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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: BPTF

Summary for BPTF

Gene information	Gene symbol	BPTF
	Ensembl ID	ENSG00000171634
	Entrez ID	2186
	Gene name	bromodomain PHD finger transcription factor
	Synonyms	FAC1\|FALZ\|NURF301
	Gene type	protein_coding
	UniProtAcc	Q12830

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Dataset with differentially expressed gene: BPTF

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.324256	7.54e-10
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.345673	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.342682	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	B cells	-1.09226	1.10e-05
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.266045	1.18e-04
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.560095	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	0.336964	0.00e+00

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Expression of BPTF in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to BPTF

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating BPTF

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
BPTF	hsa-miR-95-5p	99.7833	NM_004459
BPTF	hsa-miR-3064-3p	99.6518	NM_004459
BPTF	hsa-miR-590-3p	98.3865	NM_182641
BPTF	hsa-miR-1468-3p	98.3496	NM_004459
BPTF	hsa-miR-6867-5p	98.2759	NM_182641
BPTF	hsa-miR-450b-5p	97.0303	NM_004459
BPTF	hsa-miR-5689	96.7979	NM_004459
BPTF	hsa-miR-548x-3p	96.1445	NM_004459
BPTF	hsa-miR-548aj-3p	96.1445	NM_004459
BPTF	hsa-miR-190a-3p	96.1125	NM_182641
BPTF	hsa-miR-374c-5p	95.6464	NM_004459
BPTF	hsa-miR-655-3p	95.6464	NM_004459
BPTF	hsa-miR-5683	95.4995	NM_004459
BPTF	hsa-miR-548ac	95.4321	NM_004459
BPTF	hsa-let-7c-3p	95.2966	NM_004459
BPTF	hsa-miR-1290	95.1886	NM_182641
BPTF	hsa-miR-4448	94.9784	NM_004459
BPTF	hsa-miR-379-3p	94.446	NM_182641
BPTF	hsa-miR-411-3p	94.446	NM_182641
BPTF	hsa-miR-376a-3p	93.9502	NM_182641
BPTF	hsa-miR-376b-3p	93.9502	NM_182641
BPTF	hsa-miR-548ah-3p	93.8338	NM_004459
BPTF	hsa-miR-548d-3p	93.8338	NM_004459
BPTF	hsa-miR-548bb-3p	93.8338	NM_004459
BPTF	hsa-miR-548ae-3p	93.8338	NM_004459
BPTF	hsa-miR-548aq-3p	93.8338	NM_004459
BPTF	hsa-miR-548am-3p	93.8338	NM_004459
BPTF	hsa-miR-548z	93.8338	NM_004459
BPTF	hsa-miR-548j-3p	93.8338	NM_004459
BPTF	hsa-miR-548h-3p	93.8338	NM_004459
BPTF	hsa-miR-4727-5p	93.769	NM_004459
BPTF	hsa-miR-6817-5p	93.7342	NM_004459
BPTF	hsa-miR-4769-3p	93.7342	NM_004459
BPTF	hsa-miR-335-3p	93.6	NM_004459
BPTF	hsa-miR-4503	93.3118	NM_004459
BPTF	hsa-miR-605-3p	93.2966	NM_004459
BPTF	hsa-miR-19b-3p	92.9531	NM_004459
BPTF	hsa-miR-19a-3p	92.9531	NM_004459
BPTF	hsa-miR-454-3p	92.031	NM_004459
BPTF	hsa-miR-153-3p	91.5607	NM_004459
BPTF	hsa-miR-6510-5p	90.9462	NM_004459
BPTF	hsa-miR-4295	90.6547	NM_004459
BPTF	hsa-miR-301b-3p	90.6547	NM_004459
BPTF	hsa-miR-3666	90.6547	NM_004459
BPTF	hsa-miR-130b-3p	90.6547	NM_004459
BPTF	hsa-miR-301a-3p	90.6547	NM_004459
BPTF	hsa-miR-130a-3p	90.6547	NM_004459
BPTF	hsa-miR-6886-3p	90.4247	NM_182641
BPTF	hsa-miR-4708-5p	89.9564	NM_004459
BPTF	hsa-miR-3680-3p	89.901	NM_004459

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Motifs and transcription factors (TFs) regulating BPTF

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
BPTF	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
BPTF	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
BPTF	metacluster_3.14	WT1; WT1 (directAnnotation).
BPTF	cisbp__M07938	E2F1 (directAnnotation).
BPTF	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
BPTF	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
BPTF	transfac_pro__M07397	ZNF148 (directAnnotation).
BPTF	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
BPTF	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
BPTF	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
BPTF	transfac_pro__M01175	ZBTB7B (directAnnotation).
BPTF	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
BPTF	tfdimers__MD00151	CHURC1 (directAnnotation).
BPTF	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
BPTF	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
BPTF	transfac_pro__M01303	SP1 (directAnnotation).
BPTF	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
BPTF	swissregulon__hs__CHD1	CHD1 (directAnnotation).
BPTF	transfac_pro__M02090	E2F4 (directAnnotation).
BPTF	transfac_pro__M01714	KLF15 (directAnnotation).
BPTF	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
BPTF	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
BPTF	transfac_pro__M02089	E2F3 (directAnnotation).
BPTF	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
BPTF	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
BPTF	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
BPTF	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
BPTF	transfac_pro__M07436	WT1 (directAnnotation).
BPTF	transfac_pro__M02281	SP1 (directAnnotation).
BPTF	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
BPTF	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
BPTF	transfac_pro__M02898	SMAD3 (directAnnotation).
BPTF	transfac_public__M00491	PATZ1 (directAnnotation).
BPTF	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
BPTF	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
BPTF	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
BPTF	cisbp__M00968	MTF2 (directAnnotation).
BPTF	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
BPTF	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
BPTF	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
BPTF	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
BPTF	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
BPTF	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
BPTF	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
BPTF	jaspar__MA0748.2	YY2 (directAnnotation).
BPTF	jaspar__MA1483.2	ELF2 (directAnnotation).
BPTF	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
BPTF	hdpi__TP73	TP73 (directAnnotation).
BPTF	transfac_pro__M04748	GABPA (directAnnotation).
BPTF	taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP	ELK1; FOXO1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."