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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: GADD45A

Summary for GADD45A

Gene information	Gene symbol	GADD45A
	Ensembl ID	ENSG00000116717
	Entrez ID	1647
	Gene name	growth arrest and DNA damage inducible alpha
	Synonyms	DDIT1\|GADD45
	Gene type	protein_coding
	UniProtAcc	P24522

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Dataset with differentially expressed gene: GADD45A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	1.3313	0.00e+00
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.269865	1.47e-14
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	-0.433902	3.07e-12
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Plasma cells	0.949821	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Erythrocytes	-0.365224	5.09e-14
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.26268	1.44e-08
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.512577	3.47e-20
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Erythrocytes	0.25015	1.05e-17
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.622316	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.285149	1.48e-30
GSE149214	PC9 cell line	Cell line	Lung cancer	EGFR-mutated non-small cell lung cancer (NSCLC)	Targeted therapy	erlotinib	NA	Malignant cells	0.296621	1.79e-27
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.430219	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.325144	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Erythrocytes	-0.529848	2.77e-11
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	CD4+ T cells	0.333875	1.91e-05
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	CD8+ T cells	0.447304	8.02e-06
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.285876	1.89e-05
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.332115	2.23e-03
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.4303	2.08e-11
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.466766	5.56e-12
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.705453	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Malignant cells	0.419358	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	1.28237	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.80773	8.99e-14
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.460745	5.82e-09
GSE164897_Vem	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib	NA	Malignant cells	0.478741	2.80e-40
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.528144	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.46929	0.00e+00

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Expression of GADD45A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to GADD45A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating GADD45A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
GADD45A	hsa-miR-607	99.2412	NM_001199742
GADD45A	hsa-miR-5582-3p	99.0942	NM_001199742
GADD45A	hsa-miR-659-3p	98.5613	NM_001924
GADD45A	hsa-miR-3163	97.5924	NM_001199742
GADD45A	hsa-miR-148b-3p	95.5796	NM_001924
GADD45A	hsa-miR-152-3p	95.5796	NM_001924
GADD45A	hsa-miR-148a-3p	95.5796	NM_001924
GADD45A	hsa-miR-1226-5p	94.2533	NM_001924
GADD45A	hsa-miR-5002-5p	94.1118	NM_001924
GADD45A	hsa-miR-4270	93.8629	NM_001199742
GADD45A	hsa-miR-302c-5p	93.8349	NM_001924
GADD45A	hsa-miR-4441	93.4286	NM_001199742
GADD45A	hsa-miR-4711-5p	92.2885	NM_001924
GADD45A	hsa-miR-6754-5p	91.8915	NM_001199742
GADD45A	hsa-miR-6841-3p	91.2278	NM_001924
GADD45A	hsa-miR-4678	90.6077	NM_001924
GADD45A	hsa-miR-3613-3p	90.237	NM_001924
GADD45A	hsa-miR-548ar-3p	88.4083	NM_001199742
GADD45A	hsa-miR-374a-5p	88.3917	NM_001199742
GADD45A	hsa-miR-6844	86.5388	NM_001924
GADD45A	hsa-miR-5692a	86.2856	NM_001199742
GADD45A	hsa-miR-580-3p	85.7878	NM_001924
GADD45A	hsa-miR-454-3p	85.3394	NM_001199742
GADD45A	hsa-miR-502-5p	85.0049	NM_001924
GADD45A	hsa-miR-374b-5p	84.8134	NM_001199742
GADD45A	hsa-miR-548bc	84.7088	NM_001199742
GADD45A	hsa-miR-548a-3p	84.7088	NM_001199742
GADD45A	hsa-miR-548e-3p	84.7088	NM_001199742
GADD45A	hsa-miR-548f-3p	84.7088	NM_001199742
GADD45A	hsa-miR-548az-3p	84.7088	NM_001199742
GADD45A	hsa-miR-4276	84.5746	NM_001199742
GADD45A	hsa-miR-3616-3p	82.7472	NM_001924
GADD45A	hsa-miR-130b-3p	81.6104	NM_001199742
GADD45A	hsa-miR-301a-3p	81.6104	NM_001199742
GADD45A	hsa-miR-3666	81.6104	NM_001199742
GADD45A	hsa-miR-4295	81.6104	NM_001199742
GADD45A	hsa-miR-130a-3p	81.6104	NM_001199742
GADD45A	hsa-miR-301b-3p	81.6104	NM_001199742
GADD45A	hsa-miR-1248	80.9461	NM_001924
GADD45A	hsa-miR-6870-3p	80.3218	NM_001924
GADD45A	hsa-miR-6868-3p	80.2298	NM_001199742

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Motifs and transcription factors (TFs) regulating GADD45A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
GADD45A	metacluster_7.13	ZFX (directAnnotation).
GADD45A	cisbp__M01863	ZNF711 (inferredBy_Orthology).
GADD45A	metacluster_151.2	ZNF23 (directAnnotation).
GADD45A	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
GADD45A	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
GADD45A	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
GADD45A	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
GADD45A	kznf__ZNF25_Imbeault2017_OM_MEME	ZNF25 (directAnnotation).
GADD45A	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
GADD45A	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
GADD45A	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
GADD45A	metacluster_3.14	WT1; WT1 (directAnnotation).
GADD45A	cisbp__M07938	E2F1 (directAnnotation).
GADD45A	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
GADD45A	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
GADD45A	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
GADD45A	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
GADD45A	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
GADD45A	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
GADD45A	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
GADD45A	transfac_pro__M01303	SP1 (directAnnotation).
GADD45A	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
GADD45A	swissregulon__hs__CHD1	CHD1 (directAnnotation).
GADD45A	transfac_pro__M02090	E2F4 (directAnnotation).
GADD45A	transfac_pro__M01714	KLF15 (directAnnotation).
GADD45A	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
GADD45A	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
GADD45A	transfac_pro__M02089	E2F3 (directAnnotation).
GADD45A	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
GADD45A	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
GADD45A	transfac_pro__M07436	WT1 (directAnnotation).
GADD45A	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
GADD45A	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
GADD45A	transfac_pro__M02898	SMAD3 (directAnnotation).
GADD45A	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
GADD45A	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
GADD45A	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
GADD45A	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
GADD45A	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
GADD45A	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
GADD45A	transfac_pro__M00652	NRF1 (directAnnotation).
GADD45A	transfac_pro__M04866	HDAC2 (directAnnotation).
GADD45A	jaspar__MA1122.1	TFDP1 (directAnnotation).
GADD45A	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
GADD45A	metacluster_22.11	NFE2 (directAnnotation).
GADD45A	metacluster_22.21	NFE2L2 (inferredBy_Orthology).
GADD45A	metacluster_22.12	NFE2; NFE2L1 (directAnnotation).
GADD45A	metacluster_22.36	BACH2 (directAnnotation).
GADD45A	taipale_tf_pairs__CEBPG_ATF4_NNATGAYGCAAT_CAP	ATF4; CEBPG (directAnnotation).
GADD45A	metacluster_22.17	NFE2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."