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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor
	Acts as a drug target

Gene: RORA

Summary for RORA

Gene information	Gene symbol	RORA
	Ensembl ID	ENSG00000069667
	Entrez ID	6095
	Gene name	RAR related orphan receptor A
	Synonyms	NR1F1\|ROR1\|ROR2\|ROR3\|RZRA
	Gene type	protein_coding
	UniProtAcc	P35398

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Dataset with differentially expressed gene: RORA

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.366482	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.316327	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	CD8+ T cells	-0.273906	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.2653	9.15e-21
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	0.387471	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	CD8+ T cells	0.26685	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	CD8+ T cells	0.554133	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	NK cells	0.35648	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	CD4+ T cells	0.367447	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	CD8+ T cells	0.449601	2.06e-08
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.37251	1.88e-31
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	CD8+ T cells	0.398038	3.65e-05
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	pre	CD4+ T cells	-0.329793	7.48e-05
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	pre	CD8+ T cells	-0.322012	3.58e-05

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Expression of RORA in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RORA

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RORA

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RORA	hsa-miR-6733-5p	81.4383	NM_002943
RORA	hsa-miR-6739-5p	81.4383	NM_002943
RORA	hsa-miR-944	81.1471	NM_002943
RORA	hsa-miR-4801	81.1251	NM_002943
RORA	hsa-miR-195-5p	81.1166	NM_002943
RORA	hsa-miR-16-5p	81.1166	NM_002943
RORA	hsa-miR-15b-5p	81.1166	NM_002943
RORA	hsa-miR-15a-5p	81.1166	NM_002943
RORA	hsa-miR-589-3p	81.0717	NM_002943
RORA	hsa-miR-758-3p	81.0389	NM_002943
RORA	hsa-miR-8074	81.0149	NM_002943
RORA	hsa-miR-4677-5p	81.0098	NM_002943
RORA	hsa-miR-501-3p	80.86	NM_002943
RORA	hsa-miR-502-3p	80.86	NM_002943
RORA	hsa-miR-4717-3p	80.821	NM_002943
RORA	hsa-miR-421	80.789	NM_002943
RORA	hsa-miR-539-5p	80.7078	NM_002943
RORA	hsa-miR-4786-3p	80.6603	NM_002943
RORA	hsa-miR-362-3p	80.5022	NM_002943
RORA	hsa-miR-329-3p	80.5022	NM_002943
RORA	hsa-miR-6083	80.4783	NM_002943
RORA	hsa-miR-5007-3p	80.373	NM_002943
RORA	hsa-miR-6797-5p	80.2913	NM_002943
RORA	hsa-miR-1249-5p	80.2913	NM_002943
RORA	hsa-miR-628-5p	80.2738	NM_002943
RORA	hsa-miR-9718	80.2738	NM_002943
RORA	hsa-miR-8087	80.272	NM_002943
RORA	hsa-miR-6838-5p	80.2713	NM_002943
RORA	hsa-miR-520a-3p	80.2349	NM_002943
RORA	hsa-miR-520b-3p	80.2349	NM_002943
RORA	hsa-miR-302c-3p	80.2349	NM_002943
RORA	hsa-miR-302a-3p	80.2349	NM_002943
RORA	hsa-miR-520d-3p	80.2349	NM_002943
RORA	hsa-miR-372-3p	80.2349	NM_002943
RORA	hsa-miR-520e-3p	80.2349	NM_002943
RORA	hsa-miR-520c-3p	80.2349	NM_002943
RORA	hsa-miR-302b-3p	80.2349	NM_002943
RORA	hsa-miR-302d-3p	80.2349	NM_002943
RORA	hsa-miR-5011-3p	80.2305	NM_002943
RORA	hsa-miR-6128	80.0786	NM_002943

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Motifs and transcription factors (TFs) regulating RORA

