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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CAV1

Summary for CAV1

Gene information	Gene symbol	CAV1
	Ensembl ID	ENSG00000105974
	Entrez ID	857
	Gene name	caveolin 1
	Synonyms	CAV
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: CAV1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.83785	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	-0.356255	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Malignant cells	-0.389158	5.05e-38
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-3.21938	0.00e+00
GSE149214	PC9 cell line	Cell line	Lung cancer	EGFR-mutated non-small cell lung cancer (NSCLC)	Targeted therapy	erlotinib	NA	Malignant cells	0.503622	2.94e-44
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.4403	7.15e-44
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.607674	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.538525	0.00e+00
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.389265	5.68e-23
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.305281	5.46e-07
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Malignant cells	0.379165	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.327603	1.02e-03
GSE164897_Vem	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib	NA	Malignant cells	1.11771	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	1.38305	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	0.633709	0.00e+00

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Expression of CAV1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CAV1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CAV1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CAV1	hsa-miR-651-3p	99.3146	NM_001172897
CAV1	hsa-miR-4282	99.1722	NM_001172897
CAV1	hsa-miR-1305	98.9047	NM_001172895
CAV1	hsa-miR-12136	98.1931	NM_001172897
CAV1	hsa-miR-605-3p	93.605	NM_001172895
CAV1	hsa-miR-7159-5p	92.0189	NM_001172895
CAV1	hsa-miR-4672	91.3972	NM_001172897
CAV1	hsa-miR-6854-5p	90.7562	NM_001172897
CAV1	hsa-miR-3148	90.4935	NM_001172897
CAV1	hsa-miR-124-3p	89.4581	NM_001172895
CAV1	hsa-miR-506-3p	89.4581	NM_001172895
CAV1	hsa-miR-9718	88.9119	NM_001172895
CAV1	hsa-miR-5002-3p	88.8981	NM_001172897
CAV1	hsa-miR-6839-3p	88.8518	NM_001172897
CAV1	hsa-miR-4733-3p	88.0075	NM_001172895
CAV1	hsa-miR-628-5p	87.5583	NM_001172895
CAV1	hsa-miR-3163	87.4595	NM_001172897
CAV1	hsa-miR-340-5p	86.4081	NM_001172897
CAV1	hsa-miR-577	86.2661	NM_001172895
CAV1	hsa-miR-5189-5p	86.0276	NM_001172897
CAV1	hsa-miR-1271-5p	86.0197	NM_001172895
CAV1	hsa-miR-12133	86.0197	NM_001172895
CAV1	hsa-miR-96-5p	86.0197	NM_001172895
CAV1	hsa-miR-548c-3p	85.8626	NM_001172897
CAV1	hsa-miR-9851-3p	85.3239	NM_001172895
CAV1	hsa-miR-4269	85.2661	NM_001172897
CAV1	hsa-miR-6715b-5p	85.2661	NM_001172897
CAV1	hsa-miR-1207-5p	84.8143	NM_001172897
CAV1	hsa-miR-576-5p	84.3857	NM_001172895
CAV1	hsa-miR-3074-3p	82.8004	NM_001172897
CAV1	hsa-miR-4700-3p	82.6675	NM_001172897
CAV1	hsa-miR-545-3p	82.66	NM_001172895
CAV1	hsa-miR-593-5p	82.5885	NM_001172895
CAV1	hsa-miR-7850-5p	82.386	NM_001172897
CAV1	hsa-miR-30a-3p	82.354	NM_001172897
CAV1	hsa-miR-30e-3p	82.354	NM_001172897
CAV1	hsa-miR-30d-3p	82.354	NM_001172897
CAV1	hsa-miR-6797-3p	81.0464	NM_001172895
CAV1	hsa-miR-4776-5p	80.946	NM_001172895
CAV1	hsa-miR-4773	80.5689	NM_001172895
CAV1	hsa-miR-8062	80.3354	NM_001172895
CAV1	hsa-miR-1285-3p	80.2226	NM_001172897

