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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: ARF4

Summary for ARF4

Gene information	Gene symbol	ARF4
	Ensembl ID	ENSG00000168374
	Entrez ID	378
	Gene name	ADP ribosylation factor 4
	Synonyms	ARF2
	Gene type	protein_coding
	UniProtAcc	P18085

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Dataset with differentially expressed gene: ARF4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	NK cells	0.313818	1.14e-25
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Plasma cells	-0.434817	1.92e-03
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Plasma cells	-0.25178	1.95e-08
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.369261	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	-0.383261	0.00e+00
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.705601	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.291057	1.04e-37
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	0.954613	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Erythrocytes	0.330548	1.10e-13
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.498035	4.69e-27
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.494697	3.27e-17
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.623543	2.34e-35
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.504958	1.23e-18
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.334222	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Malignant cells	-0.416616	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.430781	8.41e-45
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.284272	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	0.576569	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	0.256697	4.20e-20

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Expression of ARF4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ARF4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ARF4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ARF4	hsa-miR-153-5p	98.1678	NM_001660
ARF4	hsa-miR-8077	97.6337	NM_001660
ARF4	hsa-miR-196a-3p	96.5839	NM_001660
ARF4	hsa-miR-93-3p	93.4053	NM_001660
ARF4	hsa-miR-7-5p	92.3495	NM_001660
ARF4	hsa-miR-221-3p	92.0323	NM_001660
ARF4	hsa-miR-222-3p	92.0323	NM_001660
ARF4	hsa-miR-10522-5p	90.7897	NM_001660
ARF4	hsa-miR-3185	90.7897	NM_001660
ARF4	hsa-miR-922	90.6779	NM_001660
ARF4	hsa-miR-182-5p	90.0453	NM_001660
ARF4	hsa-miR-545-5p	89.6162	NM_001660
ARF4	hsa-miR-4673	89.3038	NM_001660
ARF4	hsa-miR-3664-3p	88.5755	NM_001660
ARF4	hsa-miR-373-5p	88.4293	NM_001660
ARF4	hsa-miR-371b-5p	88.4293	NM_001660
ARF4	hsa-miR-616-5p	88.4293	NM_001660
ARF4	hsa-miR-152-3p	88.3015	NM_001660
ARF4	hsa-miR-148b-3p	88.3015	NM_001660
ARF4	hsa-miR-148a-3p	88.3015	NM_001660
ARF4	hsa-miR-4645-5p	88.1244	NM_001660
ARF4	hsa-miR-5583-5p	87.0698	NM_001660
ARF4	hsa-miR-3129-3p	87.0698	NM_001660
ARF4	hsa-miR-4676-3p	86.8228	NM_001660
ARF4	hsa-miR-892c-3p	86.8228	NM_001660
ARF4	hsa-miR-452-5p	86.8228	NM_001660
ARF4	hsa-miR-1250-3p	86.6572	NM_001660
ARF4	hsa-miR-4291	86.2642	NM_001660
ARF4	hsa-miR-6809-5p	85.1964	NM_001660
ARF4	hsa-miR-206	85.0635	NM_001660
ARF4	hsa-miR-1-3p	85.0635	NM_001660
ARF4	hsa-miR-4506	84.5213	NM_001660
ARF4	hsa-miR-548m	83.4933	NM_001660
ARF4	hsa-miR-6731-5p	83.1173	NM_001660
ARF4	hsa-miR-8085	83.1173	NM_001660
ARF4	hsa-miR-3613-3p	82.2523	NM_001660
ARF4	hsa-miR-6071	82.0019	NM_001660
ARF4	hsa-miR-142-3p	82.0018	NM_001660
ARF4	hsa-miR-3619-5p	80.5555	NM_001660

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Motifs and transcription factors (TFs) regulating ARF4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ARF4	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
ARF4	metacluster_151.2	ZNF23 (directAnnotation).
ARF4	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
ARF4	transfac_pro__M05479	ZNF580 (directAnnotation).
ARF4	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
ARF4	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
ARF4	hdpi__ETV4	ETV4 (directAnnotation).
ARF4	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
ARF4	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
ARF4	jaspar__MA0079.5	SP1 (directAnnotation).
ARF4	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
ARF4	hdpi__FLI1	FLI1 (directAnnotation).
ARF4	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
ARF4	metacluster_22.13	MAFK (inferredBy_Orthology).
ARF4	taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP	ETV4; GCM1 (directAnnotation).
ARF4	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
ARF4	transfac_pro__M05605	GATA6 (inferredBy_Orthology).
ARF4	metacluster_22.15	BACH1 (directAnnotation).
ARF4	metacluster_22.14	BACH1 (inferredBy_Orthology).
ARF4	transfac_pro__M04844	MAX (directAnnotation).
ARF4	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
ARF4	swissregulon__hs__CEBPB	CEBPB (directAnnotation).
ARF4	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
ARF4	metacluster_139.7	XBP1 (directAnnotation). XBP1 (inferredBy_Orthology).
ARF4	metacluster_135.11	NR2C2 (directAnnotation).
ARF4	cisbp__M00968	MTF2 (directAnnotation).
ARF4	metacluster_160.20	JUND; PRDM15 (directAnnotation).
ARF4	cisbp__M00341	PAX6 (directAnnotation).
ARF4	metacluster_198.3	ZFP64 (directAnnotation).
ARF4	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
ARF4	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
ARF4	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
ARF4	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
ARF4	metacluster_175.1	ZNF283 (directAnnotation).
ARF4	hdpi__ZNF304	ZNF304 (directAnnotation).
ARF4	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
ARF4	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
ARF4	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
ARF4	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
ARF4	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
ARF4	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ARF4	transfac_pro__M03806	ZBTB7C (directAnnotation).
ARF4	metacluster_50.1	BATF; BATF; BATF; BATF; BNC2; FOS; FOSB; FOSL1; FOSL1; IRF4; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; SMAD2; SMAD3 (directAnnotation). BATF; BATF; BATF; FOS; FOSL1; FOSL2; JDP2; JUN; JUN; JUND (inferredBy_Orthology).
ARF4	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).
ARF4	transfac_pro__M01973	PLAG1 (directAnnotation).
ARF4	metacluster_127.3	FOXO1; FOXO3; FOXO4 (directAnnotation).
ARF4	metacluster_143.13	ZBTB7A (directAnnotation).
ARF4	transfac_pro__M01968	FOXO1 (directAnnotation).
ARF4	hdpi__TIMELESS	TIMELESS (directAnnotation).
ARF4	kznf__ZNF282_Isakova2017_SMiLE-seq	ZNF282 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
ARF4	"Guanosine-5'-Diphosphate"	DB04315	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."