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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CDKN2C

Summary for CDKN2C

Gene information	Gene symbol	CDKN2C
	Ensembl ID	ENSG00000123080
	Entrez ID	1031
	Gene name	cyclin dependent kinase inhibitor 2C
	Synonyms	INK4C\|p18
	Gene type	protein_coding
	UniProtAcc	P42773

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Dataset with differentially expressed gene: CDKN2C

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-0.87255	7.63e-03
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.521627	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.975446	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.477587	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	-0.332244	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.800671	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	0.330279	0.00e+00

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Expression of CDKN2C in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CDKN2C

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CDKN2C

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CDKN2C	hsa-miR-4804-3p	99.2984	NM_001262
CDKN2C	hsa-miR-4720-3p	98.3912	NM_001262
CDKN2C	hsa-miR-4773	91.1537	NM_001262
CDKN2C	hsa-miR-2052	90.931	NM_001262
CDKN2C	hsa-miR-676-5p	90.0076	NM_001262
CDKN2C	hsa-miR-6074	89.8806	NM_001262
CDKN2C	hsa-miR-892c-5p	89.662	NM_001262
CDKN2C	hsa-miR-4666a-5p	89.5443	NM_001262
CDKN2C	hsa-miR-657	88.9577	NM_001262
CDKN2C	hsa-miR-5000-3p	84.9529	NM_001262

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Motifs and transcription factors (TFs) regulating CDKN2C

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CDKN2C	metacluster_7.13	ZFX (directAnnotation).
CDKN2C	metacluster_151.2	ZNF23 (directAnnotation).
CDKN2C	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
CDKN2C	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
CDKN2C	hdpi__ETV4	ETV4 (directAnnotation).
CDKN2C	transfac_pro__M06071	ZNF814 (directAnnotation).
CDKN2C	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
CDKN2C	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
CDKN2C	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
CDKN2C	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
CDKN2C	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
CDKN2C	transfac_pro__M01175	ZBTB7B (directAnnotation).
CDKN2C	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
CDKN2C	transfac_pro__M01303	SP1 (directAnnotation).
CDKN2C	transfac_pro__M02090	E2F4 (directAnnotation).
CDKN2C	transfac_pro__M02089	E2F3 (directAnnotation).
CDKN2C	metacluster_3.14	WT1; WT1 (directAnnotation).
CDKN2C	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
CDKN2C	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
CDKN2C	cisbp__M07938	E2F1 (directAnnotation).
CDKN2C	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
CDKN2C	transfac_pro__M07436	WT1 (directAnnotation).
CDKN2C	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
CDKN2C	transfac_pro__M02898	SMAD3 (directAnnotation).
CDKN2C	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
CDKN2C	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
CDKN2C	cisbp__M01752	USF2 (inferredBy_Orthology).
CDKN2C	transfac_pro__M06292	ZNF766 (directAnnotation).
CDKN2C	metacluster_141.2	E2F2; E2F3 (directAnnotation).
CDKN2C	kznf__ZFP57_Imbeault2017_OM_MEME	ZFP57 (directAnnotation).
CDKN2C	hdpi__TP73	TP73 (directAnnotation).
CDKN2C	taipale_cyt_meth__ZBTB2_NTTTMCGGTWAN_eDBD	ZBTB2 (directAnnotation).
CDKN2C	metacluster_19.1	GMEB2; GMEB2; GMEB2 (directAnnotation).
CDKN2C	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
CDKN2C	hdpi__HIP2	UBE2K (directAnnotation).
CDKN2C	hdpi__NRL	NRL (directAnnotation).
CDKN2C	transfac_pro__M00430	E2F1 (directAnnotation).
CDKN2C	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
CDKN2C	transfac_pro__M07329	SP7 (directAnnotation).
CDKN2C	metacluster_197.3	E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F5; E2F5; E2F5; E2F5; E2F6; E2F7; E2F7; E2F7; RB1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP2; TFDP2 (directAnnotation).
CDKN2C	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
CDKN2C	transfac_pro__M01837	KLF11 (directAnnotation).
CDKN2C	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
CDKN2C	transfac_pro__M07310	SP5 (directAnnotation).
CDKN2C	transfac_pro__M04817	ZBTB33 (directAnnotation).
CDKN2C	swissregulon__hs__KLF6	KLF6 (directAnnotation).
CDKN2C	transfac_pro__M00716	ZBTB14 (directAnnotation).
CDKN2C	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
CDKN2C	cisbp__M00968	MTF2 (directAnnotation).
CDKN2C	metacluster_163.2	ZNF682 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."