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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: INO80D

Summary for INO80D

Gene information	Gene symbol	INO80D
	Ensembl ID	ENSG00000283510
	Entrez ID	54891
	Gene name	INO80 complex subunit D
	Synonyms	FLJ20309
	Gene type	protein_coding
	UniProtAcc	Q53TQ3

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Dataset with differentially expressed gene: INO80D

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.286199	4.60e-37
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.265601	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.287613	1.13e-34

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Expression of INO80D in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to INO80D

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating INO80D

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
INO80D	hsa-miR-509-3-5p	88.4502	NM_017759
INO80D	hsa-miR-200a-3p	88.4325	NM_017759
INO80D	hsa-miR-141-3p	88.4325	NM_017759
INO80D	hsa-miR-11181-3p	88.4143	NM_017759
INO80D	hsa-miR-147b-5p	88.4054	NM_017759
INO80D	hsa-miR-4646-5p	88.3725	NM_017759
INO80D	hsa-miR-4524a-3p	88.1098	NM_017759
INO80D	hsa-miR-144-5p	88.0316	NM_017759
INO80D	hsa-miR-12136	87.8787	NM_017759
INO80D	hsa-miR-561-3p	87.8625	NM_017759
INO80D	hsa-miR-183-3p	87.8531	NM_017759
INO80D	hsa-miR-548aw	87.8496	NM_017759
INO80D	hsa-miR-204-3p	87.7085	NM_017759
INO80D	hsa-miR-3198	87.6566	NM_017759
INO80D	hsa-miR-4309	87.6566	NM_017759
INO80D	hsa-miR-4282	87.6553	NM_017759
INO80D	hsa-miR-670-3p	87.642	NM_017759
INO80D	hsa-miR-6083	87.2981	NM_017759
INO80D	hsa-miR-589-5p	87.296	NM_017759
INO80D	hsa-miR-4328	87.1945	NM_017759
INO80D	hsa-miR-4766-5p	87.151	NM_017759
INO80D	hsa-miR-342-3p	87.0079	NM_017759
INO80D	hsa-miR-6878-5p	86.9869	NM_017759
INO80D	hsa-miR-548an	86.9244	NM_017759
INO80D	hsa-miR-5580-3p	86.8689	NM_017759
INO80D	hsa-miR-4317	86.7671	NM_017759
INO80D	hsa-miR-7854-3p	86.7286	NM_017759
INO80D	hsa-miR-4306	86.6416	NM_017759
INO80D	hsa-miR-545-3p	86.4506	NM_017759
INO80D	hsa-miR-186-5p	86.4163	NM_017759
INO80D	hsa-miR-4482-3p	86.4033	NM_017759
INO80D	hsa-miR-1283	86.3397	NM_017759
INO80D	hsa-miR-5692c	86.318	NM_017759
INO80D	hsa-miR-5692b	86.318	NM_017759
INO80D	hsa-miR-191-5p	86.0476	NM_017759
INO80D	hsa-miR-4719	85.7574	NM_017759
INO80D	hsa-miR-4735-5p	85.7295	NM_017759
INO80D	hsa-miR-374b-3p	85.7024	NM_017759
INO80D	hsa-miR-216a-3p	85.6569	NM_017759
INO80D	hsa-miR-128-3p	85.6569	NM_017759
INO80D	hsa-miR-4778-5p	85.6557	NM_017759
INO80D	hsa-miR-3124-3p	85.563	NM_017759
INO80D	hsa-miR-1236-3p	85.5238	NM_017759
INO80D	hsa-miR-3663-3p	85.5078	NM_017759
INO80D	hsa-miR-193a-3p	85.4385	NM_017759
INO80D	hsa-miR-193b-3p	85.4385	NM_017759
INO80D	hsa-miR-5003-5p	85.3038	NM_017759
INO80D	hsa-miR-10522-5p	85.1195	NM_017759
INO80D	hsa-miR-4770	85.0276	NM_017759
INO80D	hsa-miR-143-3p	85.0276	NM_017759

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Motifs and transcription factors (TFs) regulating INO80D

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
INO80D	transfac_pro__M02913	SP140 (inferredBy_Orthology).
INO80D	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
INO80D	jaspar__MA0748.2	YY2 (directAnnotation).
INO80D	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
INO80D	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
INO80D	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
INO80D	cisbp__M00788	ZFY (inferredBy_Orthology).
INO80D	transfac_pro__M00430	E2F1 (directAnnotation).
INO80D	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
INO80D	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
INO80D	transfac_pro__M04893	TAF1 (directAnnotation).
INO80D	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
INO80D	transfac_pro__M01199	TRIM28 (directAnnotation).
INO80D	metacluster_7.13	ZFX (directAnnotation).
INO80D	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
INO80D	transfac_pro__M02865	GMEB1 (inferredBy_Orthology).
INO80D	transfac_pro__M08894	OVOL1; OVOL2 (directAnnotation).
INO80D	hdpi__HIP2	UBE2K (directAnnotation).
INO80D	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
INO80D	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
INO80D	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
INO80D	metacluster_191.5	SPDEF (inferredBy_Orthology).
INO80D	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
INO80D	transfac_pro__M00938	E2F1 (directAnnotation).
INO80D	transfac_pro__M01238	DEAF1 (inferredBy_Orthology).
INO80D	taipale_cyt_meth__ZBTB37_NYACCGCRNNYACCGYR_eDBD_meth_repr	ZBTB37 (directAnnotation).
INO80D	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
INO80D	hdpi__RARA	RARA (directAnnotation).
INO80D	hdpi__ELF2	ELF2 (directAnnotation).
INO80D	taipale_tf_pairs__TFAP2C_DLX3_NSCCNNNRGGCANNNNNNTAATKR_CAP_repr	DLX3; TFAP2C (directAnnotation).
INO80D	taipale_tf_pairs__ERF_PITX1_NSCGGANNNNNNGGMTTA_CAP	ERF; PITX1 (directAnnotation).
INO80D	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
INO80D	jaspar__MA1583.1	ZFP57 (directAnnotation).
INO80D	cisbp__M00968	MTF2 (directAnnotation).
INO80D	transfac_pro__M02898	SMAD3 (directAnnotation).
INO80D	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
INO80D	hdpi__HTATIP2	HTATIP2 (directAnnotation).
INO80D	jaspar__MA1721.1	ZNF93 (directAnnotation).
INO80D	transfac_pro__M04916	TAF1 (directAnnotation).
INO80D	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
INO80D	jaspar__MA1122.1	TFDP1 (directAnnotation).
INO80D	metacluster_19.6	GMEB1 (directAnnotation). GMEB1 (inferredBy_Orthology).
INO80D	transfac_pro__M07310	SP5 (directAnnotation).
INO80D	cisbp__M01863	ZNF711 (inferredBy_Orthology).
INO80D	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
INO80D	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
INO80D	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
INO80D	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
INO80D	cisbp__M00249	WT1 (directAnnotation).
INO80D	metacluster_182.10	ZFX (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."