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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: ATP1A1

Summary for ATP1A1

Gene information	Gene symbol	ATP1A1
	Ensembl ID	ENSG00000163399
	Entrez ID	476
	Gene name	ATPase Na+/K+ transporting subunit alpha 1
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: ATP1A1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.62487	8.65e-04
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.291123	3.46e-16
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.472001	4.88e-13
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.308122	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	0.252926	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.276488	1.40e-11
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	0.278298	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	CD8+ T cells	0.264875	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.301841	2.20e-15
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.422651	2.65e-14
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.295474	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.254336	8.75e-35
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	0.286492	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	0.30696	4.23e-41
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.356971	2.95e-13
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.384167	7.19e-25
GSE104987	MCF7 cell line	Cell line	Breast cancer	ER+ breast cancer	Targeted therapy	KDM5-C70	NA	Malignant cells	0.708169	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-1.11729	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	1.59087	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.510809	0.00e+00

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Expression of ATP1A1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ATP1A1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ATP1A1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ATP1A1	hsa-miR-124-3p	94.9555	NM_000701
ATP1A1	hsa-miR-506-3p	94.9555	NM_000701
ATP1A1	hsa-miR-488-5p	94.9263	NM_000701
ATP1A1	hsa-miR-6753-5p	92.9252	NM_000701
ATP1A1	hsa-miR-4668-3p	90.6529	NM_000701
ATP1A1	hsa-miR-3163	89.3193	NM_000701
ATP1A1	hsa-miR-5582-5p	87.9784	NM_000701
ATP1A1	hsa-miR-3685	87.7619	NM_000701
ATP1A1	hsa-miR-520d-5p	87.2569	NM_000701
ATP1A1	hsa-miR-524-5p	87.2569	NM_000701
ATP1A1	hsa-miR-5585-5p	85.4345	NM_000701

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Motifs and transcription factors (TFs) regulating ATP1A1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ATP1A1	metacluster_122.17	IRF6 (directAnnotation).
ATP1A1	taipale_tf_pairs__TFAP4_DLX3_NNCAGCTGNNNNNNNTAATTN_HT	DLX3; TFAP4 (directAnnotation).
ATP1A1	tfdimers__MD00456	E2F6; OVOL2 (directAnnotation).
ATP1A1	taipale_tf_pairs__TEAD4_ELK1_RGAATSCGGAAGYN_CAP	ELK1; TEAD4 (directAnnotation).
ATP1A1	kznf__ZNF302_Imbeault2017_RP_RCADE	ZNF302 (directAnnotation).
ATP1A1	taipale_tf_pairs__TEAD4_ELK1_RMATWCCGGAWRN_CAP_repr	ELK1; TEAD4 (directAnnotation).
ATP1A1	kznf__ZNF737_Imbeault2017_OM_MEME	ZNF737 (directAnnotation).
ATP1A1	transfac_public__M00278	GATA1; LDB1; LMO2; TAL1; TCF3 (inferredBy_Orthology).
ATP1A1	metacluster_7.13	ZFX (directAnnotation).
ATP1A1	metacluster_151.2	ZNF23 (directAnnotation).
ATP1A1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
ATP1A1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
ATP1A1	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
ATP1A1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
ATP1A1	hdpi__ETV4	ETV4 (directAnnotation).
ATP1A1	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
ATP1A1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
ATP1A1	jaspar__MA0079.5	SP1 (directAnnotation).
ATP1A1	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
ATP1A1	kznf__ZNF25_Imbeault2017_OM_MEME	ZNF25 (directAnnotation).
ATP1A1	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
ATP1A1	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
ATP1A1	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
ATP1A1	metacluster_3.14	WT1; WT1 (directAnnotation).
ATP1A1	cisbp__M07938	E2F1 (directAnnotation).
ATP1A1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
ATP1A1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ATP1A1	transfac_pro__M07397	ZNF148 (directAnnotation).
ATP1A1	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
ATP1A1	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
ATP1A1	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
ATP1A1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
ATP1A1	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
ATP1A1	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
ATP1A1	transfac_pro__M01175	ZBTB7B (directAnnotation).
ATP1A1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
ATP1A1	tfdimers__MD00151	CHURC1 (directAnnotation).
ATP1A1	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
ATP1A1	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
ATP1A1	transfac_pro__M01303	SP1 (directAnnotation).
ATP1A1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
ATP1A1	transfac_pro__M01714	KLF15 (directAnnotation).
ATP1A1	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
ATP1A1	transfac_pro__M02089	E2F3 (directAnnotation).
ATP1A1	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
ATP1A1	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
ATP1A1	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
ATP1A1	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
ATP1A1	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
ATP1A1	transfac_pro__M07436	WT1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
ATP1A1	"Acetyldigitoxin"	DB00511	small molecule
ATP1A1	"Almitrine"	DB01430	small molecule
ATP1A1	"Aluminium phosphate"	DB14517	small molecule
ATP1A1	"Aluminium"	DB01370	small molecule
ATP1A1	"Aluminum acetate"	DB14518	small molecule
ATP1A1	"Bepridil"	DB01244	small molecule
ATP1A1	"Bretylium"	DB01158	small molecule
ATP1A1	"Ciclopirox"	DB01188	small molecule
ATP1A1	"Deslanoside"	DB01078	small molecule
ATP1A1	"Diazoxide"	DB01119	small molecule
ATP1A1	"Digitoxin"	DB01396	small molecule
ATP1A1	"Digoxin"	DB00390	small molecule
ATP1A1	"Etacrynic acid"	DB00903	small molecule
ATP1A1	"Hydroflumethiazide"	DB00774	small molecule
ATP1A1	"Istaroxime"	DB06157	small molecule
ATP1A1	"Magnesium acetate"	DB13996	small molecule
ATP1A1	"Magnesium cation"	DB01378	small molecule
ATP1A1	"Magnesium lactate"	DB14515	small molecule
ATP1A1	"Magnesium levulinate"	DB14514	small molecule
ATP1A1	"Ouabain"	DB01092	small molecule
ATP1A1	"Potassium acetate"	DB14498	small molecule
ATP1A1	"Potassium cation"	DB01345	small molecule
ATP1A1	"Potassium sulfate"	DB14499	small molecule
ATP1A1	"Potassium"	DB14500	small molecule
ATP1A1	"Trichlormethiazide"	DB01021	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."