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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: CADM2

Summary for CADM2

Gene information	Gene symbol	CADM2
	Ensembl ID	ENSG00000175161
	Entrez ID	253559
	Gene name	cell adhesion molecule 2
	Synonyms	IGSF4D\|Necl-3\|NECL3\|SynCAM2
	Gene type	protein_coding
	UniProtAcc	Q8N3J6

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Dataset with differentially expressed gene: CADM2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.632592	0.00e+00

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Expression of CADM2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CADM2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CADM2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CADM2	hsa-miR-1252-3p	83.7415	NM_001167674
CADM2	hsa-miR-3133	83.505	NM_001256504
CADM2	hsa-miR-3121-5p	83.3997	NM_001167674
CADM2	hsa-miR-8063	83.3296	NM_001256504
CADM2	hsa-miR-10522-5p	83.3127	NM_001256504
CADM2	hsa-miR-5584-5p	83.2468	NM_001256504
CADM2	hsa-miR-4735-5p	82.9349	NM_001167674
CADM2	hsa-miR-7159-5p	82.717	NM_001256504
CADM2	hsa-miR-8084	82.6449	NM_001256504
CADM2	hsa-miR-1273h-3p	82.4109	NM_001256504
CADM2	hsa-miR-4503	82.0233	NM_001256504
CADM2	hsa-miR-651-5p	81.9308	NM_001167674
CADM2	hsa-miR-138-2-3p	81.7328	NM_001167674
CADM2	hsa-miR-4724-3p	81.6695	NM_001167674
CADM2	hsa-miR-4802-3p	81.4517	NM_001167674
CADM2	hsa-miR-369-3p	81.4321	NM_001256504
CADM2	hsa-miR-106a-3p	81.4128	NM_001167674
CADM2	hsa-miR-512-3p	81.2891	NM_001167674
CADM2	hsa-miR-1264	81.1577	NM_001256504
CADM2	hsa-miR-4803	81.0811	NM_001256504
CADM2	hsa-miR-4328	81.0256	NM_001167674
CADM2	hsa-miR-153-5p	80.8817	NM_001167674
CADM2	hsa-miR-6501-5p	80.861	NM_001167674
CADM2	hsa-miR-6874-5p	80.7179	NM_001167674
CADM2	hsa-miR-450b-5p	80.4285	NM_001256504
CADM2	hsa-miR-6809-3p	80.4117	NM_001256504
CADM2	hsa-miR-142-5p	80.4115	NM_001256504
CADM2	hsa-miR-5590-3p	80.4115	NM_001256504
CADM2	hsa-miR-6831-5p	80.3744	NM_001167674
CADM2	hsa-miR-1238-3p	80.3167	NM_001256504
CADM2	hsa-miR-5007-3p	80.1546	NM_001256504
CADM2	hsa-miR-3166	80.1539	NM_001256504
CADM2	hsa-miR-1193	80.0142	NM_001256504
CADM2	hsa-miR-1276	80.0108	NM_001256504

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Motifs and transcription factors (TFs) regulating CADM2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CADM2	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
CADM2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
CADM2	transfac_pro__M07397	ZNF148 (directAnnotation).
CADM2	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
CADM2	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
CADM2	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
CADM2	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
CADM2	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
CADM2	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
CADM2	transfac_pro__M01175	ZBTB7B (directAnnotation).
CADM2	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
CADM2	tfdimers__MD00151	CHURC1 (directAnnotation).
CADM2	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
CADM2	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
CADM2	transfac_pro__M01303	SP1 (directAnnotation).
CADM2	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
CADM2	swissregulon__hs__CHD1	CHD1 (directAnnotation).
CADM2	transfac_pro__M02090	E2F4 (directAnnotation).
CADM2	transfac_pro__M01714	KLF15 (directAnnotation).
CADM2	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
CADM2	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
CADM2	transfac_pro__M02089	E2F3 (directAnnotation).
CADM2	transfac_pro__M12604	ZNF444 (directAnnotation).
CADM2	metacluster_3.14	WT1; WT1 (directAnnotation).
CADM2	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
CADM2	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
CADM2	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
CADM2	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
CADM2	cisbp__M07938	E2F1 (directAnnotation).
CADM2	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
CADM2	transfac_pro__M07436	WT1 (directAnnotation).
CADM2	transfac_pro__M02281	SP1 (directAnnotation).
CADM2	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
CADM2	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
CADM2	transfac_pro__M02898	SMAD3 (directAnnotation).
CADM2	transfac_public__M00491	PATZ1 (directAnnotation).
CADM2	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."