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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: C6orf62

Summary for C6orf62

Gene information	Gene symbol	C6orf62
	Ensembl ID	ENSG00000112308
	Entrez ID	81688
	Gene name	chromosome 6 open reading frame 62
	Synonyms	DKFZP564G182\|FLJ12619\|XTP12
	Gene type	protein_coding
	UniProtAcc	Q9GZU0

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Dataset with differentially expressed gene: C6orf62

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.294934	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.589964	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	0.282674	8.37e-12
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.397853	9.32e-19
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.323671	3.52e-43
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.266649	1.76e-10

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Expression of C6orf62 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to C6orf62

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating C6orf62

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
C6orf62	hsa-miR-3145-5p	98.5657	NM_030939
C6orf62	hsa-miR-5696	97.4513	NM_030939
C6orf62	hsa-miR-544a	97.407	NM_030939
C6orf62	hsa-miR-148b-5p	97.1395	NM_030939
C6orf62	hsa-miR-6874-3p	97.1066	NM_030939
C6orf62	hsa-miR-6502-3p	96.6549	NM_030939
C6orf62	hsa-miR-4766-5p	95.8311	NM_030939
C6orf62	hsa-miR-570-3p	95.7462	NM_030939
C6orf62	hsa-miR-548ap-3p	94.5697	NM_030939
C6orf62	hsa-miR-548aa	94.5697	NM_030939
C6orf62	hsa-miR-548t-3p	94.5697	NM_030939
C6orf62	hsa-miR-3942-3p	94.0173	NM_030939
C6orf62	hsa-miR-23c	93.578	NM_030939
C6orf62	hsa-miR-23a-3p	93.578	NM_030939
C6orf62	hsa-miR-23b-3p	93.578	NM_030939
C6orf62	hsa-miR-4698	93.3955	NM_030939
C6orf62	hsa-miR-3124-3p	92.5625	NM_030939
C6orf62	hsa-miR-3622b-3p	92.3096	NM_030939
C6orf62	hsa-miR-3622a-3p	92.3096	NM_030939
C6orf62	hsa-miR-1184	91.5061	NM_030939
C6orf62	hsa-miR-6844	90.496	NM_030939
C6orf62	hsa-miR-508-5p	89.3943	NM_030939
C6orf62	hsa-miR-4428	89.221	NM_030939
C6orf62	hsa-miR-4796-3p	87.4652	NM_030939
C6orf62	hsa-miR-4708-5p	87.0573	NM_030939
C6orf62	hsa-miR-1299	87.0106	NM_030939
C6orf62	hsa-miR-4714-5p	86.7262	NM_030939
C6orf62	hsa-miR-1912-5p	86.5702	NM_030939
C6orf62	hsa-miR-3148	85.6345	NM_030939
C6orf62	hsa-miR-146a-3p	85.1072	NM_030939
C6orf62	hsa-miR-4255	84.9472	NM_030939
C6orf62	hsa-miR-148a-5p	84.8482	NM_030939
C6orf62	hsa-miR-22-3p	84.8064	NM_030939
C6orf62	hsa-miR-875-3p	84.4652	NM_030939
C6orf62	hsa-miR-1911-5p	83.6894	NM_030939
C6orf62	hsa-miR-6853-3p	83.5406	NM_030939
C6orf62	hsa-miR-218-5p	83.464	NM_030939
C6orf62	hsa-miR-31-3p	82.9021	NM_030939
C6orf62	hsa-miR-367-3p	81.566	NM_030939
C6orf62	hsa-miR-92b-3p	81.566	NM_030939
C6orf62	hsa-miR-92a-3p	81.566	NM_030939
C6orf62	hsa-miR-363-3p	81.566	NM_030939
C6orf62	hsa-miR-32-5p	81.566	NM_030939
C6orf62	hsa-miR-6865-3p	80.1295	NM_030939

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Motifs and transcription factors (TFs) regulating C6orf62

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
C6orf62	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
C6orf62	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
C6orf62	transfac_pro__M05479	ZNF580 (directAnnotation).
C6orf62	hdpi__ETV4	ETV4 (directAnnotation).
C6orf62	transfac_pro__M05628	ZNF735 (directAnnotation).
C6orf62	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
C6orf62	jaspar__MA0079.5	SP1 (directAnnotation).
C6orf62	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
C6orf62	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
C6orf62	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
C6orf62	transfac_pro__M07397	ZNF148 (directAnnotation).
C6orf62	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
C6orf62	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
C6orf62	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
C6orf62	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
C6orf62	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
C6orf62	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
C6orf62	transfac_pro__M01175	ZBTB7B (directAnnotation).
C6orf62	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
C6orf62	tfdimers__MD00151	CHURC1 (directAnnotation).
C6orf62	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
C6orf62	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
C6orf62	transfac_pro__M01303	SP1 (directAnnotation).
C6orf62	swissregulon__hs__CHD1	CHD1 (directAnnotation).
C6orf62	transfac_pro__M02090	E2F4 (directAnnotation).
C6orf62	transfac_pro__M01714	KLF15 (directAnnotation).
C6orf62	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
C6orf62	jaspar__MA1122.1	TFDP1 (directAnnotation).
C6orf62	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
C6orf62	transfac_pro__M02089	E2F3 (directAnnotation).
C6orf62	transfac_pro__M12604	ZNF444 (directAnnotation).
C6orf62	metacluster_3.14	WT1; WT1 (directAnnotation).
C6orf62	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
C6orf62	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
C6orf62	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
C6orf62	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
C6orf62	cisbp__M07938	E2F1 (directAnnotation).
C6orf62	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
C6orf62	transfac_pro__M07436	WT1 (directAnnotation).
C6orf62	transfac_pro__M02281	SP1 (directAnnotation).
C6orf62	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
C6orf62	metacluster_3.3	KLF10; KLF15; KLF16; KLF9; SP1 (directAnnotation).
C6orf62	transfac_pro__M02898	SMAD3 (directAnnotation).
C6orf62	transfac_public__M00491	PATZ1 (directAnnotation).
C6orf62	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
C6orf62	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
C6orf62	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
C6orf62	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
C6orf62	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
C6orf62	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."