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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: DDX3Y

Summary for DDX3Y

Gene information	Gene symbol	DDX3Y
	Ensembl ID	ENSG00000067048
	Entrez ID	8653
	Gene name	DEAD-box helicase 3 Y-linked
	Synonyms	DBY
	Gene type	protein_coding
	UniProtAcc	O15523

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Dataset with differentially expressed gene: DDX3Y

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE197268_Axi-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	axi-cel (CAR-T)	post	CD4+ T cells	-0.275299	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	-0.573126	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.419919	0.00e+00
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	0.268444	4.34e-02
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	B cells	-0.403742	6.00e-05
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.521619	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	CD8+ T cells	-0.411885	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.883523	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.685474	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.329007	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.560402	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.374759	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	NK cells	0.279342	3.85e-02
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.779514	0.00e+00

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Expression of DDX3Y in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to DDX3Y

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating DDX3Y

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
DDX3Y	hsa-miR-4690-5p	93.6408	NM_004660
DDX3Y	hsa-miR-212-5p	93.3102	NM_004660
DDX3Y	hsa-miR-135b-5p	93.2752	NM_004660
DDX3Y	hsa-miR-135a-5p	93.2752	NM_004660
DDX3Y	hsa-miR-548s	92.9607	NM_004660
DDX3Y	hsa-miR-181b-3p	92.7608	NM_004660
DDX3Y	hsa-miR-181b-2-3p	92.7608	NM_004660
DDX3Y	hsa-miR-3187-3p	92.2571	NM_004660
DDX3Y	hsa-miR-19b-3p	91.4737	NM_004660
DDX3Y	hsa-miR-19a-3p	91.4737	NM_004660
DDX3Y	hsa-miR-4420	91.4089	NM_004660
DDX3Y	hsa-miR-4325	90.543	NM_004660
DDX3Y	hsa-miR-6838-5p	89.4088	NM_004660
DDX3Y	hsa-miR-497-5p	89.4088	NM_004660
DDX3Y	hsa-miR-424-5p	89.4088	NM_004660
DDX3Y	hsa-miR-6844	89.058	NM_004660
DDX3Y	hsa-miR-32-3p	88.7282	NM_004660
DDX3Y	hsa-miR-1323	88.6191	NM_004660
DDX3Y	hsa-miR-155-5p	88.0893	NM_004660
DDX3Y	hsa-miR-4464	87.901	NM_004660
DDX3Y	hsa-miR-4748	87.901	NM_004660
DDX3Y	hsa-miR-3135a	87.6923	NM_004660
DDX3Y	hsa-miR-889-3p	87.677	NM_004660
DDX3Y	hsa-miR-5011-5p	87.6002	NM_004660
DDX3Y	hsa-miR-16-5p	87.2728	NM_004660
DDX3Y	hsa-miR-15a-5p	87.2728	NM_004660
DDX3Y	hsa-miR-195-5p	87.2728	NM_004660
DDX3Y	hsa-miR-15b-5p	87.2728	NM_004660
DDX3Y	hsa-miR-588	86.4905	NM_004660
DDX3Y	hsa-miR-4701-5p	86.4905	NM_004660
DDX3Y	hsa-miR-25-3p	86.0508	NM_004660
DDX3Y	hsa-miR-363-3p	86.0508	NM_004660
DDX3Y	hsa-miR-367-3p	86.0508	NM_004660
DDX3Y	hsa-miR-548ay-3p	85.8345	NM_004660
DDX3Y	hsa-miR-548at-3p	85.8345	NM_004660
DDX3Y	hsa-miR-5688	85.0904	NM_004660
DDX3Y	hsa-miR-4704-3p	84.8894	NM_004660
DDX3Y	hsa-miR-6871-5p	84.5196	NM_004660
DDX3Y	hsa-miR-607	84.4804	NM_004660
DDX3Y	hsa-miR-4724-5p	84.4653	NM_004660
DDX3Y	hsa-miR-548o-3p	84.0806	NM_004660
DDX3Y	hsa-miR-3064-5p	83.9482	NM_004660
DDX3Y	hsa-miR-3085-3p	83.9482	NM_004660
DDX3Y	hsa-miR-6504-5p	83.9482	NM_004660
DDX3Y	hsa-miR-32-5p	83.6215	NM_004660
DDX3Y	hsa-miR-92a-3p	83.6215	NM_004660
DDX3Y	hsa-miR-92b-3p	83.6215	NM_004660
DDX3Y	hsa-miR-4262	83.4549	NM_004660
DDX3Y	hsa-miR-3163	82.7698	NM_004660
DDX3Y	hsa-miR-4794	82.7127	NM_004660

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Motifs and transcription factors (TFs) regulating DDX3Y

