Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CBX3

Summary for CBX3

Gene information	Gene symbol	CBX3
	Ensembl ID	ENSG00000122565
	Entrez ID	11335
	Gene name	chromobox 3
	Synonyms	HP1Hs-gamma
	Gene type	protein_coding
	UniProtAcc	Q13185

Top

Dataset with differentially expressed gene: CBX3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.452267	0.00e+00
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	0.260191	1.41e-37
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.381412	3.08e-22
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Erythrocytes	-0.493771	1.47e-27
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	B cells	-0.413726	2.49e-02
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.517958	4.33e-21
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Erythrocytes	-0.333977	1.27e-26
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.386704	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-1.24595	0.00e+00
GSE161195	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	DARA-KRD (daratumumab + carfilzomib + lenalidomide + dexamethasone)	post	Malignant cells	0.415554	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.460135	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	B cells	-0.953138	7.77e-05
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.360866	1.28e-37
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.419007	5.46e-31
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.370872	8.69e-31
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.998711	0.00e+00
GSE164897_Vem	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib	NA	Malignant cells	-0.410704	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.285824	0.00e+00

Top

Expression of CBX3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to CBX3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating CBX3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CBX3	hsa-miR-5011-5p	99.9999	NM_007276
CBX3	hsa-miR-190a-3p	99.9984	NM_007276
CBX3	hsa-miR-8485	98.496	NM_007276
CBX3	hsa-miR-3163	96.103	NM_007276
CBX3	hsa-miR-559	94.5548	NM_007276
CBX3	hsa-miR-548aq-5p	94.2315	NM_007276
CBX3	hsa-miR-548as-5p	94.2315	NM_007276
CBX3	hsa-miR-548o-5p	94.2315	NM_007276
CBX3	hsa-miR-548d-5p	94.2315	NM_007276
CBX3	hsa-miR-548am-5p	94.2315	NM_007276
CBX3	hsa-miR-548b-5p	94.2315	NM_007276
CBX3	hsa-miR-548ae-5p	94.2315	NM_007276
CBX3	hsa-miR-548ab	94.2315	NM_007276
CBX3	hsa-miR-548h-5p	94.2315	NM_007276
CBX3	hsa-miR-548au-5p	94.2315	NM_007276
CBX3	hsa-miR-548y	94.2315	NM_007276
CBX3	hsa-miR-548ad-5p	94.2315	NM_007276
CBX3	hsa-miR-548c-5p	94.2315	NM_007276
CBX3	hsa-miR-548ar-5p	94.2315	NM_007276
CBX3	hsa-miR-548ak	94.2315	NM_007276
CBX3	hsa-miR-548a-5p	94.2315	NM_007276
CBX3	hsa-miR-548i	94.2315	NM_007276
CBX3	hsa-miR-548bb-5p	94.2315	NM_007276
CBX3	hsa-miR-548w	94.2315	NM_007276
CBX3	hsa-miR-548ay-5p	94.2315	NM_007276
CBX3	hsa-miR-548j-5p	94.2315	NM_007276
CBX3	hsa-miR-548ap-5p	94.2315	NM_007276
CBX3	hsa-miR-1265	93.0393	NM_007276
CBX3	hsa-miR-1277-5p	92.9821	NM_007276
CBX3	hsa-miR-450b-5p	92.6891	NM_007276
CBX3	hsa-miR-6826-5p	91.3742	NM_007276
CBX3	hsa-miR-3133	91.2393	NM_007276
CBX3	hsa-miR-1185-1-3p	91.1986	NM_007276
CBX3	hsa-let-7f-2-3p	91.1986	NM_007276
CBX3	hsa-miR-1185-2-3p	91.1986	NM_007276
CBX3	hsa-miR-4762-3p	90.1486	NM_007276
CBX3	hsa-miR-449b-5p	89.8624	NM_007276
CBX3	hsa-miR-34c-5p	89.8624	NM_007276
CBX3	hsa-miR-34a-5p	89.8113	NM_007276
CBX3	hsa-miR-449a	89.8113	NM_007276
CBX3	hsa-miR-3613-3p	89.4193	NM_007276
CBX3	hsa-miR-6881-5p	88.5411	NM_007276
CBX3	hsa-miR-410-3p	88.4518	NM_007276
CBX3	hsa-miR-3125	87.0744	NM_007276
CBX3	hsa-miR-3916	87.0744	NM_007276
CBX3	hsa-miR-6859-5p	87.0744	NM_007276
CBX3	hsa-miR-524-5p	86.1584	NM_007276
CBX3	hsa-miR-520d-5p	86.1584	NM_007276
CBX3	hsa-miR-5572	85.1552	NM_007276
CBX3	hsa-miR-22-5p	84.7209	NM_007276

