation). FOSL1; JUN; JUN; JUN; JUNB; JUNB; JUND (inferredBy_Orthology).
GSN	taipale_tf_pairs__ELK1_FOXI1_RSCGGAANRTMAAYA_CAP_repr	ELK1; FOXI1 (directAnnotation).
GSN	transfac_pro__M05769	ZNF48 (inferredBy_Orthology).
GSN	metacluster_22.19	NFE2 (directAnnotation).
GSN	swissregulon__hs__ZKSCAN3	ZKSCAN3 (directAnnotation).
GSN	hocomoco__FOXP1_HUMAN.H11MO.0.A	FOXP1 (directAnnotation).
GSN	metacluster_22.18	BACH2 (inferredBy_Orthology).
GSN	metacluster_137.2	ATF3; BACH2; BATF; BATF; BATF; BATF; BATF3; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSB; FOSB; FOSB; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; INSM2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; SMARCC1 (directAnnotation). ATF3; ATF3; BATF; FOS; FOSB; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUND; JUND; JUND; JUND (inferredBy_Orthology).
GSN	transfac_pro__M05358	RLF (directAnnotation).
GSN	metacluster_167.5	EHF; ELF5; NFATC3; SPI1; SPI1; SPI1; SPI1; SPI1; SPI1; SPI1; SPI1; SPI1; SPI1; SPI1; SPIB; SPIB; SPIB; SPIB; SPIB; SPIB; SPIB; SPIB; SPIB; SPIB; SPIC; SPIC; STAT5A (directAnnotation). ETS1; SPI1; SPI1; SPI1; SPI1; SPI1; SPI1; SPIB; SPIC (inferredBy_Orthology).
GSN	tfdimers__MD00495	LEF1; TCF7; TCF7L1 (directAnnotation).
GSN	metacluster_59.1	HOXA9; HOXA9; HOXA9; HOXB6; HOXB7; HOXB7; HOXB8; HOXB8; HOXC6; HOXC8; HOXC8; MEIS1; MEIS1; MEIS2; MEIS2; PBX1; PBX1; PBX1; PBX2; PBX2 (directAnnotation). HOXA9; HOXA9; HOXB4; HOXB6; HOXC6; HOXC9; HOXC9; LEF1; PDX1; PDX1; TCF7L2 (inferredBy_Orthology).
GSN	tfdimers__MD00554	CUX1; EP300 (directAnnotation).
GSN	hocomoco__FOXJ3_HUMAN.H11MO.1.B	FOXJ3 (directAnnotation).
GSN	metacluster_70.16	POU5F1; POU5F1 (directAnnotation).
GSN	tfdimers__MD00014	ARID3A; KLF4 (directAnnotation).
GSN	metacluster_82.5	ZKSCAN8; ZNF205; ZNF227; ZNF594 (directAnnotation).
GSN	metacluster_150.4	SKOR1; SKOR1; SKOR2; SKOR2 (directAnnotation).
GSN	metacluster_22.37	BACH1 (directAnnotation).
GSN	metacluster_22.34	BACH2 (directAnnotation).
GSN	transfac_pro__M05542	SNAPC4 (directAnnotation).
GSN	metacluster_22.13	MAFK (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
GSN	"Copper"	DB09130	small molecule
GSN	"Latrunculin A"	DB02621	small molecule
GSN	"Zinc acetate"	DB14487	small molecule
GSN	"Zinc"	DB01593	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."