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
DDX3Y	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
DDX3Y	metacluster_44.20	NKX3-1 (directAnnotation).
DDX3Y	metacluster_44.18	NKX3-2 (directAnnotation).
DDX3Y	transfac_pro__M01969	FOXO1 (directAnnotation).
DDX3Y	metacluster_44.21	NKX3-2 (directAnnotation).
DDX3Y	metacluster_44.13	NKX3-1; NKX3-2 (directAnnotation).
DDX3Y	metacluster_44.19	NKX3-1 (inferredBy_Orthology).
DDX3Y	taipale_cyt_meth__LHX6_MTCGTTAN_FL_meth	LHX6 (directAnnotation).
DDX3Y	hocomoco__PRGR_HUMAN.H11MO.1.A	PGR (directAnnotation).
DDX3Y	transfac_pro__M06529	ZNF596 (directAnnotation).
DDX3Y	metacluster_44.16	NKX3-1 (directAnnotation).
DDX3Y	transfac_pro__M05887	ZNF837 (directAnnotation).
DDX3Y	swissregulon__hs__GMEB2	GMEB2 (directAnnotation).
DDX3Y	swissregulon__mm__Sox5	SOX5 (inferredBy_Orthology).
DDX3Y	metacluster_161.2	LHX8 (directAnnotation).
DDX3Y	transfac_pro__M06563	ZNF483 (directAnnotation).
DDX3Y	hocomoco__GMEB2_HUMAN.H11MO.0.D	GMEB2 (directAnnotation).
DDX3Y	transfac_pro__M06119	ZNF254 (directAnnotation).
DDX3Y	kznf__ZNF777_Imbeault2017_OM_MEME	ZNF777 (directAnnotation).
DDX3Y	metacluster_178.20	ZKSCAN1 (directAnnotation). ZKSCAN1 (inferredBy_Orthology).
DDX3Y	homer__AAGCACTTAA_Nkx3.1	NKX3-1 (directAnnotation).
DDX3Y	transfac_pro__M04844	MAX (directAnnotation).
DDX3Y	transfac_pro__M05976	ZNF223 (directAnnotation).
DDX3Y	taipale_tf_pairs__ETV2_CEBPD_RSCGGANNTTGCGYAAN_CAP_repr	CEBPD; ETV2 (directAnnotation).
DDX3Y	metacluster_65.19	HSF1 (directAnnotation).
DDX3Y	transfac_pro__M02913	SP140 (inferredBy_Orthology).
DDX3Y	hdpi__TP73	TP73 (directAnnotation).
DDX3Y	transfac_pro__M02865	GMEB1 (inferredBy_Orthology).
DDX3Y	transfac_pro__M08894	OVOL1; OVOL2 (directAnnotation).
DDX3Y	metacluster_191.5	SPDEF (inferredBy_Orthology).
DDX3Y	transfac_pro__M01238	DEAF1 (inferredBy_Orthology).
DDX3Y	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
DDX3Y	hdpi__ELF2	ELF2 (directAnnotation).
DDX3Y	metacluster_141.4	GLIS2 (directAnnotation).
DDX3Y	flyfactorsurvey__pho_SOLEXA_F1-3	YY1 (inferredBy_Orthology).
DDX3Y	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
DDX3Y	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
DDX3Y	transfac_pro__M06688	ZKSCAN7 (directAnnotation).
DDX3Y	tfdimers__MD00595	SREBF1; SREBF2; TBP (directAnnotation).
DDX3Y	cisbp__M00839	FOXP1 (directAnnotation).
DDX3Y	transfac_pro__M06750	ZNF510 (directAnnotation).
DDX3Y	tfdimers__MD00297	POU5F1; ZEB1 (directAnnotation).
DDX3Y	metacluster_153.5	SOX13; SOX17; SOX3; SOX30; SOX5; SOX5; SOX5; SOX5; SOX6; SOX8; SOX8; SOX9; SOX9 (directAnnotation). SOX13; SOX14; SOX5; SOX9 (inferredBy_Orthology).
DDX3Y	transfac_pro__M00801	ATF1; ATF2; ATF3; ATF4; ATF7; CREB1; CREM (directAnnotation). ATF7-NPFF (inferredBy_Orthology).
DDX3Y	transfac_pro__M05538	ZNF536 (inferredBy_Orthology).
DDX3Y	metacluster_2.8	IRF4; IRF5; IRF6; IRF9 (directAnnotation). IRF3; IRF5; IRF5; IRF6 (inferredBy_Orthology).
DDX3Y	metacluster_2.9	IRF2; IRF2; IRF2; PRDM1; PRDM1 (directAnnotation). PRDM1 (inferredBy_Orthology).
DDX3Y	jaspar__MA0776.1	MYBL1 (directAnnotation).
DDX3Y	tfdimers__MD00007	E2F1; IRF8 (directAnnotation).
DDX3Y	kznf__ZNF200_Najafabadi2015_ChIP-seq	ZNF200 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."