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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CREBRF

Summary for CREBRF

Gene information	Gene symbol	CREBRF
	Ensembl ID	ENSG00000164463
	Entrez ID	153222
	Gene name	CREB3 regulatory factor
	Synonyms	C5orf41\|LRF
	Gene type	protein_coding
	UniProtAcc	Q8IUR6

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Dataset with differentially expressed gene: CREBRF

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.82557	6.04e-04
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.320059	1.57e-15
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.465553	1.59e-25
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	0.395352	2.12e-12
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.454847	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.257992	1.55e-18
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.476657	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.254495	4.20e-19
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.604063	8.78e-31

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Expression of CREBRF in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CREBRF

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CREBRF

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CREBRF	hsa-miR-711	84.3502	NM_153607
CREBRF	hsa-miR-659-3p	84.3428	NM_153607
CREBRF	hsa-miR-6822-5p	84.2965	NM_153607
CREBRF	hsa-miR-6750-5p	84.2965	NM_153607
CREBRF	hsa-miR-644a	84.1109	NM_153607
CREBRF	hsa-miR-3185	83.9748	NM_153607
CREBRF	hsa-miR-195-5p	83.7396	NM_153607
CREBRF	hsa-miR-15b-5p	83.7396	NM_153607
CREBRF	hsa-miR-16-5p	83.7396	NM_153607
CREBRF	hsa-miR-15a-5p	83.7396	NM_153607
CREBRF	hsa-miR-675-3p	83.702	NM_153607
CREBRF	hsa-miR-4720-5p	83.4392	NM_153607
CREBRF	hsa-miR-5588-5p	83.4392	NM_153607
CREBRF	hsa-miR-4799-3p	83.4392	NM_153607
CREBRF	hsa-miR-3663-3p	83.436	NM_153607
CREBRF	hsa-miR-4470	83.4261	NM_153607
CREBRF	hsa-miR-12136	82.9698	NM_153607
CREBRF	hsa-miR-199a-3p	82.9129	NM_153607
CREBRF	hsa-miR-3129-5p	82.9129	NM_153607
CREBRF	hsa-miR-199b-3p	82.9129	NM_153607
CREBRF	hsa-miR-152-5p	82.7873	NM_153607
CREBRF	hsa-miR-500b-3p	82.756	NM_153607
CREBRF	hsa-miR-203a-5p	82.6434	NM_153607
CREBRF	hsa-miR-4535	82.5852	NM_153607
CREBRF	hsa-miR-449b-3p	82.558	NM_153607
CREBRF	hsa-miR-193a-3p	82.509	NM_153607
CREBRF	hsa-miR-193b-3p	82.509	NM_153607
CREBRF	hsa-miR-510-3p	82.0029	NM_153607
CREBRF	hsa-miR-548p	81.9115	NM_153607
CREBRF	hsa-miR-3133	81.8642	NM_153607
CREBRF	hsa-miR-4531	81.7926	NM_153607
CREBRF	hsa-miR-6828-5p	81.7842	NM_153607
CREBRF	hsa-miR-670-3p	81.6973	NM_153607
CREBRF	hsa-miR-96-5p	81.5518	NM_153607
CREBRF	hsa-miR-497-5p	81.493	NM_153607
CREBRF	hsa-miR-424-5p	81.493	NM_153607
CREBRF	hsa-miR-6732-3p	81.4891	NM_153607
CREBRF	hsa-miR-10397-5p	81.4521	NM_153607
CREBRF	hsa-miR-624-3p	81.4238	NM_153607
CREBRF	hsa-miR-527	81.2627	NM_153607
CREBRF	hsa-miR-518a-5p	81.2627	NM_153607
CREBRF	hsa-miR-519a-3p	81.2013	NM_153607
CREBRF	hsa-miR-519b-3p	81.2013	NM_153607
CREBRF	hsa-miR-519c-3p	81.2013	NM_153607
CREBRF	hsa-miR-656-3p	80.9568	NM_153607
CREBRF	hsa-miR-4493	80.888	NM_153607
CREBRF	hsa-miR-6079	80.8021	NM_153607
CREBRF	hsa-miR-504-3p	80.759	NM_001168394
CREBRF	hsa-miR-583	80.6871	NM_153607
CREBRF	hsa-miR-9983-3p	80.6409	NM_153607