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Motifs and transcription factors (TFs) regulating CAV1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CAV1	metacluster_151.2	ZNF23 (directAnnotation).
CAV1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
CAV1	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
CAV1	transfac_pro__M07301	NFATC4 (directAnnotation).
CAV1	transfac_pro__M07608	ILF2; NFAT5; NFATC1; NFATC2; NFATC4 (directAnnotation).
CAV1	metacluster_22.21	NFE2L2 (inferredBy_Orthology).
CAV1	taipale_tf_pairs__HOXB13_TBX3_NNNRTAAATCACACNN_CAP_repr	HOXB13; TBX3 (directAnnotation).
CAV1	transfac_pro__M01245	MTERF1 (directAnnotation).
CAV1	taipale_tf_pairs__CEBPG_ATF4_NNATGAYGCAAT_CAP	ATF4; CEBPG (directAnnotation).
CAV1	transfac_pro__M05740	ZNF667 (directAnnotation).
CAV1	transfac_pro__M06614	ZNF594 (directAnnotation).
CAV1	transfac_pro__M03555	ILF2; NFATC2 (directAnnotation).
CAV1	transfac_pro__M06304	ZNF260 (directAnnotation).
CAV1	hdpi__RAB18	RAB18 (directAnnotation).
CAV1	taipale_cyt_meth__JUND_NRTGACGCATN_eDBD_repr	JUND (directAnnotation).
CAV1	metacluster_167.7	IRF8 (inferredBy_Orthology).
CAV1	transfac_pro__M04722	SPI1 (directAnnotation).
CAV1	tfdimers__MD00145	ELF1; ELF2; ELK1; ELK4; ERF; ERG; ETS1; ETS2; ETV7; FLI1; TCF7L2 (directAnnotation).
CAV1	taipale_tf_pairs__ETV2_CEBPD_RSCGGANNTTGCGYAAN_CAP_repr	CEBPD; ETV2 (directAnnotation).
CAV1	jaspar__MA0776.1	MYBL1 (directAnnotation).
CAV1	taipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAP	ELK3; HOXB2 (directAnnotation).
CAV1	metacluster_2.7	IRF1; IRF1; IRF2; IRF2; IRF3; IRF4; IRF5; IRF6; IRF7; IRF7; IRF8; IRF8; IRF9; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; STAT1; STAT1; STAT2 (directAnnotation). PRDM1; PRDM1; PRDM1 (inferredBy_Orthology).
CAV1	transfac_pro__M05860	ZNF548 (directAnnotation).
CAV1	transfac_pro__M04826	EP300 (directAnnotation).
CAV1	transfac_pro__M01298	MECP2 (directAnnotation).
CAV1	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
CAV1	taipale_tf_pairs__TEAD4_ETV4_RCCGGAAATRCC_CAP	ETV4; TEAD4 (directAnnotation).
CAV1	taipale_tf_pairs__ERF_FOXI1_TGTTKMCGGAWRN_CAP_repr	ERF; FOXI1 (directAnnotation).
CAV1	transfac_pro__M00492	STAT1 (directAnnotation).
CAV1	metacluster_174.6	NFYA; NFYB; NFYB; NFYC (directAnnotation).
CAV1	taipale_tf_pairs__GCM1_ELF1_NRCCCRNNCGGAAGNN_CAP_repr	ELF1; GCM1 (directAnnotation).
CAV1	jaspar__MA0502.2	NFYB (directAnnotation).
CAV1	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
CAV1	metacluster_137.2	ATF3; BACH2; BATF; BATF; BATF; BATF; BATF3; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSB; FOSB; FOSB; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; INSM2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; SMARCC1 (directAnnotation). ATF3; ATF3; BATF; FOS; FOSB; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUND; JUND; JUND; JUND (inferredBy_Orthology).
CAV1	metacluster_157.2	ATF3; ATF3; ATF3; BACH1; BACH1; BACH1; BACH2; BACH2; BACH2; BACH2; BATF; BATF; BCL11A; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JDP2; JDP2; JDP2; JDP2; JDP2; JDP2; JDP2; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; JUND; JUND; JUND; JUND; MAF; MAFB; MAFF; MAFG; MAFK; NFE2; NFE2; NFE2; NFE2; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2; NFE2L3; ZNF3; ZSCAN5C (directAnnotation). FOSL1; JUN; JUN; JUN; JUNB; JUNB; JUND (inferredBy_Orthology).
CAV1	metacluster_171.4	TEAD1; TEAD1; TEAD1; TEAD1; TEAD3; TEAD3; TEAD4; TEAD4; TEAD4; TEAD4 (directAnnotation). TEAD1; TEAD2; TEAD4; TEAD4 (inferredBy_Orthology).
CAV1	metacluster_50.1	BATF; BATF; BATF; BATF; BNC2; FOS; FOSB; FOSL1; FOSL1; IRF4; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; SMAD2; SMAD3 (directAnnotation). BATF; BATF; BATF; FOS; FOSL1; FOSL2; JDP2; JUN; JUN; JUND (inferredBy_Orthology).
CAV1	hdpi__TP73	TP73 (directAnnotation).
CAV1	transfac_pro__M06305	ZNF583 (inferredBy_Orthology).
CAV1	taipale_tf_pairs__ETV2_RFX5_NNNTTCCGSNNNNGCAACNN_CAP_repr	ETV2; RFX5 (directAnnotation).
CAV1	metacluster_27.29	ZNF583 (directAnnotation). ZNF583 (inferredBy_Orthology).
CAV1	transfac_pro__M06135	ZNF28 (directAnnotation).
CAV1	metacluster_19.1	GMEB2; GMEB2; GMEB2 (directAnnotation).
CAV1	transfac_pro__M06237	ZNF846 (directAnnotation).
CAV1	transfac_pro__M06766	ZNF835 (directAnnotation).
CAV1	metacluster_29.4	BCL6; BCL6; BCL6; BCL6; BCL6B; BCL6B; BCL6B; BCL6B; BCL6B (directAnnotation). BCL6; BCL6; BCL6 (inferredBy_Orthology).
CAV1	taipale_cyt_meth__HSF5_NRCGTTCTAGAAYGYN_eDBD_repr	HSF5 (directAnnotation).
CAV1	taipale__IRF7_DBD_RAANCGAAAWTCGNTTY_repr	IRF7 (directAnnotation).
CAV1	metacluster_139.7	XBP1 (directAnnotation). XBP1 (inferredBy_Orthology).
CAV1	taipale_cyt_meth__ZNF460_NAACGCCCCCCGN_eDBD_repr	ZNF460 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."