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RORA	taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP	ETV4; GCM1 (directAnnotation).
RORA	kznf__ZFP57_Imbeault2017_OM_MEME	ZFP57 (directAnnotation).
RORA	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
RORA	metacluster_144.10	ZNF100 (directAnnotation).
RORA	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
RORA	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
RORA	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
RORA	transfac_pro__M04861	SIX5 (directAnnotation).
RORA	transfac_pro__M04826	EP300 (directAnnotation).
RORA	taipale_tf_pairs__ETV2_SOX15_RSCGGAANNNNNNNYWTTGT_CAP_repr	ETV2; SOX15 (directAnnotation).
RORA	hdpi__FLI1	FLI1 (directAnnotation).
RORA	transfac_pro__M06104	ZNF16 (directAnnotation).
RORA	transfac_pro__M06448	ZNF808 (directAnnotation).
RORA	tfdimers__MD00593	GABPA; PITX3 (directAnnotation).
RORA	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
RORA	swissregulon__hs__GMEB2	GMEB2 (directAnnotation).
RORA	tfdimers__MD00410	HMGA1; HMGA2; KLF4 (directAnnotation).
RORA	taipale_tf_pairs__GCM1_ETV7_NTRNGGGCGGAAGNNNTTCCNNN_CAP_repr	ETV7; GCM1 (directAnnotation).
RORA	taipale_tf_pairs__GCM1_ELF1_NRCCCRNNCGGAAGNN_CAP_repr	ELF1; GCM1 (directAnnotation).
RORA	taipale_tf_pairs__ETV2_TBX21_TMACACMGGAARN_CAP	ETV2; TBX21 (directAnnotation).
RORA	taipale_cyt_meth__NR4A1_NAAAGGTCAN_eDBD_1	NR4A1 (directAnnotation).
RORA	metacluster_72.1	ZNF423; ZNF423 (directAnnotation).
RORA	taipale_tf_pairs__PITX1_EOMES_GGATTANNARGTGTKN_CAP_repr	EOMES; PITX1 (directAnnotation).
RORA	tfdimers__MD00007	E2F1; IRF8 (directAnnotation).
RORA	transfac_pro__M05910	ZNF335 (directAnnotation).
RORA	metacluster_26.10	SOX21; SOX7; SOX8 (directAnnotation).
RORA	tfdimers__MD00158	DBP; ZNF354C (directAnnotation).
RORA	taipale_tf_pairs__HOXD12_ELK3_RSCGGAAGTAATAAAN_CAP	ELK3; HOXD12 (directAnnotation).
RORA	hdpi__ZNF124	ZNF124 (directAnnotation).
RORA	taipale_tf_pairs__TEAD4_HES7_RCATTCCNNNNNCRCGYGYN_CAP_repr	HES7; TEAD4 (directAnnotation).
RORA	metacluster_2.9	IRF2; IRF2; IRF2; PRDM1; PRDM1 (directAnnotation). PRDM1 (inferredBy_Orthology).
RORA	metacluster_167.7	IRF8 (inferredBy_Orthology).
RORA	metacluster_141.4	GLIS2 (directAnnotation).
RORA	metacluster_141.2	E2F2; E2F3 (directAnnotation).
RORA	transfac_pro__M06259	ZNF91 (directAnnotation).
RORA	metacluster_111.6	GMEB1; GMEB2 (directAnnotation).
RORA	transfac_pro__M05597	ZNF174 (directAnnotation).
RORA	taipale_tf_pairs__TEAD4_ELK1_RMATWCCGGAWRN_CAP_repr	ELK1; TEAD4 (directAnnotation).
RORA	transfac_pro__M06241	ZNF345 (directAnnotation).
RORA	transfac_pro__M06073	ZNF749 (directAnnotation).
RORA	taipale__YY2_DBD_NNCCGCCATNW_repr	YY2 (directAnnotation).
RORA	metacluster_156.3	DBP; DBP; DBP; DBP; DBP; DBP; DBP; DBP; HLF; HLF; HLF; HLF; HLF; HLF; HLF; NFIL3; NFIL3; NFIL3; NFIL3; NFIL3; NFIL3; NFIL3; TEF; TEF; TEF; TEF; TEF (directAnnotation). DBP; DBP; DBP; DBP; DBP; HLF; HLF; HLF; HLF; HLF; NFIL3; NFIL3; NFILZ; NFILZ; TEF; TEF; TEF; TEF (inferredBy_Orthology).
RORA	transfac_public__M00040	ATF2 (directAnnotation).
RORA	transfac_pro__M06724	ZNF331 (directAnnotation).
RORA	metacluster_2.8	IRF4; IRF5; IRF6; IRF9 (directAnnotation). IRF3; IRF5; IRF5; IRF6 (inferredBy_Orthology).
RORA	metacluster_22.15	BACH1 (directAnnotation).
RORA	metacluster_22.14	BACH1 (inferredBy_Orthology).
RORA	metacluster_22.18	BACH2 (inferredBy_Orthology).
RORA	metacluster_22.13	MAFK (inferredBy_Orthology).
RORA	metacluster_22.19	NFE2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

TF	motif	Expression	Cell type	Dataset	Timepoint
RORA	metacluster_162.4	down	CD8+ T cells	GSE169246_PacTissue	post

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
RORA	"Cholesterol sulfate"	DB01990	small molecule
RORA	"Cholesterol"	DB04540	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."