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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CCDC71L

Summary for CCDC71L

Gene information	Gene symbol	CCDC71L
	Ensembl ID	ENSG00000253276
	Entrez ID	168455
	Gene name	coiled-coil domain containing 71 like
	Synonyms	C7orf74\|FLJ36031
	Gene type	protein_coding
	UniProtAcc	Q8N9Z2

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Dataset with differentially expressed gene: CCDC71L

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.364483	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.431853	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.762752	0.00e+00

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Expression of CCDC71L in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CCDC71L

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CCDC71L

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CCDC71L	hsa-miR-4801	98.4437	NM_175884
CCDC71L	hsa-miR-4282	97.854	NM_175884
CCDC71L	hsa-miR-4731-3p	97.5402	NM_175884
CCDC71L	hsa-miR-548aj-3p	97.316	NM_175884
CCDC71L	hsa-miR-548x-3p	97.316	NM_175884
CCDC71L	hsa-miR-548j-3p	97.1029	NM_175884
CCDC71L	hsa-miR-548am-3p	97.1029	NM_175884
CCDC71L	hsa-miR-548ae-3p	97.1029	NM_175884
CCDC71L	hsa-miR-548aq-3p	97.1029	NM_175884
CCDC71L	hsa-miR-548ah-3p	97.1029	NM_175884
CCDC71L	hsa-miR-5011-5p	96.961	NM_175884
CCDC71L	hsa-miR-630	95.6186	NM_175884
CCDC71L	hsa-miR-548d-3p	95.3211	NM_175884
CCDC71L	hsa-miR-4452	94.7772	NM_175884
CCDC71L	hsa-miR-548z	94.4294	NM_175884
CCDC71L	hsa-miR-548ac	94.4294	NM_175884
CCDC71L	hsa-miR-548h-3p	94.4294	NM_175884
CCDC71L	hsa-miR-548bb-3p	94.4294	NM_175884
CCDC71L	hsa-miR-582-5p	93.8529	NM_175884
CCDC71L	hsa-miR-190a-3p	93.7042	NM_175884
CCDC71L	hsa-miR-548c-3p	93.4604	NM_175884
CCDC71L	hsa-miR-10395-3p	92.6208	NM_175884
CCDC71L	hsa-miR-885-5p	92.389	NM_175884
CCDC71L	hsa-miR-607	92.1747	NM_175884
CCDC71L	hsa-miR-153-5p	91.7635	NM_175884
CCDC71L	hsa-miR-3671	91.3178	NM_175884
CCDC71L	hsa-miR-542-3p	91.1685	NM_175884
CCDC71L	hsa-miR-20a-5p	90.9576	NM_175884
CCDC71L	hsa-miR-106b-5p	90.9576	NM_175884
CCDC71L	hsa-miR-4778-5p	90.843	NM_175884
CCDC71L	hsa-miR-520f-5p	90.0867	NM_175884
CCDC71L	hsa-miR-1226-3p	89.9122	NM_175884
CCDC71L	hsa-miR-3613-3p	89.6817	NM_175884
CCDC71L	hsa-miR-106a-5p	89.5619	NM_175884
CCDC71L	hsa-miR-519d-3p	89.5619	NM_175884
CCDC71L	hsa-miR-17-5p	89.5619	NM_175884
CCDC71L	hsa-miR-93-5p	89.5619	NM_175884
CCDC71L	hsa-miR-20b-5p	89.5619	NM_175884
CCDC71L	hsa-miR-526b-3p	89.5619	NM_175884
CCDC71L	hsa-miR-23b-3p	89.448	NM_175884
CCDC71L	hsa-miR-23a-3p	89.448	NM_175884
CCDC71L	hsa-miR-23c	89.448	NM_175884
CCDC71L	hsa-miR-6508-3p	87.7561	NM_175884
CCDC71L	hsa-miR-12123	87.5099	NM_175884
CCDC71L	hsa-miR-4423-3p	86.9024	NM_175884
CCDC71L	hsa-miR-6512-3p	86.5311	NM_175884
CCDC71L	hsa-miR-6720-5p	86.5311	NM_175884
CCDC71L	hsa-miR-548e-5p	86.4364	NM_175884
CCDC71L	hsa-miR-132-3p	86.0058	NM_175884
CCDC71L	hsa-miR-212-3p	86.0058	NM_175884

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Motifs and transcription factors (TFs) regulating CCDC71L

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CCDC71L	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
CCDC71L	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
CCDC71L	hdpi__ETV4	ETV4 (directAnnotation).
CCDC71L	jaspar__MA1122.1	TFDP1 (directAnnotation).
CCDC71L	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
CCDC71L	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
CCDC71L	metacluster_135.11	NR2C2 (directAnnotation).
CCDC71L	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
CCDC71L	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
CCDC71L	metacluster_7.13	ZFX (directAnnotation).
CCDC71L	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
CCDC71L	cisbp__M00968	MTF2 (directAnnotation).
CCDC71L	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
CCDC71L	metacluster_160.20	JUND; PRDM15 (directAnnotation).
CCDC71L	cisbp__M00341	PAX6 (directAnnotation).
CCDC71L	metacluster_198.3	ZFP64 (directAnnotation).
CCDC71L	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
CCDC71L	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
CCDC71L	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
CCDC71L	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
CCDC71L	cisbp__M00788	ZFY (inferredBy_Orthology).
CCDC71L	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
CCDC71L	metacluster_175.1	ZNF283 (directAnnotation).
CCDC71L	hdpi__ZNF304	ZNF304 (directAnnotation).
CCDC71L	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
CCDC71L	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
CCDC71L	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
CCDC71L	transfac_pro__M01199	TRIM28 (directAnnotation).
CCDC71L	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
CCDC71L	metacluster_151.2	ZNF23 (directAnnotation).
CCDC71L	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
CCDC71L	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
CCDC71L	transfac_pro__M03806	ZBTB7C (directAnnotation).
CCDC71L	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
CCDC71L	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
CCDC71L	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
CCDC71L	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
CCDC71L	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
CCDC71L	jaspar__MA1721.1	ZNF93 (directAnnotation).
CCDC71L	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
CCDC71L	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
CCDC71L	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
CCDC71L	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
CCDC71L	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
CCDC71L	transfac_pro__M01253	CNOT3 (directAnnotation).
CCDC71L	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
CCDC71L	transfac_pro__M02913	SP140 (inferredBy_Orthology).
CCDC71L	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
CCDC71L	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
CCDC71L	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."