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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: GPBP1

Summary for GPBP1

Gene information	Gene symbol	GPBP1
	Ensembl ID	ENSG00000062194
	Entrez ID	65056
	Gene name	GC-rich promoter binding protein 1
	Synonyms	DKFZp761C169
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: GPBP1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.293112	1.16e-21
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.308515	4.55e-05
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.416737	3.34e-42
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	-0.408214	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.36607	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.305635	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.252107	1.28e-22
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	B cells	-0.718578	9.27e-03
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	0.266295	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.475902	1.65e-15

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Expression of GPBP1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to GPBP1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating GPBP1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
GPBP1	hsa-miR-5696	98.7182	NM_022913
GPBP1	hsa-miR-320c	98.1113	NM_001203246
GPBP1	hsa-miR-4429	98.1113	NM_001203246
GPBP1	hsa-miR-320b	98.1113	NM_001203246
GPBP1	hsa-miR-320a-3p	98.1113	NM_001203246
GPBP1	hsa-miR-320d	98.1113	NM_001203246
GPBP1	hsa-miR-3529-3p	97.9136	NM_022913
GPBP1	hsa-miR-8086	97.2062	NM_022913
GPBP1	hsa-miR-4766-5p	96.9122	NM_001203246
GPBP1	hsa-miR-10527-5p	96.404	NM_001203246
GPBP1	hsa-miR-9-3p	95.9524	NM_001203246
GPBP1	hsa-miR-6802-3p	94.9324	NM_001203246
GPBP1	hsa-miR-548p	94.4737	NM_022913
GPBP1	hsa-miR-4504	93.7781	NM_022913
GPBP1	hsa-miR-524-5p	93.5364	NM_022913
GPBP1	hsa-miR-520d-5p	93.5364	NM_022913
GPBP1	hsa-miR-4262	93.0707	NM_022913
GPBP1	hsa-miR-587	92.9701	NM_001203246
GPBP1	hsa-miR-877-3p	92.8157	NM_001203246
GPBP1	hsa-miR-543	92.3998	NM_022913
GPBP1	hsa-miR-4744	92.2305	NM_001203246
GPBP1	hsa-miR-1276	91.1512	NM_001203246
GPBP1	hsa-miR-4795-3p	91.0729	NM_022913
GPBP1	hsa-miR-181b-5p	90.4221	NM_022913
GPBP1	hsa-miR-181d-5p	90.4221	NM_022913
GPBP1	hsa-miR-181a-5p	90.4221	NM_022913
GPBP1	hsa-miR-181c-5p	90.4221	NM_022913
GPBP1	hsa-miR-133a-5p	89.5961	NM_022913
GPBP1	hsa-miR-664b-3p	89.5627	NM_022913
GPBP1	hsa-miR-579-3p	89.5627	NM_022913
GPBP1	hsa-miR-3613-3p	89.0689	NM_022913
GPBP1	hsa-miR-155-3p	89.0585	NM_001203246
GPBP1	hsa-miR-449c-3p	88.9976	NM_022913
GPBP1	hsa-miR-3065-5p	87.5041	NM_022913
GPBP1	hsa-miR-1252-3p	86.9439	NM_022913
GPBP1	hsa-miR-4729	86.6937	NM_022913
GPBP1	hsa-miR-3685	86.1701	NM_001203246
GPBP1	hsa-miR-126-5p	86.0218	NM_022913
GPBP1	hsa-miR-5685	85.4125	NM_022913
GPBP1	hsa-miR-4690-3p	85.4125	NM_022913
GPBP1	hsa-miR-6719-3p	85.3955	NM_001203246
GPBP1	hsa-miR-2276-3p	84.8355	NM_001203246
GPBP1	hsa-miR-5584-3p	84.6529	NM_022913
GPBP1	hsa-miR-222-3p	84.4797	NM_001203246
GPBP1	hsa-miR-221-3p	84.4797	NM_001203246
GPBP1	hsa-miR-4671-3p	84.1528	NM_001203246
GPBP1	hsa-miR-4712-3p	83.638	NM_022913
GPBP1	hsa-miR-627-3p	83.3232	NM_022913
GPBP1	hsa-miR-4672	82.8229	NM_022913
GPBP1	hsa-miR-374a-3p	82.3412	NM_001203246

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Motifs and transcription factors (TFs) regulating GPBP1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
GPBP1	transfac_public__M00039	CREB1 (directAnnotation).
GPBP1	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
GPBP1	cisbp__M04023	CREB1 (directAnnotation).
GPBP1	transfac_pro__M00691	ATF1 (directAnnotation).
GPBP1	jaspar__MA0039.4	KLF4 (directAnnotation).
GPBP1	transfac_pro__M04746	E2F1 (directAnnotation).
GPBP1	metacluster_163.1	KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF10; KLF10; KLF12; KLF12; KLF12; KLF13; KLF16; KLF17; KLF2; KLF3; KLF3; KLF3; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF5; KLF6; KLF6; KLF6; KLF7; KLF9; KLF9; SALL4; SP1; ZNF148; ZNF148; ZNF526 (directAnnotation). EGR4; KLF1; KLF1; KLF12; KLF12; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF8; KLF9; SP4; SP5; SP5; SP6; SP7; SP8; SP9; ZNF526 (inferredBy_Orthology).
GPBP1	tfdimers__MD00457	SREBF1; SREBF2; ZNF354C (directAnnotation).
GPBP1	transfac_pro__M04595	SALL2 (directAnnotation).
GPBP1	jaspar__MA1117.1	RELB (directAnnotation).
GPBP1	transfac_pro__M08803	CREM (directAnnotation).
GPBP1	metacluster_135.11	NR2C2 (directAnnotation).
GPBP1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
GPBP1	tfdimers__MD00038	TFAP2C (directAnnotation).
GPBP1	metacluster_7.13	ZFX (directAnnotation).
GPBP1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
GPBP1	cisbp__M00968	MTF2 (directAnnotation).
GPBP1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
GPBP1	metacluster_160.20	JUND; PRDM15 (directAnnotation).
GPBP1	cisbp__M00341	PAX6 (directAnnotation).
GPBP1	metacluster_198.3	ZFP64 (directAnnotation).
GPBP1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
GPBP1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
GPBP1	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
GPBP1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
GPBP1	cisbp__M00788	ZFY (inferredBy_Orthology).
GPBP1	metacluster_175.1	ZNF283 (directAnnotation).
GPBP1	hdpi__ZNF304	ZNF304 (directAnnotation).
GPBP1	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
GPBP1	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
GPBP1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
GPBP1	transfac_pro__M01199	TRIM28 (directAnnotation).
GPBP1	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
GPBP1	metacluster_151.2	ZNF23 (directAnnotation).
GPBP1	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
GPBP1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
GPBP1	transfac_pro__M03806	ZBTB7C (directAnnotation).
GPBP1	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
GPBP1	transfac_pro__M02913	SP140 (inferredBy_Orthology).
GPBP1	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
GPBP1	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
GPBP1	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
GPBP1	transfac_pro__M00430	E2F1 (directAnnotation).
GPBP1	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
GPBP1	transfac_pro__M04893	TAF1 (directAnnotation).
GPBP1	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
GPBP1	hdpi__TP73	TP73 (directAnnotation).
GPBP1	transfac_pro__M02865	GMEB1 (inferredBy_Orthology).
GPBP1	hdpi__HIP2	UBE2K (directAnnotation).
GPBP1	taipale_cyt_meth__CREB1_NRTGACGTN_eDBD_repr	CREB1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."