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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: BNIP3L

Summary for BNIP3L

Gene information	Gene symbol	BNIP3L
	Ensembl ID	ENSG00000104765
	Entrez ID	665
	Gene name	BCL2 interacting protein 3 like
	Synonyms	BNIP3a\|Nix
	Gene type	protein_coding
	UniProtAcc	O60238

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Dataset with differentially expressed gene: BNIP3L

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.536711	1.06e-04
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.325887	0.00e+00
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	-0.470415	1.23e-21
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	cDCs	0.263917	1.07e-03
GSE197268_Axi-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	axi-cel (CAR-T)	pre	NK cells	-0.450529	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Erythrocytes	0.347751	1.06e-13
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	0.555781	4.83e-14
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.847178	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Erythrocytes	0.607269	2.66e-44
GSE158457	PDX cells	Cell line	Acute lymphoblastic leukemia	T-cell acute lymphoblastic leukemia (ALL)	Targeted therapy	dasatinib	NA	Malignant cells	-0.417502	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	0.958184	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.342869	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.397939	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Erythrocytes	0.363553	1.63e-07
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	0.388318	2.20e-26
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	0.276151	3.50e-07
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.776383	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.327032	0.00e+00
GSE164897_Vem	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib	NA	Malignant cells	0.28865	0.00e+00

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Expression of BNIP3L in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to BNIP3L

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating BNIP3L

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
BNIP3L	hsa-miR-30d-5p	94.1018	NM_004331
BNIP3L	hsa-miR-30e-5p	94.1018	NM_004331
BNIP3L	hsa-miR-30b-5p	94.1018	NM_004331
BNIP3L	hsa-miR-30a-5p	94.1018	NM_004331
BNIP3L	hsa-miR-30c-5p	94.1018	NM_004331
BNIP3L	hsa-miR-5197-5p	92.6752	NM_004331
BNIP3L	hsa-miR-4666a-5p	92.2222	NM_004331
BNIP3L	hsa-miR-548g-3p	91.678	NM_004331
BNIP3L	hsa-miR-6791-3p	91.4186	NM_004331
BNIP3L	hsa-miR-6829-3p	91.4186	NM_004331
BNIP3L	hsa-miR-3658	91.2517	NM_004331
BNIP3L	hsa-miR-3201	90.2822	NM_004331
BNIP3L	hsa-miR-4791	89.7171	NM_004331
BNIP3L	hsa-miR-9718	89.3465	NM_004331
BNIP3L	hsa-miR-24-3p	88.9583	NM_004331
BNIP3L	hsa-miR-545-5p	87.2396	NM_004331
BNIP3L	hsa-miR-183-5p	86.9192	NM_004331
BNIP3L	hsa-miR-133b	86.1087	NM_004331
BNIP3L	hsa-miR-133a-3p	86.1087	NM_004331
BNIP3L	hsa-miR-9-3p	85.5335	NM_004331
BNIP3L	hsa-miR-628-5p	85.4784	NM_004331
BNIP3L	hsa-miR-34b-3p	84.4864	NM_004331
BNIP3L	hsa-miR-4282	84.1316	NM_004331
BNIP3L	hsa-miR-5580-3p	83.1703	NM_004331
BNIP3L	hsa-miR-190a-3p	82.7355	NM_004331
BNIP3L	hsa-miR-1972	82.7118	NM_004331
BNIP3L	hsa-miR-153-5p	82.6169	NM_004331
BNIP3L	hsa-miR-590-3p	82.236	NM_004331
BNIP3L	hsa-miR-4695-5p	82.1738	NM_004331
BNIP3L	hsa-miR-23c	80.7501	NM_004331
BNIP3L	hsa-miR-23a-3p	80.7501	NM_004331
BNIP3L	hsa-miR-23b-3p	80.7501	NM_004331
BNIP3L	hsa-miR-3671	80.2388	NM_004331
BNIP3L	hsa-miR-302e	80.0018	NM_004331

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Motifs and transcription factors (TFs) regulating BNIP3L

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
BNIP3L	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
BNIP3L	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
BNIP3L	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
BNIP3L	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
BNIP3L	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).
BNIP3L	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
BNIP3L	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
BNIP3L	metacluster_3.14	WT1; WT1 (directAnnotation).
BNIP3L	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
BNIP3L	cisbp__M07938	E2F1 (directAnnotation).
BNIP3L	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
BNIP3L	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
BNIP3L	transfac_pro__M07397	ZNF148 (directAnnotation).
BNIP3L	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
BNIP3L	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
BNIP3L	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
BNIP3L	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
BNIP3L	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
BNIP3L	metacluster_7.13	ZFX (directAnnotation).
BNIP3L	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
BNIP3L	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
BNIP3L	transfac_pro__M01175	ZBTB7B (directAnnotation).
BNIP3L	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
BNIP3L	tfdimers__MD00151	CHURC1 (directAnnotation).
BNIP3L	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
BNIP3L	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
BNIP3L	transfac_pro__M01303	SP1 (directAnnotation).
BNIP3L	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
BNIP3L	swissregulon__hs__CHD1	CHD1 (directAnnotation).
BNIP3L	transfac_pro__M02090	E2F4 (directAnnotation).
BNIP3L	transfac_pro__M01714	KLF15 (directAnnotation).
BNIP3L	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
BNIP3L	jaspar__MA1122.1	TFDP1 (directAnnotation).
BNIP3L	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
BNIP3L	transfac_pro__M02089	E2F3 (directAnnotation).
BNIP3L	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
BNIP3L	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
BNIP3L	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
BNIP3L	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
BNIP3L	kznf__ZNF202_Imbeault2017_OM_MEME	ZNF202 (directAnnotation).
BNIP3L	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
BNIP3L	transfac_pro__M07436	WT1 (directAnnotation).
BNIP3L	transfac_pro__M02281	SP1 (directAnnotation).
BNIP3L	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
BNIP3L	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
BNIP3L	metacluster_3.3	KLF10; KLF15; KLF16; KLF9; SP1 (directAnnotation).
BNIP3L	transfac_pro__M02898	SMAD3 (directAnnotation).
BNIP3L	transfac_public__M00491	PATZ1 (directAnnotation).
BNIP3L	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
BNIP3L	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."