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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: DNAJC3

Summary for DNAJC3

Gene information	Gene symbol	DNAJC3
	Ensembl ID	ENSG00000102580
	Entrez ID	5611
	Gene name	DnaJ heat shock protein family (Hsp40) member C3
	Synonyms	ERdj6\|HP58\|P58\|p58(IPK)\|P58IPK\|PRKRI
	Gene type	protein_coding
	UniProtAcc	Q13217

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Dataset with differentially expressed gene: DNAJC3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	0.390109	3.74e-15
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	1.32669	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.725615	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.595428	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.289891	2.57e-35
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.297442	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.338787	3.24e-26

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Expression of DNAJC3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to DNAJC3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating DNAJC3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
DNAJC3	hsa-miR-335-3p	99.404	NM_006260
DNAJC3	hsa-miR-200b-3p	98.5888	NM_006260
DNAJC3	hsa-miR-429	98.5888	NM_006260
DNAJC3	hsa-miR-200c-3p	98.5888	NM_006260
DNAJC3	hsa-miR-607	96.5907	NM_006260
DNAJC3	hsa-miR-4753-3p	94.1458	NM_006260
DNAJC3	hsa-miR-6778-3p	92.834	NM_006260
DNAJC3	hsa-miR-4262	92.814	NM_006260
DNAJC3	hsa-miR-4750-3p	90.484	NM_006260
DNAJC3	hsa-miR-181d-5p	90.2766	NM_006260
DNAJC3	hsa-miR-181a-5p	90.2766	NM_006260
DNAJC3	hsa-miR-181c-5p	90.2766	NM_006260
DNAJC3	hsa-miR-181b-5p	90.2766	NM_006260
DNAJC3	hsa-miR-5688	90.1936	NM_006260
DNAJC3	hsa-miR-495-3p	90.0103	NM_006260
DNAJC3	hsa-miR-2681-5p	88.9749	NM_006260
DNAJC3	hsa-miR-6835-3p	88.7645	NM_006260
DNAJC3	hsa-miR-3671	88.4327	NM_006260
DNAJC3	hsa-miR-3674	88.356	NM_006260
DNAJC3	hsa-miR-302c-5p	88.3155	NM_006260
DNAJC3	hsa-miR-6736-3p	88.2992	NM_006260
DNAJC3	hsa-miR-6895-3p	87.4575	NM_006260
DNAJC3	hsa-miR-29a-5p	87.4501	NM_006260
DNAJC3	hsa-miR-6758-3p	86.3095	NM_006260
DNAJC3	hsa-miR-660-5p	86.2359	NM_006260
DNAJC3	hsa-miR-6507-5p	86.1612	NM_006260
DNAJC3	hsa-miR-9851-3p	85.726	NM_006260
DNAJC3	hsa-miR-602	85.1292	NM_006260
DNAJC3	hsa-miR-3658	84.602	NM_006260
DNAJC3	hsa-miR-5692a	84.384	NM_006260
DNAJC3	hsa-miR-4256	84.0192	NM_006260
DNAJC3	hsa-miR-11181-5p	84.0192	NM_006260
DNAJC3	hsa-miR-9-5p	83.6311	NM_006260
DNAJC3	hsa-miR-593-5p	82.7339	NM_006260
DNAJC3	hsa-miR-6844	82.4893	NM_006260
DNAJC3	hsa-miR-3613-3p	82.3609	NM_006260
DNAJC3	hsa-miR-5591-3p	81.8828	NM_006260
DNAJC3	hsa-miR-4468	81.1096	NM_006260

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Motifs and transcription factors (TFs) regulating DNAJC3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
DNAJC3	transfac_pro__M06213	ZNF267 (directAnnotation).
DNAJC3	transfac_pro__M06035	ZNF749 (directAnnotation).
DNAJC3	kznf__ZNF282_Imbeault2017_OM_RCADE	ZNF282 (directAnnotation).
DNAJC3	metacluster_52.11	ZNF184 (directAnnotation).
DNAJC3	metacluster_98.1	ZNF524 (directAnnotation).
DNAJC3	transfac_pro__M01298	MECP2 (directAnnotation).
DNAJC3	transfac_pro__M04748	GABPA (directAnnotation).
DNAJC3	taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP	ETV4; GCM1 (directAnnotation).
DNAJC3	metacluster_135.11	NR2C2 (directAnnotation).
DNAJC3	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
DNAJC3	tfdimers__MD00038	TFAP2C (directAnnotation).
DNAJC3	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
DNAJC3	metacluster_7.13	ZFX (directAnnotation).
DNAJC3	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
DNAJC3	cisbp__M00968	MTF2 (directAnnotation).
DNAJC3	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
DNAJC3	metacluster_160.20	JUND; PRDM15 (directAnnotation).
DNAJC3	cisbp__M00341	PAX6 (directAnnotation).
DNAJC3	metacluster_198.3	ZFP64 (directAnnotation).
DNAJC3	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
DNAJC3	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
DNAJC3	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
DNAJC3	cisbp__M00788	ZFY (inferredBy_Orthology).
DNAJC3	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
DNAJC3	metacluster_175.1	ZNF283 (directAnnotation).
DNAJC3	hdpi__ZNF304	ZNF304 (directAnnotation).
DNAJC3	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
DNAJC3	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
DNAJC3	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
DNAJC3	transfac_pro__M01199	TRIM28 (directAnnotation).
DNAJC3	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
DNAJC3	metacluster_151.2	ZNF23 (directAnnotation).
DNAJC3	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
DNAJC3	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
DNAJC3	transfac_pro__M03806	ZBTB7C (directAnnotation).
DNAJC3	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
DNAJC3	jaspar__MA0748.2	YY2 (directAnnotation).
DNAJC3	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
DNAJC3	hdpi__HIP2	UBE2K (directAnnotation).
DNAJC3	transfac_pro__M02913	SP140 (inferredBy_Orthology).
DNAJC3	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
DNAJC3	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
DNAJC3	transfac_pro__M02898	SMAD3 (directAnnotation).
DNAJC3	metacluster_191.5	SPDEF (inferredBy_Orthology).
DNAJC3	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
DNAJC3	hdpi__TIMELESS	TIMELESS (directAnnotation).
DNAJC3	transfac_pro__M04893	TAF1 (directAnnotation).
DNAJC3	cisbp__M00249	WT1 (directAnnotation).
DNAJC3	metacluster_182.10	ZFX (directAnnotation).
DNAJC3	transfac_pro__M00430	E2F1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."