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Motifs and transcription factors (TFs) regulating CREBRF

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CREBRF	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
CREBRF	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
CREBRF	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
CREBRF	transfac_pro__M04617	ZBTB7A (directAnnotation).
CREBRF	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
CREBRF	kznf__ZNF529_Imbeault2017_RP_ChIP-seq	ZNF529 (directAnnotation).
CREBRF	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
CREBRF	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
CREBRF	transfac_pro__M07387	ZBTB7A (directAnnotation).
CREBRF	transfac_pro__M07436	WT1 (directAnnotation).
CREBRF	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
CREBRF	transfac_pro__M00716	ZBTB14 (directAnnotation).
CREBRF	swissregulon__hs__CHD1	CHD1 (directAnnotation).
CREBRF	hdpi__HIP2	UBE2K (directAnnotation).
CREBRF	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
CREBRF	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
CREBRF	transfac_pro__M04893	TAF1 (directAnnotation).
CREBRF	transfac_pro__M03876	ZBTB33 (directAnnotation).
CREBRF	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
CREBRF	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
CREBRF	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
CREBRF	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
CREBRF	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
CREBRF	metacluster_3.10	KLF2; KLF4 (directAnnotation).
CREBRF	metacluster_163.1	KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF10; KLF10; KLF12; KLF12; KLF12; KLF13; KLF16; KLF17; KLF2; KLF3; KLF3; KLF3; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF5; KLF6; KLF6; KLF6; KLF7; KLF9; KLF9; SALL4; SP1; ZNF148; ZNF148; ZNF526 (directAnnotation). EGR4; KLF1; KLF1; KLF12; KLF12; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF8; KLF9; SP4; SP5; SP5; SP6; SP7; SP8; SP9; ZNF526 (inferredBy_Orthology).
CREBRF	transfac_pro__M01783	SP2 (directAnnotation).
CREBRF	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
CREBRF	cisbp__M00341	PAX6 (directAnnotation).
CREBRF	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
CREBRF	metacluster_111.3	ATF1; ATF3; CREB1; CREB1; CREB1; CREB1; CREB1; CREM; CREM; CREM; CREM; E4F1; E4F1 (directAnnotation). CREB1; CREB1; CREM; JDP2 (inferredBy_Orthology).
CREBRF	transfac_pro__M01253	CNOT3 (directAnnotation).
CREBRF	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
CREBRF	metacluster_7.13	ZFX (directAnnotation).
CREBRF	cisbp__M00968	MTF2 (directAnnotation).
CREBRF	transfac_pro__M04817	ZBTB33 (directAnnotation).
CREBRF	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
CREBRF	transfac_pro__M02089	E2F3 (directAnnotation).
CREBRF	jaspar__MA0748.2	YY2 (directAnnotation).
CREBRF	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
CREBRF	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
CREBRF	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
CREBRF	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
CREBRF	kznf__ZNF846_Imbeault2017_RP_ChIP-seq	ZNF846 (directAnnotation).
CREBRF	transfac_pro__M12686	ZBTB10 (directAnnotation).
CREBRF	kznf__ZNF383_Imbeault2017_RP_RCADE	ZNF383 (directAnnotation).
CREBRF	dbtfbs__ZBTB10_HEK293_ENCSR004PLU_merged_N1	ZBTB10 (directAnnotation).
CREBRF	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
CREBRF	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
CREBRF	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
CREBRF	kznf__ZNF141_Imbeault2017_RP_RCADE	ZNF141 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."