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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ACBD3

Summary for ACBD3

Gene information	Gene symbol	ACBD3
	Ensembl ID	ENSG00000182827
	Entrez ID	64746
	Gene name	acyl-CoA binding domain containing 3
	Synonyms	GCP60\|GOCAP1\|GOLPH1\|PAP7
	Gene type	protein_coding
	UniProtAcc	Q9H3P7

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Dataset with differentially expressed gene: ACBD3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	0.28743	8.26e-25
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.666495	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.400888	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.385656	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.256939	4.81e-39
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.289826	5.95e-18

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Expression of ACBD3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ACBD3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ACBD3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ACBD3	hsa-miR-561-3p	99.143	NM_022735
ACBD3	hsa-miR-548c-3p	97.5951	NM_022735
ACBD3	hsa-miR-196a-1-3p	96.3615	NM_022735
ACBD3	hsa-miR-1277-5p	96.3558	NM_022735
ACBD3	hsa-miR-4668-3p	95.9236	NM_022735
ACBD3	hsa-miR-144-3p	94.9346	NM_022735
ACBD3	hsa-miR-9-3p	94.1338	NM_022735
ACBD3	hsa-miR-548aa	92.4085	NM_022735
ACBD3	hsa-miR-548ap-3p	92.4085	NM_022735
ACBD3	hsa-miR-548t-3p	92.4085	NM_022735
ACBD3	hsa-miR-4671-3p	91.7304	NM_022735
ACBD3	hsa-miR-6830-5p	91.0723	NM_022735
ACBD3	hsa-miR-7977	90.8428	NM_022735
ACBD3	hsa-miR-5187-3p	89.9629	NM_022735
ACBD3	hsa-miR-8062	89.5815	NM_022735
ACBD3	hsa-miR-302c-5p	89.565	NM_022735
ACBD3	hsa-miR-509-3-5p	88.7224	NM_022735
ACBD3	hsa-miR-509-5p	88.7224	NM_022735
ACBD3	hsa-miR-651-3p	88.3804	NM_022735
ACBD3	hsa-miR-3145-3p	88.3762	NM_022735
ACBD3	hsa-miR-12113	88.2348	NM_022735
ACBD3	hsa-miR-4418	86.9049	NM_022735
ACBD3	hsa-miR-4482-3p	86.7881	NM_022735
ACBD3	hsa-miR-449b-5p	86.7116	NM_022735
ACBD3	hsa-miR-34c-5p	86.7116	NM_022735
ACBD3	hsa-miR-6073	86.6181	NM_022735
ACBD3	hsa-miR-4539	86.4985	NM_022735
ACBD3	hsa-miR-587	86.4953	NM_022735
ACBD3	hsa-miR-34a-5p	85.4893	NM_022735
ACBD3	hsa-miR-449a	85.4893	NM_022735
ACBD3	hsa-miR-194-5p	85.4871	NM_022735
ACBD3	hsa-miR-30d-3p	84.9678	NM_022735
ACBD3	hsa-miR-30a-3p	84.9678	NM_022735
ACBD3	hsa-miR-30e-3p	84.9678	NM_022735
ACBD3	hsa-miR-320d	84.8553	NM_022735
ACBD3	hsa-miR-320b	84.8553	NM_022735
ACBD3	hsa-miR-320a-3p	84.8553	NM_022735
ACBD3	hsa-miR-4429	84.8553	NM_022735
ACBD3	hsa-miR-320c	84.8553	NM_022735
ACBD3	hsa-miR-876-5p	84.6623	NM_022735
ACBD3	hsa-miR-548y	84.2262	NM_022735
ACBD3	hsa-miR-186-3p	83.7096	NM_022735
ACBD3	hsa-miR-3167	83.6486	NM_022735
ACBD3	hsa-miR-98-3p	83.5807	NM_022735
ACBD3	hsa-let-7a-3p	83.5807	NM_022735
ACBD3	hsa-let-7b-3p	83.5807	NM_022735
ACBD3	hsa-let-7f-1-3p	83.5807	NM_022735
ACBD3	hsa-miR-6868-5p	83.3039	NM_022735
ACBD3	hsa-miR-559	82.723	NM_022735
ACBD3	hsa-miR-3163	82.6178	NM_022735

