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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ABCA5

Summary for ABCA5

Gene information	Gene symbol	ABCA5
	Ensembl ID	ENSG00000154265
	Entrez ID	23461
	Gene name	ATP binding cassette subfamily A member 5
	Synonyms	EST90625
	Gene type	protein_coding
	UniProtAcc	Q8WWZ7

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Dataset with differentially expressed gene: ABCA5

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.40051	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.364229	1.96e-36
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.455582	0.00e+00

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Expression of ABCA5 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ABCA5

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ABCA5

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ABCA5	hsa-miR-656-3p	98.1673	NM_018672
ABCA5	hsa-miR-1277-5p	98.1502	NM_018672
ABCA5	hsa-miR-548c-3p	98.0635	NM_018672
ABCA5	hsa-miR-190a-3p	97.9567	NM_018672
ABCA5	hsa-miR-3163	94.9812	NM_018672
ABCA5	hsa-miR-5692a	94.4005	NM_018672
ABCA5	hsa-miR-466	93.403	NM_018672
ABCA5	hsa-miR-5002-3p	91.7374	NM_018672
ABCA5	hsa-miR-548x-3p	91.4988	NM_018672
ABCA5	hsa-miR-548aj-3p	91.4988	NM_018672
ABCA5	hsa-miR-126-5p	91.0739	NM_018672
ABCA5	hsa-miR-548aq-3p	90.9134	NM_018672
ABCA5	hsa-miR-548j-3p	90.9134	NM_018672
ABCA5	hsa-miR-548am-3p	90.9134	NM_018672
ABCA5	hsa-miR-548ah-3p	90.9134	NM_018672
ABCA5	hsa-miR-548ae-3p	90.9134	NM_018672
ABCA5	hsa-miR-3941	90.3493	NM_018672
ABCA5	hsa-miR-4307	90.0533	NM_018672
ABCA5	hsa-miR-5011-5p	89.0849	NM_018672
ABCA5	hsa-miR-452-3p	88.7209	NM_018672
ABCA5	hsa-miR-4774-3p	86.44	NM_018672
ABCA5	hsa-miR-4282	86.3845	NM_018672
ABCA5	hsa-miR-6885-3p	85.7373	NM_018672
ABCA5	hsa-miR-4310	85.3489	NM_018672
ABCA5	hsa-miR-708-3p	84.3794	NM_018672
ABCA5	hsa-miR-548e-5p	84.067	NM_018672
ABCA5	hsa-miR-4719	83.812	NM_018672
ABCA5	hsa-miR-3119	83.8026	NM_018672
ABCA5	hsa-miR-4795-3p	83.5469	NM_018672
ABCA5	hsa-miR-559	82.7899	NM_018672
ABCA5	hsa-miR-371b-5p	82.6442	NM_018672
ABCA5	hsa-miR-373-5p	82.6442	NM_018672
ABCA5	hsa-miR-616-5p	82.6442	NM_018672
ABCA5	hsa-miR-561-3p	82.4333	NM_018672
ABCA5	hsa-miR-497-3p	82.3287	NM_018672
ABCA5	hsa-miR-4672	81.7175	NM_018672
ABCA5	hsa-miR-627-3p	80.5471	NM_018672
ABCA5	hsa-miR-548aq-5p	80.3902	NM_018672
ABCA5	hsa-miR-548bb-5p	80.3902	NM_018672
ABCA5	hsa-miR-548ap-5p	80.3902	NM_018672
ABCA5	hsa-miR-548j-5p	80.3902	NM_018672
ABCA5	hsa-miR-548y	80.3902	NM_018672
ABCA5	hsa-miR-548c-5p	80.3902	NM_018672
ABCA5	hsa-miR-548ay-5p	80.3902	NM_018672
ABCA5	hsa-miR-548ab	80.3902	NM_018672
ABCA5	hsa-miR-548au-5p	80.3902	NM_018672
ABCA5	hsa-miR-548a-5p	80.3902	NM_018672
ABCA5	hsa-miR-548d-5p	80.3902	NM_018672
ABCA5	hsa-miR-548am-5p	80.3902	NM_018672
ABCA5	hsa-miR-548ae-5p	80.3902	NM_018672

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Motifs and transcription factors (TFs) regulating ABCA5

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ABCA5	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
ABCA5	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
ABCA5	kznf__ZNF25_Imbeault2017_OM_MEME	ZNF25 (directAnnotation).
ABCA5	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
ABCA5	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
ABCA5	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).
ABCA5	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
ABCA5	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
ABCA5	metacluster_3.14	WT1; WT1 (directAnnotation).
ABCA5	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
ABCA5	cisbp__M07938	E2F1 (directAnnotation).
ABCA5	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
ABCA5	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ABCA5	transfac_pro__M07397	ZNF148 (directAnnotation).
ABCA5	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
ABCA5	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
ABCA5	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
ABCA5	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
ABCA5	metacluster_7.13	ZFX (directAnnotation).
ABCA5	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
ABCA5	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
ABCA5	transfac_pro__M01175	ZBTB7B (directAnnotation).
ABCA5	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
ABCA5	tfdimers__MD00151	CHURC1 (directAnnotation).
ABCA5	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
ABCA5	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
ABCA5	transfac_pro__M01303	SP1 (directAnnotation).
ABCA5	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
ABCA5	swissregulon__hs__CHD1	CHD1 (directAnnotation).
ABCA5	transfac_pro__M02090	E2F4 (directAnnotation).
ABCA5	transfac_pro__M01714	KLF15 (directAnnotation).
ABCA5	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
ABCA5	jaspar__MA1122.1	TFDP1 (directAnnotation).
ABCA5	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
ABCA5	transfac_pro__M02089	E2F3 (directAnnotation).
ABCA5	transfac_pro__M12604	ZNF444 (directAnnotation).
ABCA5	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
ABCA5	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
ABCA5	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
ABCA5	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
ABCA5	kznf__ZNF202_Imbeault2017_OM_MEME	ZNF202 (directAnnotation).
ABCA5	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
ABCA5	transfac_pro__M07436	WT1 (directAnnotation).
ABCA5	transfac_pro__M02281	SP1 (directAnnotation).
ABCA5	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
ABCA5	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
ABCA5	metacluster_3.3	KLF10; KLF15; KLF16; KLF9; SP1 (directAnnotation).
ABCA5	transfac_pro__M02898	SMAD3 (directAnnotation).
ABCA5	transfac_public__M00491	PATZ1 (directAnnotation).
ABCA5	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."