Page: 1 2

Top

Motifs and transcription factors (TFs) regulating CBX3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CBX3	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
CBX3	hdpi__ETV4	ETV4 (directAnnotation).
CBX3	transfac_pro__M04748	GABPA (directAnnotation).
CBX3	hdpi__TP73	TP73 (directAnnotation).
CBX3	cisbp__M02645	ETS1 (directAnnotation).
CBX3	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
CBX3	taipale_tf_pairs__ERF_FOXI1_TGTTKMCGGAWRN_CAP_repr	ERF; FOXI1 (directAnnotation).
CBX3	hdpi__TFAM	TFAM (directAnnotation).
CBX3	metacluster_44.7	NKX3-2 (directAnnotation).
CBX3	transfac_public__M00415	ZEB1 (directAnnotation).
CBX3	transfac_pro__M01175	ZBTB7B (directAnnotation).
CBX3	transfac_pro__M01303	SP1 (directAnnotation).
CBX3	transfac_pro__M07397	ZNF148 (directAnnotation).
CBX3	taipale_tf_pairs__TEAD4_ELK1_RMATWCCGGAWRN_CAP_repr	ELK1; TEAD4 (directAnnotation).
CBX3	hdpi__EBF1	EBF1 (directAnnotation).
CBX3	metacluster_172.6	CHD2; E2F1 (directAnnotation).
CBX3	stark__RCGCMATTW	YY1 (inferredBy_Orthology).
CBX3	swissregulon__hs__GMEB2	GMEB2 (directAnnotation).
CBX3	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_repr	ZNF385D (directAnnotation).
CBX3	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
CBX3	taipale_tf_pairs__FOXO1_ELK1_TGTTGCCGGANNN_CAP	ELK1; FOXO1 (directAnnotation).
CBX3	taipale_tf_pairs__MYBL1_EOMES_RSGTGNNNAACGK_CAP_repr	EOMES; MYBL1 (directAnnotation).
CBX3	transfac_pro__M02913	SP140 (inferredBy_Orthology).
CBX3	transfac_pro__M07483	CXXC1 (directAnnotation).
CBX3	metacluster_141.2	E2F2; E2F3 (directAnnotation).
CBX3	metacluster_111.6	GMEB1; GMEB2 (directAnnotation).
CBX3	taipale_tf_pairs__ETV5_FOXI1_TGTTGNCGGAWRN_CAP	ETV5; FOXI1 (directAnnotation).
CBX3	hdpi__ELF2	ELF2 (directAnnotation).
CBX3	taipale__ELK1_full_NACTTCCGSCGGAARMN_repr	ELK1 (directAnnotation).
CBX3	transfac_pro__M06660	ZNF670 (directAnnotation).
CBX3	transfac_pro__M04844	MAX (directAnnotation).
CBX3	transfac_pro__M06267	ZNF805 (directAnnotation).
CBX3	taipale_tf_pairs__ELK1_FOXI1_WGTTKMCGGAWRTN_CAP	ELK1; FOXI1 (directAnnotation).
CBX3	metacluster_113.3	MYBL1; MYBL1; MYBL2; MYBL2; OVOL1; OVOL2 (directAnnotation). MYB; MYBL1; MYBL1; MYBL1; MYBL1; MYBL2; OVOL1 (inferredBy_Orthology).
CBX3	cisbp__M02928	YY2 (directAnnotation).
CBX3	taipale_tf_pairs__HOXB2_ESRRB_TAATKRNNNNNNAAGGTCA_CAP_repr	ESRRB; HOXB2 (directAnnotation).
CBX3	tfdimers__MD00489	IRF1; NR3C1 (directAnnotation).
CBX3	cisbp__M01816	JUN (inferredBy_Orthology).
CBX3	taipale_tf_pairs__E2F3_DRGX_SGCGCTAATTKN_CAP_repr	DRGX; E2F3 (directAnnotation).
CBX3	transfac_pro__M05966	ZFP14 (directAnnotation).
CBX3	metacluster_26.2	ZNF264 (directAnnotation). NKX2-8 (inferredBy_Orthology).
CBX3	transfac_pro__M04814	RELA (directAnnotation).
CBX3	jaspar__MA1933.1	SREBF2 (directAnnotation).
CBX3	transfac_pro__M04887	TCF12 (directAnnotation).
CBX3	transfac_pro__M06258	ZNF345 (directAnnotation).
CBX3	transfac_pro__M06438	ZNF227 (directAnnotation).
CBX3	transfac_pro__M06405	ZNF329 (directAnnotation).
CBX3	metacluster_161.31	PRRX2 (directAnnotation).
CBX3	taipale_tf_pairs__GCM1_SOX2_RTRSGGGNNNATTGTKY_CAP_repr	GCM1; SOX2 (directAnnotation).
CBX3	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).

Page: 1 2

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."