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Motifs and transcription factors (TFs) regulating ACBD3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ACBD3	transfac_pro__M07436	WT1 (directAnnotation).
ACBD3	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
ACBD3	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ACBD3	transfac_pro__M01122	ZNF219 (directAnnotation).
ACBD3	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
ACBD3	cisbp__M00249	WT1 (directAnnotation).
ACBD3	transfac_pro__M01303	SP1 (directAnnotation).
ACBD3	transfac_pro__M04595	SALL2 (directAnnotation).
ACBD3	transfac_pro__M07397	ZNF148 (directAnnotation).
ACBD3	metacluster_135.11	NR2C2 (directAnnotation).
ACBD3	metacluster_160.20	JUND; PRDM15 (directAnnotation).
ACBD3	cisbp__M00341	PAX6 (directAnnotation).
ACBD3	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
ACBD3	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
ACBD3	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
ACBD3	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
ACBD3	metacluster_175.1	ZNF283 (directAnnotation).
ACBD3	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
ACBD3	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
ACBD3	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
ACBD3	hdpi__HIP2	UBE2K (directAnnotation).
ACBD3	transfac_pro__M02898	SMAD3 (directAnnotation).
ACBD3	metacluster_191.5	SPDEF (inferredBy_Orthology).
ACBD3	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
ACBD3	hdpi__TIMELESS	TIMELESS (directAnnotation).
ACBD3	transfac_pro__M04893	TAF1 (directAnnotation).
ACBD3	jaspar__MA1721.1	ZNF93 (directAnnotation).
ACBD3	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
ACBD3	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
ACBD3	swissregulon__hs__CHD1	CHD1 (directAnnotation).
ACBD3	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
ACBD3	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
ACBD3	kznf__ZNF311_Imbeault2017_OM_MEME	ZNF311 (directAnnotation).
ACBD3	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
ACBD3	transfac_pro__M12697	ZNF142 (directAnnotation).
ACBD3	tfdimers__MD00364	WT1 (directAnnotation).
ACBD3	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
ACBD3	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
ACBD3	transfac_pro__M01973	PLAG1 (directAnnotation).
ACBD3	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
ACBD3	metacluster_143.13	ZBTB7A (directAnnotation).
ACBD3	hocomoco__XBP1_HUMAN.H11MO.0.D	XBP1 (directAnnotation).
ACBD3	transfac_pro__M07387	ZBTB7A (directAnnotation).
ACBD3	kznf__ZNF548_Imbeault2017_OM_RCADE	ZNF548 (directAnnotation).
ACBD3	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
ACBD3	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
ACBD3	metacluster_196.3	NR1H4; NR2F6; PRDM14; ZNF264; ZNF264 (directAnnotation). HNF4A; HNF4G; NR1D1; NR1D1; NR1D1; NR1D2; NR1D2; NR1D2; NR1H2; NR1H2; NR1H2; NR1H3; NR1H3; NR1H3; NR1I2; NR1I2; NR1I2; NR2C1; NR2C2; NR2F2; NR2F6; PPARA; PPARA; PPARA; PPARD; PPARD; PPARD; PPARG; PPARG; PPARG; RARA; RARA; RARA; RARB; RARB; RARB; RORA; RORA; RORA; RORB; RORB; RORB; RORC; RORC; RORC; RXRA; RXRB; RXRG; THRA; THRA; THRA; VDR; VDR; VDR (inferredBy_Orthology).
ACBD3	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
ACBD3	taipale_tf_pairs__ETV5_TCF3_RNCGGAAGNNNNNCASSTGN_CAP_repr	ETV5; TCF3 (directAnnotation).
ACBD3	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."