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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CNN3

Summary for CNN3

Gene information	Gene symbol	CNN3
	Ensembl ID	ENSG00000117519
	Entrez ID	1266
	Gene name	calponin 3
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q15417

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Dataset with differentially expressed gene: CNN3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.0962	6.13e-08
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	-0.3896	0.00e+00
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.47172	0.00e+00
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.833049	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-1.38326	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.409259	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.291616	1.81e-09
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.715475	0.00e+00
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.454497	5.53e-15
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.873572	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.719019	0.00e+00
GSE164897_Vem	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib	NA	Malignant cells	0.339293	0.00e+00

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Expression of CNN3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CNN3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CNN3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CNN3	hsa-miR-7-5p	98.0254	NM_001286055
CNN3	hsa-miR-5007-3p	96.0309	NM_001839
CNN3	hsa-miR-1304-3p	93.9234	NM_001839
CNN3	hsa-miR-1827	93.5354	NM_001839
CNN3	hsa-miR-4766-3p	93.3149	NM_001286055
CNN3	hsa-miR-206	92.2733	NM_001286055
CNN3	hsa-miR-1-3p	92.2733	NM_001286055
CNN3	hsa-miR-613	92.2733	NM_001286055
CNN3	hsa-miR-4715-5p	91.221	NM_001286055
CNN3	hsa-miR-3680-3p	91.178	NM_001839
CNN3	hsa-miR-4728-3p	90.7633	NM_001286055
CNN3	hsa-miR-4718	89.4529	NM_001286055
CNN3	hsa-miR-597-3p	86.8713	NM_001839
CNN3	hsa-miR-153-3p	86.8354	NM_001286055
CNN3	hsa-miR-548an	86.5771	NM_001286055
CNN3	hsa-miR-3613-3p	86.1332	NM_001839
CNN3	hsa-miR-5700	85.6525	NM_001286055
CNN3	hsa-miR-1271-5p	84.9608	NM_001286055
CNN3	hsa-miR-96-5p	84.9608	NM_001286055
CNN3	hsa-miR-12133	84.9608	NM_001286055
CNN3	hsa-miR-513c-3p	83.9605	NM_001839
CNN3	hsa-miR-513a-3p	83.9605	NM_001839
CNN3	hsa-miR-3085-3p	83.8556	NM_001286055
CNN3	hsa-miR-6504-5p	83.8556	NM_001286055
CNN3	hsa-miR-3064-5p	83.8556	NM_001286055
CNN3	hsa-miR-6834-5p	83.8299	NM_001839
CNN3	hsa-miR-27a-3p	82.926	NM_001286055
CNN3	hsa-miR-27b-3p	82.926	NM_001286055
CNN3	hsa-miR-9985	82.926	NM_001286055
CNN3	hsa-miR-548g-3p	82.7459	NM_001839
CNN3	hsa-miR-3606-3p	82.1004	NM_001839
CNN3	hsa-miR-548p	81.9196	NM_001286055
CNN3	hsa-miR-8054	81.5631	NM_001286055
CNN3	hsa-miR-548k	81.5631	NM_001286055
CNN3	hsa-miR-548av-5p	81.5631	NM_001286055
CNN3	hsa-miR-4255	80.469	NM_001839
CNN3	hsa-miR-129-5p	80.1442	NM_001839
CNN3	hsa-miR-9983-3p	80.1442	NM_001839

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Motifs and transcription factors (TFs) regulating CNN3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CNN3	metacluster_7.13	ZFX (directAnnotation).
CNN3	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
CNN3	cisbp__M01863	ZNF711 (inferredBy_Orthology).
CNN3	metacluster_151.2	ZNF23 (directAnnotation).
CNN3	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
CNN3	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
CNN3	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
CNN3	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
CNN3	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
CNN3	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
CNN3	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
CNN3	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
CNN3	swissregulon__hs__ETV6	ETV6 (directAnnotation).
CNN3	transfac_pro__M06564	ZNF578 (directAnnotation).
CNN3	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
CNN3	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
CNN3	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
CNN3	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
CNN3	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
CNN3	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
CNN3	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
CNN3	transfac_pro__M00652	NRF1 (directAnnotation).
CNN3	jaspar__MA1122.1	TFDP1 (directAnnotation).
CNN3	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
CNN3	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
CNN3	transfac_pro__M04617	ZBTB7A (directAnnotation).
CNN3	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
CNN3	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
CNN3	transfac_pro__M07387	ZBTB7A (directAnnotation).
CNN3	transfac_pro__M07436	WT1 (directAnnotation).
CNN3	transfac_pro__M00716	ZBTB14 (directAnnotation).
CNN3	swissregulon__hs__CHD1	CHD1 (directAnnotation).
CNN3	hdpi__HIP2	UBE2K (directAnnotation).
CNN3	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
CNN3	transfac_pro__M04893	TAF1 (directAnnotation).
CNN3	transfac_pro__M03876	ZBTB33 (directAnnotation).
CNN3	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
CNN3	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
CNN3	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
CNN3	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
CNN3	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
CNN3	taipale_tf_pairs__HOXB2_ETV1_ACCGGAAATGA_CAP	ETV1; HOXB2 (directAnnotation).
CNN3	taipale_tf_pairs__ETV2_DLX3_RSCGGAANNNNNNNTAATKR_CAP_repr	DLX3; ETV2 (directAnnotation).
CNN3	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
CNN3	transfac_pro__M06331	ZNF343 (directAnnotation).
CNN3	metacluster_135.11	NR2C2 (directAnnotation).
CNN3	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
CNN3	cisbp__M00968	MTF2 (directAnnotation).
CNN3	metacluster_160.20	JUND; PRDM15 (directAnnotation).
CNN3	cisbp__M00341	PAX6 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."