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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RC3H1

Summary for RC3H1

Gene information	Gene symbol	RC3H1
	Ensembl ID	ENSG00000135870
	Entrez ID	149041
	Gene name	ring finger and CCCH-type domains 1
	Synonyms	KIAA2025\|RNF198\|roquin\|RP5-1198E17.5
	Gene type	protein_coding
	UniProtAcc	Q5TC82

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Dataset with differentially expressed gene: RC3H1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.458907	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.261172	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.34269	2.16e-34

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Expression of RC3H1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RC3H1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RC3H1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RC3H1	hsa-miR-1285-3p	86.9315	NM_001300850
RC3H1	hsa-miR-5003-3p	86.85	NM_001300851
RC3H1	hsa-miR-138-1-3p	86.571	NM_001300851
RC3H1	hsa-miR-548n	86.4178	NM_001300851
RC3H1	hsa-miR-10393-5p	86.3733	NM_001300850
RC3H1	hsa-miR-548p	86.3083	NM_001300851
RC3H1	hsa-miR-3920	86.227	NM_001300851
RC3H1	hsa-miR-320c	86.2081	NM_001300850
RC3H1	hsa-miR-320a-3p	86.2081	NM_001300850
RC3H1	hsa-miR-320d	86.2081	NM_001300850
RC3H1	hsa-miR-4429	86.2081	NM_001300850
RC3H1	hsa-miR-320b	86.2081	NM_001300850
RC3H1	hsa-miR-4495	86.1325	NM_001300850
RC3H1	hsa-miR-4468	86.1179	NM_001300850
RC3H1	hsa-miR-1244	86.0836	NM_001300851
RC3H1	hsa-miR-8066	85.7799	NM_001300851
RC3H1	hsa-miR-4742-5p	85.7346	NM_001300851
RC3H1	hsa-miR-873-3p	85.5444	NM_001300850
RC3H1	hsa-miR-4317	85.5364	NM_001300850
RC3H1	hsa-miR-589-3p	85.5018	NM_001300851
RC3H1	hsa-miR-3924	85.4203	NM_001300851
RC3H1	hsa-miR-545-3p	84.8129	NM_001300850
RC3H1	hsa-miR-513c-3p	84.7755	NM_001300851
RC3H1	hsa-miR-513a-3p	84.7755	NM_001300851
RC3H1	hsa-miR-8076	84.6966	NM_001300851
RC3H1	hsa-miR-3606-3p	84.5921	NM_001300851
RC3H1	hsa-miR-130a-5p	84.4367	NM_001300851
RC3H1	hsa-miR-4772-3p	84.401	NM_001300850
RC3H1	hsa-miR-8057	84.341	NM_001300850
RC3H1	hsa-miR-4715-5p	84.2779	NM_001300851
RC3H1	hsa-miR-4328	83.7359	NM_001300850
RC3H1	hsa-miR-4801	83.2675	NM_001300851
RC3H1	hsa-miR-298	83.2374	NM_001300851
RC3H1	hsa-miR-4762-3p	83.1906	NM_001300851
RC3H1	hsa-miR-5584-5p	83.1478	NM_001300850
RC3H1	hsa-miR-5688	83.1339	NM_001300851
RC3H1	hsa-miR-125b-2-3p	83.1028	NM_001300850
RC3H1	hsa-miR-1825	82.796	NM_001300850
RC3H1	hsa-miR-146a-3p	82.7819	NM_001300851
RC3H1	hsa-miR-380-3p	82.6052	NM_001300850
RC3H1	hsa-miR-3180-5p	82.5411	NM_001300850
RC3H1	hsa-miR-520f-5p	82.5289	NM_001300851
RC3H1	hsa-miR-330-3p	82.0203	NM_001300850
RC3H1	hsa-miR-372-5p	81.8315	NM_001300850
RC3H1	hsa-miR-607	81.7363	NM_001300850
RC3H1	hsa-miR-4499	81.6852	NM_001300850
RC3H1	hsa-miR-302a-5p	81.4378	NM_001300850
RC3H1	hsa-miR-371b-5p	81.2702	NM_001300851
RC3H1	hsa-miR-3678-3p	81.232	NM_001300850
RC3H1	hsa-miR-495-3p	81.0546	NM_001300851

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Motifs and transcription factors (TFs) regulating RC3H1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."